Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995)
In order to investigate epidemiological aspects of hepatocellular carcinoma (HCC) in Brazil, basic informations about cases diagnosed from January 1992 to December 1994 were requested to several medical centers of different Brazilian States. A simple questionnaire included age, sex, alcohol abuse (o...
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ftdoajarticles:oai:doaj.org/article:6da23d789ee14f3eb7bbf5f706295b58 2024-09-09T19:28:31+00:00 Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995) GONÇALVES Carlos S. PEREIRA Fausto E. L. Gayotto Luis C.C. 1997-01-01T00:00:00Z https://doaj.org/article/6da23d789ee14f3eb7bbf5f706295b58 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000300008 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/6da23d789ee14f3eb7bbf5f706295b58 Revista do Instituto de Medicina Tropical de São Paulo, Vol 39, Iss 3, Pp 165-170 (1997) Hepatocellular carcinoma Liver Tumors Liver Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1997 ftdoajarticles 2024-08-05T17:49:31Z In order to investigate epidemiological aspects of hepatocellular carcinoma (HCC) in Brazil, basic informations about cases diagnosed from January 1992 to December 1994 were requested to several medical centers of different Brazilian States. A simple questionnaire included age, sex, alcohol abuse (over 80g/day), associated liver cirrhosis, persistent HBV infection (HBsAg), HCV infection (anti-HCV) and serum levels of alpha fetoprotein. 287 cases, over 16 years old, from 19 medical centers of 8 States (Pará, Bahia, Minas Gerais, Espirito Santo, Rio de Janeiro, São Paulo, Paraná and Rio Grande do Sul) were analysed. The results showed: (a) Mean age was 56.3 ± 14.4 for men and 54.7 ± 16.8 yr for women and the male/female ratio was 3.4:1. (b) 69.6% were caucasians, 21.8% mullatoes, 4.8% orientals and 3.7% blacks. (c) HBsAg (+) in 77/236 cases (41.6%) without differences between males and females. (d) Anti-HCV (+) in 52/193 cases (26.9%). (e) 7/180 cases were positive both for HBsAg and anti-HCV (3.8%). (f) There was chronic alcoholism in 88/235 cases (37%). (g) HCC was found in cirrhotic livers in 71.2% of 202 cases in which the presence or absence of cirrhosis was reported. (h) Alpha-fetoprotein above 20 ng/ml was found in 124/172 cases (72%) and above 500 ng/ml only in 40 cases (23.2%). These results showed that the HCC in Brazil has an intermediate epidemiological pattern as compared to those from areas of low and high incidence of the tumor. In spite of the high frequency of the association of HCC with the HBV and/or HCV infections, 42% of 180 cases were negative both for HBsAg and anti-HCV, indicating the possible role of other etiological factors. The comparison of data from different States showed some regional differences: higher frequency of associated HBsAg in Pará, Bahia, Minas Gerais and Espírito Santo, higher frequency of associated HCV infection in Rio de Janeiro, São Paulo and States of the Southern region and low frequency of associated liver cirrhosis in Salvador and Rio de Janeiro (55.5 and 50% ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Hepatocellular carcinoma Liver Tumors Liver Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Hepatocellular carcinoma Liver Tumors Liver Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 GONÇALVES Carlos S. PEREIRA Fausto E. L. Gayotto Luis C.C. Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995) |
topic_facet |
Hepatocellular carcinoma Liver Tumors Liver Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
In order to investigate epidemiological aspects of hepatocellular carcinoma (HCC) in Brazil, basic informations about cases diagnosed from January 1992 to December 1994 were requested to several medical centers of different Brazilian States. A simple questionnaire included age, sex, alcohol abuse (over 80g/day), associated liver cirrhosis, persistent HBV infection (HBsAg), HCV infection (anti-HCV) and serum levels of alpha fetoprotein. 287 cases, over 16 years old, from 19 medical centers of 8 States (Pará, Bahia, Minas Gerais, Espirito Santo, Rio de Janeiro, São Paulo, Paraná and Rio Grande do Sul) were analysed. The results showed: (a) Mean age was 56.3 ± 14.4 for men and 54.7 ± 16.8 yr for women and the male/female ratio was 3.4:1. (b) 69.6% were caucasians, 21.8% mullatoes, 4.8% orientals and 3.7% blacks. (c) HBsAg (+) in 77/236 cases (41.6%) without differences between males and females. (d) Anti-HCV (+) in 52/193 cases (26.9%). (e) 7/180 cases were positive both for HBsAg and anti-HCV (3.8%). (f) There was chronic alcoholism in 88/235 cases (37%). (g) HCC was found in cirrhotic livers in 71.2% of 202 cases in which the presence or absence of cirrhosis was reported. (h) Alpha-fetoprotein above 20 ng/ml was found in 124/172 cases (72%) and above 500 ng/ml only in 40 cases (23.2%). These results showed that the HCC in Brazil has an intermediate epidemiological pattern as compared to those from areas of low and high incidence of the tumor. In spite of the high frequency of the association of HCC with the HBV and/or HCV infections, 42% of 180 cases were negative both for HBsAg and anti-HCV, indicating the possible role of other etiological factors. The comparison of data from different States showed some regional differences: higher frequency of associated HBsAg in Pará, Bahia, Minas Gerais and Espírito Santo, higher frequency of associated HCV infection in Rio de Janeiro, São Paulo and States of the Southern region and low frequency of associated liver cirrhosis in Salvador and Rio de Janeiro (55.5 and 50% ... |
format |
Article in Journal/Newspaper |
author |
GONÇALVES Carlos S. PEREIRA Fausto E. L. Gayotto Luis C.C. |
author_facet |
GONÇALVES Carlos S. PEREIRA Fausto E. L. Gayotto Luis C.C. |
author_sort |
GONÇALVES Carlos S. |
title |
Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995) |
title_short |
Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995) |
title_full |
Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995) |
title_fullStr |
Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995) |
title_full_unstemmed |
Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995) |
title_sort |
hepatocellular carcinoma in brazil: report of a national survey (florianópolis, sc, 1995) |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1997 |
url |
https://doaj.org/article/6da23d789ee14f3eb7bbf5f706295b58 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 39, Iss 3, Pp 165-170 (1997) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000300008 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/6da23d789ee14f3eb7bbf5f706295b58 |
_version_ |
1809897835085168640 |