Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
In recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceará state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests we...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:6c3ce59d7ee64b43ae32a225636e579a 2023-05-15T15:03:17+02:00 Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus Ara Silva SM Morais MMM Marques DM Lima SCC Santos RR Almeida IGP Vieira MIF Guedes 2011-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992011000400007 https://doaj.org/article/6c3ce59d7ee64b43ae32a225636e579a EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400007 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000400007 1678-9199 https://doaj.org/article/6c3ce59d7ee64b43ae32a225636e579a Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 4, Pp 406-413 (2011) natural products phenols dengue antiviral agents Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2011 ftdoajarticles https://doi.org/10.1590/S1678-91992011000400007 2022-12-31T14:09:41Z In recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceará state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests were performed against type-2 dengue virus by the MTT method and standard cytopathic effect reduction assay in C6/36 cells. Cytotoxicity was also evaluated by MTT. The presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by HPLC analysis. Both Spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with IC50 of 362.68 µg/mL and 500 µg/mL, respectively. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 17 4 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
natural products phenols dengue antiviral agents Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
natural products phenols dengue antiviral agents Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Ara Silva SM Morais MMM Marques DM Lima SCC Santos RR Almeida IGP Vieira MIF Guedes Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus |
topic_facet |
natural products phenols dengue antiviral agents Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
In recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceará state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests were performed against type-2 dengue virus by the MTT method and standard cytopathic effect reduction assay in C6/36 cells. Cytotoxicity was also evaluated by MTT. The presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by HPLC analysis. Both Spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with IC50 of 362.68 µg/mL and 500 µg/mL, respectively. |
format |
Article in Journal/Newspaper |
author |
Ara Silva SM Morais MMM Marques DM Lima SCC Santos RR Almeida IGP Vieira MIF Guedes |
author_facet |
Ara Silva SM Morais MMM Marques DM Lima SCC Santos RR Almeida IGP Vieira MIF Guedes |
author_sort |
Ara Silva |
title |
Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus |
title_short |
Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus |
title_full |
Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus |
title_fullStr |
Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus |
title_full_unstemmed |
Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus |
title_sort |
antiviral activities of extracts and phenolic components of two spondias species against dengue virus |
publisher |
SciELO |
publishDate |
2011 |
url |
https://doi.org/10.1590/S1678-91992011000400007 https://doaj.org/article/6c3ce59d7ee64b43ae32a225636e579a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 4, Pp 406-413 (2011) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400007 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000400007 1678-9199 https://doaj.org/article/6c3ce59d7ee64b43ae32a225636e579a |
op_doi |
https://doi.org/10.1590/S1678-91992011000400007 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
17 |
container_issue |
4 |
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1766335151107735552 |