β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats
Objective: To investigate the role of Mirabilis jalapa root extracts in restoration of glucose homeostasis in alloxan-induced hyperglycemic Wistar albino rats. Methods: Experimental hyperglycemic rats were treated daily with 200 and 400 mg/kg of Mirabilis jalapa extracts after initial fasting for 6...
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Wolters Kluwer Medknow Publications
2022
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Online Access: | https://doi.org/10.4103/2221-1691.350183 https://doaj.org/article/6d1de6cba09b4743b713a71f4a4c82b3 |
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ftdoajarticles:oai:doaj.org/article:6d1de6cba09b4743b713a71f4a4c82b3 2023-05-15T15:13:09+02:00 β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats Masud Eneji Sadiq Chibuzo Egwuenu Rabiu Saidu Umar Wasagu Usman Zayyanu Umar Bello Usman 2022-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.350183 https://doaj.org/article/6d1de6cba09b4743b713a71f4a4c82b3 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=8;spage=351;epage=356;aulast=Sadiq https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.350183 https://doaj.org/article/6d1de6cba09b4743b713a71f4a4c82b3 Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 8, Pp 351-356 (2022) mirabilis jalapa glucose toxicity diabetes mellitus hyperglycemia β-islet cell antioxidant rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2022 ftdoajarticles https://doi.org/10.4103/2221-1691.350183 2022-12-31T00:28:49Z Objective: To investigate the role of Mirabilis jalapa root extracts in restoration of glucose homeostasis in alloxan-induced hyperglycemic Wistar albino rats. Methods: Experimental hyperglycemic rats were treated daily with 200 and 400 mg/kg of Mirabilis jalapa extracts after initial fasting for 6 h. Two-hour postprandial glucose and changes in body weight were monitored during treatment. After 14 d, the rats were sacrificed and blood was collected for biochemical assessment of serum glucose and insulin levels, lipid profile, and oxidative stress markers. Histopathological examinations of harvested pancreas were also carried out. Results: Mirabilis jalapa root extracts at 200 and 400 mg/kg increased the body weight of hyperglycemic rats. Postprandial glucose levels of the extract-treated hyperglycemic groups progressively declined during treatment compared with the untreated hyperglycemic control group (P<0.05). The lipid profile indices of the untreated negative control group were significantly elevated (P<0.05), which were reversed by treatment with Mirabilis jalapa extracts. The remarkable increases in antioxidant enzyme activities and a significant decrease in malondialdehyde levels were observed in the hyperglycemic group treated with Mirabilis jalapa extracts. Mirabilis jalapa extracts also significantly increased serum insulin levels (P<0.05). In addition, histopathological examinations of the pancreas revealed a significant cell population within the islet nests of the extract-treated hyperglycemic groups. Conclusions: Mirabilis jalapa extract can restore glucose homeostasis and show hypoglycemic and hypolipidemic effects in hyperglycemic rats. Further studies are needed to verify the active components of the plant and the underlying mechanism of action in the future. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 12 8 351 |
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ftdoajarticles |
language |
English |
topic |
mirabilis jalapa glucose toxicity diabetes mellitus hyperglycemia β-islet cell antioxidant rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
mirabilis jalapa glucose toxicity diabetes mellitus hyperglycemia β-islet cell antioxidant rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Masud Eneji Sadiq Chibuzo Egwuenu Rabiu Saidu Umar Wasagu Usman Zayyanu Umar Bello Usman β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats |
topic_facet |
mirabilis jalapa glucose toxicity diabetes mellitus hyperglycemia β-islet cell antioxidant rat Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the role of Mirabilis jalapa root extracts in restoration of glucose homeostasis in alloxan-induced hyperglycemic Wistar albino rats. Methods: Experimental hyperglycemic rats were treated daily with 200 and 400 mg/kg of Mirabilis jalapa extracts after initial fasting for 6 h. Two-hour postprandial glucose and changes in body weight were monitored during treatment. After 14 d, the rats were sacrificed and blood was collected for biochemical assessment of serum glucose and insulin levels, lipid profile, and oxidative stress markers. Histopathological examinations of harvested pancreas were also carried out. Results: Mirabilis jalapa root extracts at 200 and 400 mg/kg increased the body weight of hyperglycemic rats. Postprandial glucose levels of the extract-treated hyperglycemic groups progressively declined during treatment compared with the untreated hyperglycemic control group (P<0.05). The lipid profile indices of the untreated negative control group were significantly elevated (P<0.05), which were reversed by treatment with Mirabilis jalapa extracts. The remarkable increases in antioxidant enzyme activities and a significant decrease in malondialdehyde levels were observed in the hyperglycemic group treated with Mirabilis jalapa extracts. Mirabilis jalapa extracts also significantly increased serum insulin levels (P<0.05). In addition, histopathological examinations of the pancreas revealed a significant cell population within the islet nests of the extract-treated hyperglycemic groups. Conclusions: Mirabilis jalapa extract can restore glucose homeostasis and show hypoglycemic and hypolipidemic effects in hyperglycemic rats. Further studies are needed to verify the active components of the plant and the underlying mechanism of action in the future. |
format |
Article in Journal/Newspaper |
author |
Masud Eneji Sadiq Chibuzo Egwuenu Rabiu Saidu Umar Wasagu Usman Zayyanu Umar Bello Usman |
author_facet |
Masud Eneji Sadiq Chibuzo Egwuenu Rabiu Saidu Umar Wasagu Usman Zayyanu Umar Bello Usman |
author_sort |
Masud Eneji Sadiq |
title |
β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats |
title_short |
β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats |
title_full |
β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats |
title_fullStr |
β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats |
title_full_unstemmed |
β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats |
title_sort |
β-islet cell regeneration potential of mirabilis jalapa in hyperglycemic rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2022 |
url |
https://doi.org/10.4103/2221-1691.350183 https://doaj.org/article/6d1de6cba09b4743b713a71f4a4c82b3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 8, Pp 351-356 (2022) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=8;spage=351;epage=356;aulast=Sadiq https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.350183 https://doaj.org/article/6d1de6cba09b4743b713a71f4a4c82b3 |
op_doi |
https://doi.org/10.4103/2221-1691.350183 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
12 |
container_issue |
8 |
container_start_page |
351 |
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1766343742857412608 |