MyD88 activation in cardiomyocytes contributes to the heart immune response to acute Trypanosoma cruzi infection with no effect on local parasite control.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Danni Yohani Santana, Rafael Moysés Salgado, Marina Fevereiro, Rogério Silva do Nascimento, Raissa Fonseca, Niels Olsen Saraiva Câmara, Sabrina Epiphanio, Cláudio Romero Farias Marinho, Maria Luiza Barreto-Chaves, Maria Regina D' Império-Lima, José M Álvarez
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2018
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; The ''Y''
• Online Access: https://doi.org/10.1371/journal.pntd.0006617; https://doaj.org/article/6b89d81dc8f84510916bbbb27095f04b

Cardiomyopathy is the most serious consequence of Chagas disease, a neglected human disorder caused by Trypanosoma cruzi infection. Because T. cruzi parasites invade cardiomyocytes, we sought to investigate whether these cells recognize the parasite in vivo by receptors signaling through the MyD88 a...