A meta-analysis of TLR4 and TLR9 SNPs implicated in severe malaria
Abstract Toll-like receptors (TLRs) are critical mediators of the inflammatory response to malarial infection, and gene polymorphisms affecting TLR function may be partially responsible for inter-individual variation in disease manifestation. However, there are inconsistencies in the associations of...
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ftdoajarticles:oai:doaj.org/article:6baee09fadca4bddbe7cf37648673b9c 2023-05-15T15:11:15+02:00 A meta-analysis of TLR4 and TLR9 SNPs implicated in severe malaria Gunanidhi Dhangadamajhi Avishek Kar Ronnaly Rout Prabin Dhangadamajhi https://doi.org/10.1590/0037-8682-0475-2016 https://doaj.org/article/6baee09fadca4bddbe7cf37648673b9c EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000200153&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0475-2016 https://doaj.org/article/6baee09fadca4bddbe7cf37648673b9c Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 2, Pp 153-160 Malaria Toll like receptors Meta-analysis Polymorphisms Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0475-2016 2022-12-30T23:17:38Z Abstract Toll-like receptors (TLRs) are critical mediators of the inflammatory response to malarial infection, and gene polymorphisms affecting TLR function may be partially responsible for inter-individual variation in disease manifestation. However, there are inconsistencies in the associations of common genetic variants of TLR4 (D299G) and TLR9 (T-1237C and T-1486C) with malaria outcome. A comprehensive search was conducted to identify relevant and independent Plasmodium falciparum-infected case-control studies, and meta-analysis including six studies for each SNP was performed to obtain more precise estimates of the pooled effects of these variants. The results showed significant associations of the -1486C allele with the risk of severe malaria in allele contrast (T vs. C, p = 0.004, OR = 1.26) and homozygous (TT vs. CC, p = 0.03, OR = 1.51) genetic models. There was no association between the D299G or T-1237C variants and uncomplicated or severe malaria using any of the genetic models tested. However, in stratified analysis, -1237C was associated with the risk of severe malaria in Indian adults (TT vs. TC, p = 0.06, OR = 2.13; TT vs. TC+CC, p <0.00001, OR = 2.65), suggesting that our results must be considered preliminary. The robustness of -1486C as a risk factor warrants investigation into its functionality in malaria pathogenesis. Further, the lack of an association with the T-1237C variant was weak, and future studies examining more detailed individual data from different ethnic groups are essential for confirmation of its genetic contribution to malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Indian Revista da Sociedade Brasileira de Medicina Tropical 50 2 153 160 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Toll like receptors Meta-analysis Polymorphisms Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Malaria Toll like receptors Meta-analysis Polymorphisms Arctic medicine. Tropical medicine RC955-962 Gunanidhi Dhangadamajhi Avishek Kar Ronnaly Rout Prabin Dhangadamajhi A meta-analysis of TLR4 and TLR9 SNPs implicated in severe malaria |
topic_facet |
Malaria Toll like receptors Meta-analysis Polymorphisms Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Toll-like receptors (TLRs) are critical mediators of the inflammatory response to malarial infection, and gene polymorphisms affecting TLR function may be partially responsible for inter-individual variation in disease manifestation. However, there are inconsistencies in the associations of common genetic variants of TLR4 (D299G) and TLR9 (T-1237C and T-1486C) with malaria outcome. A comprehensive search was conducted to identify relevant and independent Plasmodium falciparum-infected case-control studies, and meta-analysis including six studies for each SNP was performed to obtain more precise estimates of the pooled effects of these variants. The results showed significant associations of the -1486C allele with the risk of severe malaria in allele contrast (T vs. C, p = 0.004, OR = 1.26) and homozygous (TT vs. CC, p = 0.03, OR = 1.51) genetic models. There was no association between the D299G or T-1237C variants and uncomplicated or severe malaria using any of the genetic models tested. However, in stratified analysis, -1237C was associated with the risk of severe malaria in Indian adults (TT vs. TC, p = 0.06, OR = 2.13; TT vs. TC+CC, p <0.00001, OR = 2.65), suggesting that our results must be considered preliminary. The robustness of -1486C as a risk factor warrants investigation into its functionality in malaria pathogenesis. Further, the lack of an association with the T-1237C variant was weak, and future studies examining more detailed individual data from different ethnic groups are essential for confirmation of its genetic contribution to malaria. |
format |
Article in Journal/Newspaper |
author |
Gunanidhi Dhangadamajhi Avishek Kar Ronnaly Rout Prabin Dhangadamajhi |
author_facet |
Gunanidhi Dhangadamajhi Avishek Kar Ronnaly Rout Prabin Dhangadamajhi |
author_sort |
Gunanidhi Dhangadamajhi |
title |
A meta-analysis of TLR4 and TLR9 SNPs implicated in severe malaria |
title_short |
A meta-analysis of TLR4 and TLR9 SNPs implicated in severe malaria |
title_full |
A meta-analysis of TLR4 and TLR9 SNPs implicated in severe malaria |
title_fullStr |
A meta-analysis of TLR4 and TLR9 SNPs implicated in severe malaria |
title_full_unstemmed |
A meta-analysis of TLR4 and TLR9 SNPs implicated in severe malaria |
title_sort |
meta-analysis of tlr4 and tlr9 snps implicated in severe malaria |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0475-2016 https://doaj.org/article/6baee09fadca4bddbe7cf37648673b9c |
geographic |
Arctic Indian |
geographic_facet |
Arctic Indian |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 2, Pp 153-160 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000200153&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0475-2016 https://doaj.org/article/6baee09fadca4bddbe7cf37648673b9c |
op_doi |
https://doi.org/10.1590/0037-8682-0475-2016 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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50 |
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153 |
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160 |
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