Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study
Although obesity in the domestic dog (Canis lupus familiaris) is known to decrease well-being and shorten lifespan, the genetic risk variants associated with canine obesity remain largely unknown. In our study, which focused on the obesity-prone Labrador Retriever breed, we conducted a genome-wide a...
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ftdoajarticles:oai:doaj.org/article:6dbdc30d8906449c9ac1a2ec2a0a9739 2023-10-09T21:50:36+02:00 Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study Michal Antkowiak Maciej Szydlowski 2023-09-01T00:00:00Z https://doi.org/10.3389/fgene.2023.1235821 https://doaj.org/article/6dbdc30d8906449c9ac1a2ec2a0a9739 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fgene.2023.1235821/full https://doaj.org/toc/1664-8021 1664-8021 doi:10.3389/fgene.2023.1235821 https://doaj.org/article/6dbdc30d8906449c9ac1a2ec2a0a9739 Frontiers in Genetics, Vol 14 (2023) labrador retriever obesity ALPL KCTD8 SGSM1 SLC12A6 Genetics QH426-470 article 2023 ftdoajarticles https://doi.org/10.3389/fgene.2023.1235821 2023-09-24T00:37:23Z Although obesity in the domestic dog (Canis lupus familiaris) is known to decrease well-being and shorten lifespan, the genetic risk variants associated with canine obesity remain largely unknown. In our study, which focused on the obesity-prone Labrador Retriever breed, we conducted a genome-wide analysis to identify structural variants linked to body weight and obesity. Obesity status was based on a 5-point body condition score (BCS) and the obese dog group included all dogs with a BCS of 5, along with dogs with the highest body weight within the BCS 4 group. Data from whole-gene sequencing of fifty dogs, including 28 obese dogs, were bioinformatically analyzed to identify potential structural variants that varied in frequency between obese and healthy dogs. The seven most promising variants were further analyzed by droplet digital PCR in a group of 110 dogs, including 63 obese. Our statistical evidence suggests that common structural mutations in or near six genes, specifically ALPL, KCTD8, SGSM1, SLC12A6, RYR3, and VPS26C, may contribute to the variability observed in body weight and body condition scores among Labrador Retriever dogs. These findings emphasize the need for additional research to validate the associations and explore the specific functions of these genes in relation to canine obesity. Article in Journal/Newspaper Canis lupus Directory of Open Access Journals: DOAJ Articles Frontiers in Genetics 14 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
labrador retriever obesity ALPL KCTD8 SGSM1 SLC12A6 Genetics QH426-470 |
spellingShingle |
labrador retriever obesity ALPL KCTD8 SGSM1 SLC12A6 Genetics QH426-470 Michal Antkowiak Maciej Szydlowski Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study |
topic_facet |
labrador retriever obesity ALPL KCTD8 SGSM1 SLC12A6 Genetics QH426-470 |
description |
Although obesity in the domestic dog (Canis lupus familiaris) is known to decrease well-being and shorten lifespan, the genetic risk variants associated with canine obesity remain largely unknown. In our study, which focused on the obesity-prone Labrador Retriever breed, we conducted a genome-wide analysis to identify structural variants linked to body weight and obesity. Obesity status was based on a 5-point body condition score (BCS) and the obese dog group included all dogs with a BCS of 5, along with dogs with the highest body weight within the BCS 4 group. Data from whole-gene sequencing of fifty dogs, including 28 obese dogs, were bioinformatically analyzed to identify potential structural variants that varied in frequency between obese and healthy dogs. The seven most promising variants were further analyzed by droplet digital PCR in a group of 110 dogs, including 63 obese. Our statistical evidence suggests that common structural mutations in or near six genes, specifically ALPL, KCTD8, SGSM1, SLC12A6, RYR3, and VPS26C, may contribute to the variability observed in body weight and body condition scores among Labrador Retriever dogs. These findings emphasize the need for additional research to validate the associations and explore the specific functions of these genes in relation to canine obesity. |
format |
Article in Journal/Newspaper |
author |
Michal Antkowiak Maciej Szydlowski |
author_facet |
Michal Antkowiak Maciej Szydlowski |
author_sort |
Michal Antkowiak |
title |
Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study |
title_short |
Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study |
title_full |
Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study |
title_fullStr |
Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study |
title_full_unstemmed |
Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study |
title_sort |
uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study |
publisher |
Frontiers Media S.A. |
publishDate |
2023 |
url |
https://doi.org/10.3389/fgene.2023.1235821 https://doaj.org/article/6dbdc30d8906449c9ac1a2ec2a0a9739 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Frontiers in Genetics, Vol 14 (2023) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fgene.2023.1235821/full https://doaj.org/toc/1664-8021 1664-8021 doi:10.3389/fgene.2023.1235821 https://doaj.org/article/6dbdc30d8906449c9ac1a2ec2a0a9739 |
op_doi |
https://doi.org/10.3389/fgene.2023.1235821 |
container_title |
Frontiers in Genetics |
container_volume |
14 |
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1779313664965214208 |