Mortality and its association with CD4 cell count and hemoglobin level among children on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis
Abstract Background Even though there are advancements in HIV/AIDS prevention and treatment approach, HIV continues to be a global challenge. Pediatrics HIV is one of the challenges in the reduction of child mortality particularly in less developed countries like Ethiopia. Therefore, this study aims...
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ftdoajarticles:oai:doaj.org/article:6d5fced7bf2c4ae6bcee312d537eab76 2023-05-15T15:18:03+02:00 Mortality and its association with CD4 cell count and hemoglobin level among children on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis Chalachew Adugna Wubneh Getaneh Mulualem Belay 2020-09-01T00:00:00Z https://doi.org/10.1186/s41182-020-00267-y https://doaj.org/article/6d5fced7bf2c4ae6bcee312d537eab76 EN eng BMC http://link.springer.com/article/10.1186/s41182-020-00267-y https://doaj.org/toc/1349-4147 doi:10.1186/s41182-020-00267-y 1349-4147 https://doaj.org/article/6d5fced7bf2c4ae6bcee312d537eab76 Tropical Medicine and Health, Vol 48, Iss 1, Pp 1-11 (2020) ART CD4 Children Ethiopia Hemoglobin Meta-analysis Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.1186/s41182-020-00267-y 2022-12-31T13:46:49Z Abstract Background Even though there are advancements in HIV/AIDS prevention and treatment approach, HIV continues to be a global challenge. Pediatrics HIV is one of the challenges in the reduction of child mortality particularly in less developed countries like Ethiopia. Therefore, this study aims to estimate the pooled proportion of child mortality and the effect of hemoglobin level and CD4 cell count among children on antiretroviral therapy in Ethiopia. Method All published were articles searched using PubMed, EMBASE, Google Scholar, and Web of Science database. Besides, Ethiopian institutional research repositories and reference lists of included studies were used. We limited the searching to studies conducted in Ethiopia and written in the English language. Studies that were done in a cohort, cross-sectional, and case-control study design were considered for the review. The weighted inverse variance random effects model was applied, and the overall variations between studies were checked by using heterogeneity test Higgins’s (I 2). Subgroup analysis by region and year of publication was conducted. All of the included articles were assessed using the Joanna Briggs Institute (JBI) quality appraisal criteria. In addition, publication bias was also checked with Egger’s regression test and the funnel plot. Based on the results, trim and fill analysis was performed to manage the publication bias. Result A total of 16 studies with 7047 participants were included in this systematic review and meta-analysis. The overall pooled proportion of mortality among children on antiretroviral therapy (ART) was found to be 11.78% (95% CI 9.34, 14.23). In subgroup analysis, the highest child mortality was observed in the Amhara region 16.76 % (95% CI 9.63, 23.90) and the lowest is in the Tigray region 4.81% (95% CI 2.75, 6.87). Besides, the proportion of mortality among children with low CD4 count and hemoglobin level was 2.42 (AOR = 2.42, 95% CI 1.65, 3.56) and 3.24 (AOR = 3.24, 95% CI 1.51, 6.93) times higher compared to ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Briggs ENVELOPE(-63.017,-63.017,-64.517,-64.517) Tropical Medicine and Health 48 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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ART CD4 Children Ethiopia Hemoglobin Meta-analysis Arctic medicine. Tropical medicine RC955-962 |
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ART CD4 Children Ethiopia Hemoglobin Meta-analysis Arctic medicine. Tropical medicine RC955-962 Chalachew Adugna Wubneh Getaneh Mulualem Belay Mortality and its association with CD4 cell count and hemoglobin level among children on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis |
topic_facet |
ART CD4 Children Ethiopia Hemoglobin Meta-analysis Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Even though there are advancements in HIV/AIDS prevention and treatment approach, HIV continues to be a global challenge. Pediatrics HIV is one of the challenges in the reduction of child mortality particularly in less developed countries like Ethiopia. Therefore, this study aims to estimate the pooled proportion of child mortality and the effect of hemoglobin level and CD4 cell count among children on antiretroviral therapy in Ethiopia. Method All published were articles searched using PubMed, EMBASE, Google Scholar, and Web of Science database. Besides, Ethiopian institutional research repositories and reference lists of included studies were used. We limited the searching to studies conducted in Ethiopia and written in the English language. Studies that were done in a cohort, cross-sectional, and case-control study design were considered for the review. The weighted inverse variance random effects model was applied, and the overall variations between studies were checked by using heterogeneity test Higgins’s (I 2). Subgroup analysis by region and year of publication was conducted. All of the included articles were assessed using the Joanna Briggs Institute (JBI) quality appraisal criteria. In addition, publication bias was also checked with Egger’s regression test and the funnel plot. Based on the results, trim and fill analysis was performed to manage the publication bias. Result A total of 16 studies with 7047 participants were included in this systematic review and meta-analysis. The overall pooled proportion of mortality among children on antiretroviral therapy (ART) was found to be 11.78% (95% CI 9.34, 14.23). In subgroup analysis, the highest child mortality was observed in the Amhara region 16.76 % (95% CI 9.63, 23.90) and the lowest is in the Tigray region 4.81% (95% CI 2.75, 6.87). Besides, the proportion of mortality among children with low CD4 count and hemoglobin level was 2.42 (AOR = 2.42, 95% CI 1.65, 3.56) and 3.24 (AOR = 3.24, 95% CI 1.51, 6.93) times higher compared to ... |
format |
Article in Journal/Newspaper |
author |
Chalachew Adugna Wubneh Getaneh Mulualem Belay |
author_facet |
Chalachew Adugna Wubneh Getaneh Mulualem Belay |
author_sort |
Chalachew Adugna Wubneh |
title |
Mortality and its association with CD4 cell count and hemoglobin level among children on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis |
title_short |
Mortality and its association with CD4 cell count and hemoglobin level among children on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis |
title_full |
Mortality and its association with CD4 cell count and hemoglobin level among children on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis |
title_fullStr |
Mortality and its association with CD4 cell count and hemoglobin level among children on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis |
title_full_unstemmed |
Mortality and its association with CD4 cell count and hemoglobin level among children on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis |
title_sort |
mortality and its association with cd4 cell count and hemoglobin level among children on antiretroviral therapy in ethiopia: a systematic review and meta-analysis |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s41182-020-00267-y https://doaj.org/article/6d5fced7bf2c4ae6bcee312d537eab76 |
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ENVELOPE(-63.017,-63.017,-64.517,-64.517) |
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Arctic Briggs |
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Arctic Briggs |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 48, Iss 1, Pp 1-11 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s41182-020-00267-y https://doaj.org/toc/1349-4147 doi:10.1186/s41182-020-00267-y 1349-4147 https://doaj.org/article/6d5fced7bf2c4ae6bcee312d537eab76 |
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https://doi.org/10.1186/s41182-020-00267-y |
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Tropical Medicine and Health |
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48 |
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1 |
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