Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis.
Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this approach involves modification of the commensal...
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ftdoajarticles:oai:doaj.org/article:6c46add28d904516ab1c4e4087d00f9c 2023-05-15T15:03:58+02:00 Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. Jan Medlock Katherine E Atkins David N Thomas Serap Aksoy Alison P Galvani 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002374 https://doaj.org/article/6c46add28d904516ab1c4e4087d00f9c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3744416?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002374 https://doaj.org/article/6c46add28d904516ab1c4e4087d00f9c PLoS Neglected Tropical Diseases, Vol 7, Iss 8, p e2374 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002374 2022-12-31T12:37:29Z Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this approach involves modification of the commensal symbiotic bacteria Sodalis to express trypanosome-resistance-conferring products. Modified Sodalis can then be driven into the tsetse population by cytoplasmic incompatibility (CI) from Wolbachia bacteria. To evaluate the effectiveness of this paratransgenic strategy in controlling African trypanosomiasis, we developed a three-species mathematical model of trypanosomiasis transmission among tsetse, humans, and animal reservoir hosts. Using empirical estimates of CI parameters, we found that paratransgenic tsetse have the potential to eliminate trypanosomiasis, provided that any extra mortality caused by Wolbachia colonization is low, that the paratransgene is effective at protecting against trypanosome transmission, and that the target tsetse species comprises a large majority of the tsetse population in the release location. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 8 e2374 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jan Medlock Katherine E Atkins David N Thomas Serap Aksoy Alison P Galvani Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this approach involves modification of the commensal symbiotic bacteria Sodalis to express trypanosome-resistance-conferring products. Modified Sodalis can then be driven into the tsetse population by cytoplasmic incompatibility (CI) from Wolbachia bacteria. To evaluate the effectiveness of this paratransgenic strategy in controlling African trypanosomiasis, we developed a three-species mathematical model of trypanosomiasis transmission among tsetse, humans, and animal reservoir hosts. Using empirical estimates of CI parameters, we found that paratransgenic tsetse have the potential to eliminate trypanosomiasis, provided that any extra mortality caused by Wolbachia colonization is low, that the paratransgene is effective at protecting against trypanosome transmission, and that the target tsetse species comprises a large majority of the tsetse population in the release location. |
format |
Article in Journal/Newspaper |
author |
Jan Medlock Katherine E Atkins David N Thomas Serap Aksoy Alison P Galvani |
author_facet |
Jan Medlock Katherine E Atkins David N Thomas Serap Aksoy Alison P Galvani |
author_sort |
Jan Medlock |
title |
Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. |
title_short |
Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. |
title_full |
Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. |
title_fullStr |
Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. |
title_full_unstemmed |
Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. |
title_sort |
evaluating paratransgenesis as a potential control strategy for african trypanosomiasis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002374 https://doaj.org/article/6c46add28d904516ab1c4e4087d00f9c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 8, p e2374 (2013) |
op_relation |
http://europepmc.org/articles/PMC3744416?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002374 https://doaj.org/article/6c46add28d904516ab1c4e4087d00f9c |
op_doi |
https://doi.org/10.1371/journal.pntd.0002374 |
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PLoS Neglected Tropical Diseases |
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7 |
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8 |
container_start_page |
e2374 |
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1766335809225490432 |