Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite
Snake antivenom is a specific antidote to the venom action, neutralizing the circulating venom. However, it fails to neutralize the venom fixed to target organs such as platelets, renal tubules, etc. Russell's viper venom initiates rapid coagulation in a victim by activating blood platelets, fa...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1590/S1678-91992006000100011 https://doaj.org/article/6cc5099c793f4cddb4f1cd7bf3cf3dd0 |
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ftdoajarticles:oai:doaj.org/article:6cc5099c793f4cddb4f1cd7bf3cf3dd0 2023-05-15T15:01:28+02:00 Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite H. S. Bawaskar 2006-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992006000100011 https://doaj.org/article/6cc5099c793f4cddb4f1cd7bf3cf3dd0 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100011 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000100011 1678-9199 https://doaj.org/article/6cc5099c793f4cddb4f1cd7bf3cf3dd0 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 1, Pp 137-141 (2006) Russell's viper coagulation fibrinolysis aspirin clopidogrel Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2006 ftdoajarticles https://doi.org/10.1590/S1678-91992006000100011 2022-12-31T15:58:29Z Snake antivenom is a specific antidote to the venom action, neutralizing the circulating venom. However, it fails to neutralize the venom fixed to target organs such as platelets, renal tubules, etc. Russell's viper venom initiates rapid coagulation in a victim by activating blood platelets, factors V, X, and anticoagulant cofactors. Activation of thrombin, resulting in formation of micro-thrombi, fibrinolysis, and a vicious cascade, sets in. Inhibition of activated platelets by aspirin (cyclooxygenase inhibitor) and clopidogrel (ADP receptor inhibitor) helps to break this vicious circle induced by Russell's venom and may initiate the natural physiological clotting mechanism. They can be utilized as an adjuvant treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 12 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Russell's viper coagulation fibrinolysis aspirin clopidogrel Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Russell's viper coagulation fibrinolysis aspirin clopidogrel Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 H. S. Bawaskar Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite |
topic_facet |
Russell's viper coagulation fibrinolysis aspirin clopidogrel Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Snake antivenom is a specific antidote to the venom action, neutralizing the circulating venom. However, it fails to neutralize the venom fixed to target organs such as platelets, renal tubules, etc. Russell's viper venom initiates rapid coagulation in a victim by activating blood platelets, factors V, X, and anticoagulant cofactors. Activation of thrombin, resulting in formation of micro-thrombi, fibrinolysis, and a vicious cascade, sets in. Inhibition of activated platelets by aspirin (cyclooxygenase inhibitor) and clopidogrel (ADP receptor inhibitor) helps to break this vicious circle induced by Russell's venom and may initiate the natural physiological clotting mechanism. They can be utilized as an adjuvant treatment. |
format |
Article in Journal/Newspaper |
author |
H. S. Bawaskar |
author_facet |
H. S. Bawaskar |
author_sort |
H. S. Bawaskar |
title |
Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite |
title_short |
Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite |
title_full |
Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite |
title_fullStr |
Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite |
title_full_unstemmed |
Novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite |
title_sort |
novel role of antiplatelet agents (aspirin plus clopidogrel) in an incoagulable blood of a victim of russell's viper snakebite |
publisher |
SciELO |
publishDate |
2006 |
url |
https://doi.org/10.1590/S1678-91992006000100011 https://doaj.org/article/6cc5099c793f4cddb4f1cd7bf3cf3dd0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 1, Pp 137-141 (2006) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100011 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000100011 1678-9199 https://doaj.org/article/6cc5099c793f4cddb4f1cd7bf3cf3dd0 |
op_doi |
https://doi.org/10.1590/S1678-91992006000100011 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
12 |
container_issue |
1 |
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1766333490202148864 |