Mycetoma at a tertiary care hospital in Saudi Arabia: correlation of histopathological and clinical findings
Objective: To present the histopathological and clinical correlation of mycetoma among patients attending King Abdulaziz University Hospital between 1998-2013. Methods: The data of all histopathologically diagnosed mycetomas in the period between January 1998 and January 2013 were collected through...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:6ccb3662137f46b3b45fda33e6f8429f 2023-05-15T15:09:32+02:00 Mycetoma at a tertiary care hospital in Saudi Arabia: correlation of histopathological and clinical findings Shagufta Tahir Mufti Hessa Aljhdali 2015-04-01T00:00:00Z https://doi.org/10.1016/S2221-1691(15)30353-1 https://doaj.org/article/6ccb3662137f46b3b45fda33e6f8429f EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115303531 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30353-1 https://doaj.org/article/6ccb3662137f46b3b45fda33e6f8429f Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 4, Pp 331-336 (2015) Mycetoma Madura Cementing matrix Actinomycetoma Saudi Arabia 16S rDNA Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/S2221-1691(15)30353-1 2022-12-31T00:31:14Z Objective: To present the histopathological and clinical correlation of mycetoma among patients attending King Abdulaziz University Hospital between 1998-2013. Methods: The data of all histopathologically diagnosed mycetomas in the period between January 1998 and January 2013 were collected through a computerized database search of the anatomic pathology archives at King Abdulaziz University Hospital. The collected data were analysed. Identification of species were performed for five patients using 16S ribosomal DNA and internal transcribed spacer 2. Results: There were 19 patients with mycetoma with an average age of 44.26 years and male: female ratio of 4:1. Actinomycetoma were 63.15% and eumycetoma were 36.84%. All patients presented with the classic lesions; presenting as painless subcutaneous mass, sinuses and discharge containing grains. The swellings were of slow evolution, with preferential foot localization. Species specification performed for samples from five patients with active lesions revealed species of Actinomyces israelii and Madurella mycetomatis in respective cases. Conclusions: Actinomycetoma is more common than eumycetoma in this region. The fact that one of the patients with eumycetoma was a Saudi national raises the possibility of an indigenous species similar to Maduraella mycetomatis to be further explored for characteristics and pathogenesis. The disease has to be prioritized again and more robust and quick molecular diagnostic tools should be made available in order to save patients form disfiguring amputations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 4 331 336 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Mycetoma Madura Cementing matrix Actinomycetoma Saudi Arabia 16S rDNA Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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Mycetoma Madura Cementing matrix Actinomycetoma Saudi Arabia 16S rDNA Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Shagufta Tahir Mufti Hessa Aljhdali Mycetoma at a tertiary care hospital in Saudi Arabia: correlation of histopathological and clinical findings |
topic_facet |
Mycetoma Madura Cementing matrix Actinomycetoma Saudi Arabia 16S rDNA Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To present the histopathological and clinical correlation of mycetoma among patients attending King Abdulaziz University Hospital between 1998-2013. Methods: The data of all histopathologically diagnosed mycetomas in the period between January 1998 and January 2013 were collected through a computerized database search of the anatomic pathology archives at King Abdulaziz University Hospital. The collected data were analysed. Identification of species were performed for five patients using 16S ribosomal DNA and internal transcribed spacer 2. Results: There were 19 patients with mycetoma with an average age of 44.26 years and male: female ratio of 4:1. Actinomycetoma were 63.15% and eumycetoma were 36.84%. All patients presented with the classic lesions; presenting as painless subcutaneous mass, sinuses and discharge containing grains. The swellings were of slow evolution, with preferential foot localization. Species specification performed for samples from five patients with active lesions revealed species of Actinomyces israelii and Madurella mycetomatis in respective cases. Conclusions: Actinomycetoma is more common than eumycetoma in this region. The fact that one of the patients with eumycetoma was a Saudi national raises the possibility of an indigenous species similar to Maduraella mycetomatis to be further explored for characteristics and pathogenesis. The disease has to be prioritized again and more robust and quick molecular diagnostic tools should be made available in order to save patients form disfiguring amputations. |
format |
Article in Journal/Newspaper |
author |
Shagufta Tahir Mufti Hessa Aljhdali |
author_facet |
Shagufta Tahir Mufti Hessa Aljhdali |
author_sort |
Shagufta Tahir Mufti |
title |
Mycetoma at a tertiary care hospital in Saudi Arabia: correlation of histopathological and clinical findings |
title_short |
Mycetoma at a tertiary care hospital in Saudi Arabia: correlation of histopathological and clinical findings |
title_full |
Mycetoma at a tertiary care hospital in Saudi Arabia: correlation of histopathological and clinical findings |
title_fullStr |
Mycetoma at a tertiary care hospital in Saudi Arabia: correlation of histopathological and clinical findings |
title_full_unstemmed |
Mycetoma at a tertiary care hospital in Saudi Arabia: correlation of histopathological and clinical findings |
title_sort |
mycetoma at a tertiary care hospital in saudi arabia: correlation of histopathological and clinical findings |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/S2221-1691(15)30353-1 https://doaj.org/article/6ccb3662137f46b3b45fda33e6f8429f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 4, Pp 331-336 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115303531 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30353-1 https://doaj.org/article/6ccb3662137f46b3b45fda33e6f8429f |
op_doi |
https://doi.org/10.1016/S2221-1691(15)30353-1 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
4 |
container_start_page |
331 |
op_container_end_page |
336 |
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1766340716712165376 |