American Visceral Leishmaniasis: Factors Associated with Lethality in the State of São Paulo, Brazil
Objectives. To identify factors associated with death in visceral leishmaniasis (VL) cases. Patients and Methodology. We evaluated prognostic factors for death from VL in São Paulo state, Brazil, from 1999 to 2005. A prognostic study nested in a clinical cohort was carried out by data analysis of 37...
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ftdoajarticles:oai:doaj.org/article:6c9cbf3b9aa340618dceedd07ac9490b 2024-09-09T19:26:14+00:00 American Visceral Leishmaniasis: Factors Associated with Lethality in the State of São Paulo, Brazil Geraldine Madalosso Carlos Magno Fortaleza Ana Freitas Ribeiro Lisete Lage Cruz Péricles Alves Nogueira José Angelo Lauletta Lindoso 2012-01-01T00:00:00Z https://doi.org/10.1155/2012/281572 https://doaj.org/article/6c9cbf3b9aa340618dceedd07ac9490b EN eng Wiley http://dx.doi.org/10.1155/2012/281572 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/281572 https://doaj.org/article/6c9cbf3b9aa340618dceedd07ac9490b Journal of Tropical Medicine, Vol 2012 (2012) Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1155/2012/281572 2024-08-05T17:48:44Z Objectives. To identify factors associated with death in visceral leishmaniasis (VL) cases. Patients and Methodology. We evaluated prognostic factors for death from VL in São Paulo state, Brazil, from 1999 to 2005. A prognostic study nested in a clinical cohort was carried out by data analysis of 376 medical files. A comparison between VL fatal cases and survivors was performed for clinical, laboratory, and biological features. Association between variables and death was assessed by univariate analysis, and the multiple logistic regression model was used to determine adjusted odds ratio for death, controlling confounding factors. Results. Data analysis identified 53 fatal cases out of 376 patients, between 1999 and 2005 in São Paulo state. Lethality was 14.1% (53/376), being higher in patients older than fifty years. The main causes of death were sepsis, bleeding, liver failure, and cardiotoxicity due to treatment. Variables significantly associated with death were severe anemia, bleeding, heart failure, jaundice, diarrhea, fever for more than sixty days, age older than fifty years, and antibiotic use. Conclusion. Educational health measures are needed for the general population and continuing education programs for health professionals working in the affected areas with the purpose of identifying and treating early cases, thus preventing the disease evolution towards death. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2012 1 7 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Geraldine Madalosso Carlos Magno Fortaleza Ana Freitas Ribeiro Lisete Lage Cruz Péricles Alves Nogueira José Angelo Lauletta Lindoso American Visceral Leishmaniasis: Factors Associated with Lethality in the State of São Paulo, Brazil |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Objectives. To identify factors associated with death in visceral leishmaniasis (VL) cases. Patients and Methodology. We evaluated prognostic factors for death from VL in São Paulo state, Brazil, from 1999 to 2005. A prognostic study nested in a clinical cohort was carried out by data analysis of 376 medical files. A comparison between VL fatal cases and survivors was performed for clinical, laboratory, and biological features. Association between variables and death was assessed by univariate analysis, and the multiple logistic regression model was used to determine adjusted odds ratio for death, controlling confounding factors. Results. Data analysis identified 53 fatal cases out of 376 patients, between 1999 and 2005 in São Paulo state. Lethality was 14.1% (53/376), being higher in patients older than fifty years. The main causes of death were sepsis, bleeding, liver failure, and cardiotoxicity due to treatment. Variables significantly associated with death were severe anemia, bleeding, heart failure, jaundice, diarrhea, fever for more than sixty days, age older than fifty years, and antibiotic use. Conclusion. Educational health measures are needed for the general population and continuing education programs for health professionals working in the affected areas with the purpose of identifying and treating early cases, thus preventing the disease evolution towards death. |
format |
Article in Journal/Newspaper |
author |
Geraldine Madalosso Carlos Magno Fortaleza Ana Freitas Ribeiro Lisete Lage Cruz Péricles Alves Nogueira José Angelo Lauletta Lindoso |
author_facet |
Geraldine Madalosso Carlos Magno Fortaleza Ana Freitas Ribeiro Lisete Lage Cruz Péricles Alves Nogueira José Angelo Lauletta Lindoso |
author_sort |
Geraldine Madalosso |
title |
American Visceral Leishmaniasis: Factors Associated with Lethality in the State of São Paulo, Brazil |
title_short |
American Visceral Leishmaniasis: Factors Associated with Lethality in the State of São Paulo, Brazil |
title_full |
American Visceral Leishmaniasis: Factors Associated with Lethality in the State of São Paulo, Brazil |
title_fullStr |
American Visceral Leishmaniasis: Factors Associated with Lethality in the State of São Paulo, Brazil |
title_full_unstemmed |
American Visceral Leishmaniasis: Factors Associated with Lethality in the State of São Paulo, Brazil |
title_sort |
american visceral leishmaniasis: factors associated with lethality in the state of são paulo, brazil |
publisher |
Wiley |
publishDate |
2012 |
url |
https://doi.org/10.1155/2012/281572 https://doaj.org/article/6c9cbf3b9aa340618dceedd07ac9490b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2012 (2012) |
op_relation |
http://dx.doi.org/10.1155/2012/281572 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/281572 https://doaj.org/article/6c9cbf3b9aa340618dceedd07ac9490b |
op_doi |
https://doi.org/10.1155/2012/281572 |
container_title |
Journal of Tropical Medicine |
container_volume |
2012 |
container_start_page |
1 |
op_container_end_page |
7 |
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1809895888104980480 |