Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018.
Introduction Acute Q fever is endemic in Israel, yet the clinical and laboratory picture is poorly defined. Methods A retrospective study reviewing the medical records of acute Q fever patients, conducted in a single hospital in the Sharon district, Israel. Serum samples from suspected cases were pr...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0009573 https://doaj.org/article/6d17794663aa42ffa5b1bebeb17cecc1 |
id |
ftdoajarticles:oai:doaj.org/article:6d17794663aa42ffa5b1bebeb17cecc1 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:6d17794663aa42ffa5b1bebeb17cecc1 2023-05-15T15:12:51+02:00 Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018. Talya Finn Frida Babushkin Keren Geller Hanna Alexander Svetlana Paikin Jonathan Lellouche Yafit Atiya-Nasagi Regev Cohen 2021-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009573 https://doaj.org/article/6d17794663aa42ffa5b1bebeb17cecc1 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009573 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009573 https://doaj.org/article/6d17794663aa42ffa5b1bebeb17cecc1 PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009573 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009573 2022-12-31T07:42:56Z Introduction Acute Q fever is endemic in Israel, yet the clinical and laboratory picture is poorly defined. Methods A retrospective study reviewing the medical records of acute Q fever patients, conducted in a single hospital in the Sharon district, Israel. Serum samples from suspected cases were preliminary tested by a qualitative enzyme immunoassay (EIA). Confirmatory testing at the reference laboratory used an indirect immunofluorescence assay (IFA). Positive cases were defined as fever with at least one other symptom and accepted laboratory criteria such as a single-phase II immunoglobulin G (IgG) antibody titer ≥1:200. Cases not fulfilling these criteria and in which acute Q fever was excluded, served as a control group. Results Between January 2012 and May 2018, 484 patients tested positive. After confirmatory testing, 65 (13.4%) were positive for acute Q fever (with requisite clinical picture), 171 (35.3%) were definitely not infected, the remaining 248 were excluded because of past/chronic/undetermined infection. The average age was 58 years and 66% were males. Most resided in urban areas with rare animal exposure. Pneumonia was seen in 57% of cases and a combination with headache/hepatitis was highly suggestive of acute Q fever diagnosis. Syncope/presyncope, fall and arthritis were more common in acute Q fever cases. Laboratory indexes were similar to the control group, except for erythrocyte sedimentation rate (ESR) which was more common and higher in the study group. Conclusion Acute Q fever in the Sharon district could be better diagnosed by using a syndromic approach in combination with improved rapid diagnostic testing. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Eia ENVELOPE(7.755,7.755,63.024,63.024) PLOS Neglected Tropical Diseases 15 7 e0009573 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Talya Finn Frida Babushkin Keren Geller Hanna Alexander Svetlana Paikin Jonathan Lellouche Yafit Atiya-Nasagi Regev Cohen Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Introduction Acute Q fever is endemic in Israel, yet the clinical and laboratory picture is poorly defined. Methods A retrospective study reviewing the medical records of acute Q fever patients, conducted in a single hospital in the Sharon district, Israel. Serum samples from suspected cases were preliminary tested by a qualitative enzyme immunoassay (EIA). Confirmatory testing at the reference laboratory used an indirect immunofluorescence assay (IFA). Positive cases were defined as fever with at least one other symptom and accepted laboratory criteria such as a single-phase II immunoglobulin G (IgG) antibody titer ≥1:200. Cases not fulfilling these criteria and in which acute Q fever was excluded, served as a control group. Results Between January 2012 and May 2018, 484 patients tested positive. After confirmatory testing, 65 (13.4%) were positive for acute Q fever (with requisite clinical picture), 171 (35.3%) were definitely not infected, the remaining 248 were excluded because of past/chronic/undetermined infection. The average age was 58 years and 66% were males. Most resided in urban areas with rare animal exposure. Pneumonia was seen in 57% of cases and a combination with headache/hepatitis was highly suggestive of acute Q fever diagnosis. Syncope/presyncope, fall and arthritis were more common in acute Q fever cases. Laboratory indexes were similar to the control group, except for erythrocyte sedimentation rate (ESR) which was more common and higher in the study group. Conclusion Acute Q fever in the Sharon district could be better diagnosed by using a syndromic approach in combination with improved rapid diagnostic testing. |
format |
Article in Journal/Newspaper |
author |
Talya Finn Frida Babushkin Keren Geller Hanna Alexander Svetlana Paikin Jonathan Lellouche Yafit Atiya-Nasagi Regev Cohen |
author_facet |
Talya Finn Frida Babushkin Keren Geller Hanna Alexander Svetlana Paikin Jonathan Lellouche Yafit Atiya-Nasagi Regev Cohen |
author_sort |
Talya Finn |
title |
Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018. |
title_short |
Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018. |
title_full |
Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018. |
title_fullStr |
Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018. |
title_full_unstemmed |
Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018. |
title_sort |
epidemiological, clinical and laboratory features of acute q fever in a cohort of hospitalized patients in a regional hospital, israel, 2012-2018. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009573 https://doaj.org/article/6d17794663aa42ffa5b1bebeb17cecc1 |
long_lat |
ENVELOPE(7.755,7.755,63.024,63.024) |
geographic |
Arctic Eia |
geographic_facet |
Arctic Eia |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009573 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009573 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009573 https://doaj.org/article/6d17794663aa42ffa5b1bebeb17cecc1 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009573 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
7 |
container_start_page |
e0009573 |
_version_ |
1766343487682248704 |