T-cell receptor variable region usage in Chagas disease: A systematic review of experimental and human studies

• Main Authors: Thaiany Goulart de Souza-Silva, Kenneth J. Gollob, Walderez O. Dutra
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2022
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Prisma; Will Point
• Online Access: https://doaj.org/article/6d3c31fa4a464701a96476cd17f666f7

T cells recognize their ligand, the peptide major histocompatibility complex (MHC), via the T-cell receptor (TCR), which is composed of covalently linked α and β or γ and δ chains. This recognition is critical for T-cell ontogeny and controls the selection, activation, and function of T lymphocytes....