Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury
Objective: To evaluate the toxic potential of Launaea taraxacifolia leaf extract (LTE) in rats within 14 d of oral administration and also assess the potential of LTE in protecting against kidney injury induced by gentamicin using rat model. Methods: The protective ability of LTE was done after sub-...
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Wolters Kluwer Medknow Publications
2017
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ftdoajarticles:oai:doaj.org/article:6d0e7dc1a5af444c9d64d342459009be 2023-05-15T15:11:20+02:00 Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury Lydia Enyonam Kuatsienu Charles Ansah Michael Buenor Adinortey 2017-07-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2017.06.011 https://doaj.org/article/6d0e7dc1a5af444c9d64d342459009be EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169117304902 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2017.06.011 https://doaj.org/article/6d0e7dc1a5af444c9d64d342459009be Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 7, Pp 640-646 (2017) Nephrotoxicity Launaea taraxacifolia Gentamicin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2017 ftdoajarticles https://doi.org/10.1016/j.apjtb.2017.06.011 2022-12-31T02:43:25Z Objective: To evaluate the toxic potential of Launaea taraxacifolia leaf extract (LTE) in rats within 14 d of oral administration and also assess the potential of LTE in protecting against kidney injury induced by gentamicin using rat model. Methods: The protective ability of LTE was done after sub-acute toxicity evaluation has been carried out. Acute Kidney Injury (AKI) was induced by gentamicin at a dose of 160 mg/kg intraperitoneal i.p. Parameters and indicators considered include mortality, clinical signs, body and organ weights, haematological and clinical chemistry parameters. Gross examination and histopathological assessment was also done on selected internal organs. Results: There were no treatment-related deaths or changes in clinical signs, haematological and clinical chemistry indices during sub-acute toxicity studies with the exception of creatinine levels. This was confirmed by micrographs obtained from histopathological analysis. Co-administration of LTE with 160 mg/kg of gentamicin (i.p) markedly decreased the levels of urea and creatinine when compared to negative control group. Histological studies of kidney tissues showed an insignificant change in tubular epithelium in LTE plus gentamicin treated group compared to LTE treated only. Conclusions: Data obtained show that ethanolic leaf extract of Launaea taraxacifolia is non-toxic within a 14 d administration at a maximum dose of 1000 mg/kg bwt and also possesses the ability to protect against gentamicin-induced kidney damage in rats at a dose of 300 mg/kg bwt. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 7 7 640 646 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Nephrotoxicity Launaea taraxacifolia Gentamicin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Nephrotoxicity Launaea taraxacifolia Gentamicin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Lydia Enyonam Kuatsienu Charles Ansah Michael Buenor Adinortey Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury |
topic_facet |
Nephrotoxicity Launaea taraxacifolia Gentamicin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the toxic potential of Launaea taraxacifolia leaf extract (LTE) in rats within 14 d of oral administration and also assess the potential of LTE in protecting against kidney injury induced by gentamicin using rat model. Methods: The protective ability of LTE was done after sub-acute toxicity evaluation has been carried out. Acute Kidney Injury (AKI) was induced by gentamicin at a dose of 160 mg/kg intraperitoneal i.p. Parameters and indicators considered include mortality, clinical signs, body and organ weights, haematological and clinical chemistry parameters. Gross examination and histopathological assessment was also done on selected internal organs. Results: There were no treatment-related deaths or changes in clinical signs, haematological and clinical chemistry indices during sub-acute toxicity studies with the exception of creatinine levels. This was confirmed by micrographs obtained from histopathological analysis. Co-administration of LTE with 160 mg/kg of gentamicin (i.p) markedly decreased the levels of urea and creatinine when compared to negative control group. Histological studies of kidney tissues showed an insignificant change in tubular epithelium in LTE plus gentamicin treated group compared to LTE treated only. Conclusions: Data obtained show that ethanolic leaf extract of Launaea taraxacifolia is non-toxic within a 14 d administration at a maximum dose of 1000 mg/kg bwt and also possesses the ability to protect against gentamicin-induced kidney damage in rats at a dose of 300 mg/kg bwt. |
format |
Article in Journal/Newspaper |
author |
Lydia Enyonam Kuatsienu Charles Ansah Michael Buenor Adinortey |
author_facet |
Lydia Enyonam Kuatsienu Charles Ansah Michael Buenor Adinortey |
author_sort |
Lydia Enyonam Kuatsienu |
title |
Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury |
title_short |
Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury |
title_full |
Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury |
title_fullStr |
Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury |
title_full_unstemmed |
Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury |
title_sort |
toxicological evaluation and protective effect of ethanolic leaf extract of launaea taraxacifolia on gentamicin induced rat kidney injury |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.apjtb.2017.06.011 https://doaj.org/article/6d0e7dc1a5af444c9d64d342459009be |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 7, Pp 640-646 (2017) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169117304902 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2017.06.011 https://doaj.org/article/6d0e7dc1a5af444c9d64d342459009be |
op_doi |
https://doi.org/10.1016/j.apjtb.2017.06.011 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
7 |
container_issue |
7 |
container_start_page |
640 |
op_container_end_page |
646 |
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1766342208223444992 |