Anti-diabetic properties and bioactive compounds of Teucrium polium L.
Diabetes mellitus is a common metabolic disease with considerable morbidity and mortality. Untreated or improperly-treated diabetes can be associated with several long-term complications that necessitate an effective way to manage diabetes. Due to the side effects of synthetic glucose-lowering agent...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2020
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ftdoajarticles:oai:doaj.org/article:6c6cd4e541af4d64b346f4adf2ca3d5e 2023-05-15T15:10:05+02:00 Anti-diabetic properties and bioactive compounds of Teucrium polium L. Ali Akbar Asghari Amin Mokhtari-Zaer Saeed Niazmand Kathleen Mc Entee Maryam Mahmoudabady 2020-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.290868 https://doaj.org/article/6c6cd4e541af4d64b346f4adf2ca3d5e EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=10;spage=433;epage=441;aulast=Asghari https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.290868 https://doaj.org/article/6c6cd4e541af4d64b346f4adf2ca3d5e Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 10, Pp 433-441 (2020) teucrium polium l. diabetes mellitus oxidative stress inflammation Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2020 ftdoajarticles https://doi.org/10.4103/2221-1691.290868 2022-12-31T01:13:09Z Diabetes mellitus is a common metabolic disease with considerable morbidity and mortality. Untreated or improperly-treated diabetes can be associated with several long-term complications that necessitate an effective way to manage diabetes. Due to the side effects of synthetic glucose-lowering agents, alternative therapeutic modalities such as medicinal plants have attracted notable attention. Teucrium polium L. is a medicinal herb with antioxidant, antinociceptive, anti-inflammatory, hypolipidemic, hepatoprotective, and hypoglycemic properties. In vitro and in vivo studies have been conducted to characterize the anti-diabetic properties of Teucrium polium L. and its bioactive compounds. We conducted a literature study using Scopus, PubMed, and Google Scholar including the keywords “diabetes” and “Teucrium polium”. We also scanned all the references cited by the retrieved articles. According to this review, Teucrium polium administration displayed anti-diabetic effects by targeting different mechanisms and pathways, such as enhancement of insulin secretion and insulin level, improvement of oxidative damage, regeneration of pancreatic β-cells, and promotion of glucose uptake in muscle tissues by increasing GLUT-4 translocation as well as inhibiting α-amylase activity. Although Teucrium polium has been widely regarded as a traditional method, the pharmacological studies on anti-diabetic effects are not sufficient, most studies are either in-vivo or in-vitro. The preclinical and clinical studies are further required to confirm the efficacy of Teucrium polium. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 10 10 433 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
teucrium polium l. diabetes mellitus oxidative stress inflammation Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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teucrium polium l. diabetes mellitus oxidative stress inflammation Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Ali Akbar Asghari Amin Mokhtari-Zaer Saeed Niazmand Kathleen Mc Entee Maryam Mahmoudabady Anti-diabetic properties and bioactive compounds of Teucrium polium L. |
topic_facet |
teucrium polium l. diabetes mellitus oxidative stress inflammation Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Diabetes mellitus is a common metabolic disease with considerable morbidity and mortality. Untreated or improperly-treated diabetes can be associated with several long-term complications that necessitate an effective way to manage diabetes. Due to the side effects of synthetic glucose-lowering agents, alternative therapeutic modalities such as medicinal plants have attracted notable attention. Teucrium polium L. is a medicinal herb with antioxidant, antinociceptive, anti-inflammatory, hypolipidemic, hepatoprotective, and hypoglycemic properties. In vitro and in vivo studies have been conducted to characterize the anti-diabetic properties of Teucrium polium L. and its bioactive compounds. We conducted a literature study using Scopus, PubMed, and Google Scholar including the keywords “diabetes” and “Teucrium polium”. We also scanned all the references cited by the retrieved articles. According to this review, Teucrium polium administration displayed anti-diabetic effects by targeting different mechanisms and pathways, such as enhancement of insulin secretion and insulin level, improvement of oxidative damage, regeneration of pancreatic β-cells, and promotion of glucose uptake in muscle tissues by increasing GLUT-4 translocation as well as inhibiting α-amylase activity. Although Teucrium polium has been widely regarded as a traditional method, the pharmacological studies on anti-diabetic effects are not sufficient, most studies are either in-vivo or in-vitro. The preclinical and clinical studies are further required to confirm the efficacy of Teucrium polium. |
format |
Article in Journal/Newspaper |
author |
Ali Akbar Asghari Amin Mokhtari-Zaer Saeed Niazmand Kathleen Mc Entee Maryam Mahmoudabady |
author_facet |
Ali Akbar Asghari Amin Mokhtari-Zaer Saeed Niazmand Kathleen Mc Entee Maryam Mahmoudabady |
author_sort |
Ali Akbar Asghari |
title |
Anti-diabetic properties and bioactive compounds of Teucrium polium L. |
title_short |
Anti-diabetic properties and bioactive compounds of Teucrium polium L. |
title_full |
Anti-diabetic properties and bioactive compounds of Teucrium polium L. |
title_fullStr |
Anti-diabetic properties and bioactive compounds of Teucrium polium L. |
title_full_unstemmed |
Anti-diabetic properties and bioactive compounds of Teucrium polium L. |
title_sort |
anti-diabetic properties and bioactive compounds of teucrium polium l. |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/2221-1691.290868 https://doaj.org/article/6c6cd4e541af4d64b346f4adf2ca3d5e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 10, Iss 10, Pp 433-441 (2020) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=10;spage=433;epage=441;aulast=Asghari https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.290868 https://doaj.org/article/6c6cd4e541af4d64b346f4adf2ca3d5e |
op_doi |
https://doi.org/10.4103/2221-1691.290868 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
10 |
container_issue |
10 |
container_start_page |
433 |
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