Decrease in vitamin D status in the Greenlandic adult population from 1987-2010.
BACKGROUND:Low vitamin D status may be pronounced in Arctic populations due to limited sun exposure and decreasing intake of traditional food. OBJECTIVE:To investigate serum 25(OH)D3 as a measure of vitamin D status among adult Inuit in Greenland, predictors of low serum 25(OH)D3 concentrations and...
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ftdoajarticles:oai:doaj.org/article:6de5e97655c34b1091a924182cf73d47 2023-05-15T15:14:59+02:00 Decrease in vitamin D status in the Greenlandic adult population from 1987-2010. Nina O Nielsen Marit E Jørgensen Henrik Friis Mads Melbye Bolette Soborg Charlotte Jeppesen Marika Lundqvist Arieh Cohen David M Hougaard Peter Bjerregaard 2014-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0112949 https://doaj.org/article/6de5e97655c34b1091a924182cf73d47 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4252033?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0112949 https://doaj.org/article/6de5e97655c34b1091a924182cf73d47 PLoS ONE, Vol 9, Iss 12, p e112949 (2014) Medicine R Science Q article 2014 ftdoajarticles https://doi.org/10.1371/journal.pone.0112949 2022-12-31T13:29:20Z BACKGROUND:Low vitamin D status may be pronounced in Arctic populations due to limited sun exposure and decreasing intake of traditional food. OBJECTIVE:To investigate serum 25(OH)D3 as a measure of vitamin D status among adult Inuit in Greenland, predictors of low serum 25(OH)D3 concentrations and the trend from 1987 to 2005-2010. DESIGN:A total of 2877 randomly selected Inuit (≥ 18 years) from the Inuit Health in Transition study were included. A sub-sample (n = 330) donated a blood sample in 1987 which allowed assessment of time trends in vitamin D status. RESULTS:The geometric mean serum 25(OH)D3 (25[OH]D2 concentrations were negligible and not reported) in 2005-2010 was lowest among the 18-29 year old individuals (30.7 nmol/L; 95% CI: 29.7; 31.7) and increased with age. In all age-groups it decreased from 1987 to 2005-2010 (32%-58%). Low 25(OH)D3 concentrations (<50 nmol/L) were present in 77% of the 18-29 year old and decreased with age. A characteristic seasonal variation in 25(OH)D3 concentrations was observed (range 33.2-57.1 nmol/L, p<0.001), with the highest concentrations in August to October. Age (2.0% per year increase; CI: 1.7, 2.2), female gender (7.1%; CI: 2.0; 12.5), alcohol intake (0.2% per increase in drinks/week; 0.0; 0.4), and traditional diet (10.0% per 100 g/d increase; CI: 7.9; 12.1) were associated with increased serum 25(OH)D3, whereas smoking (-11.6%; CI: -16.2; -6.9), BMI (-0.6%; CI: -1.1; -0.2) and latitude (-0.7% per degree increase; CI: -1.3; -0.2) were associated with decreased concentrations. CONCLUSION:We identified a remarkable decrease in vitamin D status from 1987 to 2005-2010 and a presently low vitamin D status among Inuit in Greenland. A change away from a traditional diet may well explain the observed decline. The study argues for the need of increased dietary intake of vitamin D and supplementation might be considered. Article in Journal/Newspaper Arctic Greenland greenlandic inuit Directory of Open Access Journals: DOAJ Articles Arctic Greenland PLoS ONE 9 12 e112949 |
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ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Nina O Nielsen Marit E Jørgensen Henrik Friis Mads Melbye Bolette Soborg Charlotte Jeppesen Marika Lundqvist Arieh Cohen David M Hougaard Peter Bjerregaard Decrease in vitamin D status in the Greenlandic adult population from 1987-2010. |
topic_facet |
Medicine R Science Q |
description |
BACKGROUND:Low vitamin D status may be pronounced in Arctic populations due to limited sun exposure and decreasing intake of traditional food. OBJECTIVE:To investigate serum 25(OH)D3 as a measure of vitamin D status among adult Inuit in Greenland, predictors of low serum 25(OH)D3 concentrations and the trend from 1987 to 2005-2010. DESIGN:A total of 2877 randomly selected Inuit (≥ 18 years) from the Inuit Health in Transition study were included. A sub-sample (n = 330) donated a blood sample in 1987 which allowed assessment of time trends in vitamin D status. RESULTS:The geometric mean serum 25(OH)D3 (25[OH]D2 concentrations were negligible and not reported) in 2005-2010 was lowest among the 18-29 year old individuals (30.7 nmol/L; 95% CI: 29.7; 31.7) and increased with age. In all age-groups it decreased from 1987 to 2005-2010 (32%-58%). Low 25(OH)D3 concentrations (<50 nmol/L) were present in 77% of the 18-29 year old and decreased with age. A characteristic seasonal variation in 25(OH)D3 concentrations was observed (range 33.2-57.1 nmol/L, p<0.001), with the highest concentrations in August to October. Age (2.0% per year increase; CI: 1.7, 2.2), female gender (7.1%; CI: 2.0; 12.5), alcohol intake (0.2% per increase in drinks/week; 0.0; 0.4), and traditional diet (10.0% per 100 g/d increase; CI: 7.9; 12.1) were associated with increased serum 25(OH)D3, whereas smoking (-11.6%; CI: -16.2; -6.9), BMI (-0.6%; CI: -1.1; -0.2) and latitude (-0.7% per degree increase; CI: -1.3; -0.2) were associated with decreased concentrations. CONCLUSION:We identified a remarkable decrease in vitamin D status from 1987 to 2005-2010 and a presently low vitamin D status among Inuit in Greenland. A change away from a traditional diet may well explain the observed decline. The study argues for the need of increased dietary intake of vitamin D and supplementation might be considered. |
format |
Article in Journal/Newspaper |
author |
Nina O Nielsen Marit E Jørgensen Henrik Friis Mads Melbye Bolette Soborg Charlotte Jeppesen Marika Lundqvist Arieh Cohen David M Hougaard Peter Bjerregaard |
author_facet |
Nina O Nielsen Marit E Jørgensen Henrik Friis Mads Melbye Bolette Soborg Charlotte Jeppesen Marika Lundqvist Arieh Cohen David M Hougaard Peter Bjerregaard |
author_sort |
Nina O Nielsen |
title |
Decrease in vitamin D status in the Greenlandic adult population from 1987-2010. |
title_short |
Decrease in vitamin D status in the Greenlandic adult population from 1987-2010. |
title_full |
Decrease in vitamin D status in the Greenlandic adult population from 1987-2010. |
title_fullStr |
Decrease in vitamin D status in the Greenlandic adult population from 1987-2010. |
title_full_unstemmed |
Decrease in vitamin D status in the Greenlandic adult population from 1987-2010. |
title_sort |
decrease in vitamin d status in the greenlandic adult population from 1987-2010. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pone.0112949 https://doaj.org/article/6de5e97655c34b1091a924182cf73d47 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Greenland greenlandic inuit |
genre_facet |
Arctic Greenland greenlandic inuit |
op_source |
PLoS ONE, Vol 9, Iss 12, p e112949 (2014) |
op_relation |
http://europepmc.org/articles/PMC4252033?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0112949 https://doaj.org/article/6de5e97655c34b1091a924182cf73d47 |
op_doi |
https://doi.org/10.1371/journal.pone.0112949 |
container_title |
PLoS ONE |
container_volume |
9 |
container_issue |
12 |
container_start_page |
e112949 |
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