Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti.
Background There is an increased need to mitigate the emergence of insecticide resistance and incorporate new formulations and modes of application to control the urban vector Aedes aegypti. Most research and development of insecticide formulations for the control of Ae. aegypti has focused on their...
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ftdoajarticles:oai:doaj.org/article:6d57818b41e946a68885babac04ff119 2023-05-15T15:16:41+02:00 Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti. Azael Che-Mendoza Gabriela González-Olvera Anuar Medina-Barreiro Carlos Arisqueta-Chablé Wilberth Bibiano-Marin Fabián Correa-Morales Oscar D Kirstein Pablo Manrique-Saide Gonzalo M Vazquez-Prokopec 2021-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009822 https://doaj.org/article/6d57818b41e946a68885babac04ff119 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009822 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009822 https://doaj.org/article/6d57818b41e946a68885babac04ff119 PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009822 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009822 2022-12-31T11:28:55Z Background There is an increased need to mitigate the emergence of insecticide resistance and incorporate new formulations and modes of application to control the urban vector Aedes aegypti. Most research and development of insecticide formulations for the control of Ae. aegypti has focused on their peridomestic use as truck-mounted ULV-sprays or thermal fogs despite the widespread knowledge that most resting Ae. aegypti are found indoors. A recent modification of indoor residual spraying (IRS), termed targeted IRS (TIRS) works by restricting applications to 1.5 m down to the floor and on key Ae. aegypti resting sites (under furniture). TIRS also opens the possibility of evaluating novel residual insecticide formulations currently being developed for malaria IRS. Methods We evaluated the residual efficacy of chlorfenapyr, formulated as Sylando 240SC, for 12 months on free-flying field-derived pyrethroid-resistant Ae. aegypti using a novel experimental house design in Merida, Mexico. On a monthly basis, 600 female Ae. aegypti were released into the houses and left indoors with access to sugar solution for 24 hours. After the exposure period, dead and alive mosquitoes were counted in houses treated with chlorfenapyr as well as untreated control houses to calculate 24-h mortality. An evaluation for these exposed cohorts of surviving mosquitoes was extended up to seven days under laboratory conditions to quantify "delayed mortality". Results Mean acute (24-h) mortality of pyrethroid-resistant Ae. aegypti ranged 80-97% over 5 months, dropping below 30% after 7 months post-TIRS. If delayed mortality was considered (quantifying mosquito mortality up to 7 days after exposure), residual efficacy was above 90% for up to 7 months post-TIRS application. Generalized Additive Mixed Models quantified a residual efficacy of chlorfenapyr of 225 days (ca. 7.5 months). Conclusions Chlorfenapyr represents a new option for TIRS control of Ae. aegypti in urban areas, providing a highly-effective time of protection against indoor Ae. ... Article in Journal/Newspaper Arctic ulv Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 10 e0009822 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Azael Che-Mendoza Gabriela González-Olvera Anuar Medina-Barreiro Carlos Arisqueta-Chablé Wilberth Bibiano-Marin Fabián Correa-Morales Oscar D Kirstein Pablo Manrique-Saide Gonzalo M Vazquez-Prokopec Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background There is an increased need to mitigate the emergence of insecticide resistance and incorporate new formulations and modes of application to control the urban vector Aedes aegypti. Most research and development of insecticide formulations for the control of Ae. aegypti has focused on their peridomestic use as truck-mounted ULV-sprays or thermal fogs despite the widespread knowledge that most resting Ae. aegypti are found indoors. A recent modification of indoor residual spraying (IRS), termed targeted IRS (TIRS) works by restricting applications to 1.5 m down to the floor and on key Ae. aegypti resting sites (under furniture). TIRS also opens the possibility of evaluating novel residual insecticide formulations currently being developed for malaria IRS. Methods We evaluated the residual efficacy of chlorfenapyr, formulated as Sylando 240SC, for 12 months on free-flying field-derived pyrethroid-resistant Ae. aegypti using a novel experimental house design in Merida, Mexico. On a monthly basis, 600 female Ae. aegypti were released into the houses and left indoors with access to sugar solution for 24 hours. After the exposure period, dead and alive mosquitoes were counted in houses treated with chlorfenapyr as well as untreated control houses to calculate 24-h mortality. An evaluation for these exposed cohorts of surviving mosquitoes was extended up to seven days under laboratory conditions to quantify "delayed mortality". Results Mean acute (24-h) mortality of pyrethroid-resistant Ae. aegypti ranged 80-97% over 5 months, dropping below 30% after 7 months post-TIRS. If delayed mortality was considered (quantifying mosquito mortality up to 7 days after exposure), residual efficacy was above 90% for up to 7 months post-TIRS application. Generalized Additive Mixed Models quantified a residual efficacy of chlorfenapyr of 225 days (ca. 7.5 months). Conclusions Chlorfenapyr represents a new option for TIRS control of Ae. aegypti in urban areas, providing a highly-effective time of protection against indoor Ae. ... |
format |
Article in Journal/Newspaper |
author |
Azael Che-Mendoza Gabriela González-Olvera Anuar Medina-Barreiro Carlos Arisqueta-Chablé Wilberth Bibiano-Marin Fabián Correa-Morales Oscar D Kirstein Pablo Manrique-Saide Gonzalo M Vazquez-Prokopec |
author_facet |
Azael Che-Mendoza Gabriela González-Olvera Anuar Medina-Barreiro Carlos Arisqueta-Chablé Wilberth Bibiano-Marin Fabián Correa-Morales Oscar D Kirstein Pablo Manrique-Saide Gonzalo M Vazquez-Prokopec |
author_sort |
Azael Che-Mendoza |
title |
Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti. |
title_short |
Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti. |
title_full |
Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti. |
title_fullStr |
Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti. |
title_full_unstemmed |
Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti. |
title_sort |
efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant aedes aegypti. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009822 https://doaj.org/article/6d57818b41e946a68885babac04ff119 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic ulv |
genre_facet |
Arctic ulv |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009822 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009822 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009822 https://doaj.org/article/6d57818b41e946a68885babac04ff119 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009822 |
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PLOS Neglected Tropical Diseases |
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15 |
container_issue |
10 |
container_start_page |
e0009822 |
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1766346981115953152 |