Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities
Heidi Tiller,1 Anne Husebekk,1 Maria Therese Ahlen,2 Tor B Stuge,1 Bjørn Skogen3 1Immunology Research Group, Faculty of Health Sciences, UiT, The Arctic University of Norway, 2Division of Diagnostic Services, Department of Laboratory Medicine, 3Department of Laboratory Medicine, Norwegian National U...
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ftdoajarticles:oai:doaj.org/article:6b684ec7033f4fd6a0b3fa40bacc2666 2023-05-15T17:39:22+02:00 Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities Tiller H Husebekk A Ahlen MT Stuge TB Skogen B 2017-04-01T00:00:00Z https://doaj.org/article/6b684ec7033f4fd6a0b3fa40bacc2666 EN eng Dove Medical Press https://www.dovepress.com/current-perspectives-on-fetal-and-neonatal-alloimmune-thrombocytopenia-peer-reviewed-article-IJWH https://doaj.org/toc/1179-1411 1179-1411 https://doaj.org/article/6b684ec7033f4fd6a0b3fa40bacc2666 International Journal of Women's Health, Vol Volume 9, Pp 223-234 (2017) Thrombocytopenia antibodies screening alloimmunization platelets Gynecology and obstetrics RG1-991 article 2017 ftdoajarticles 2022-12-31T14:55:41Z Heidi Tiller,1 Anne Husebekk,1 Maria Therese Ahlen,2 Tor B Stuge,1 Bjørn Skogen3 1Immunology Research Group, Faculty of Health Sciences, UiT, The Arctic University of Norway, 2Division of Diagnostic Services, Department of Laboratory Medicine, 3Department of Laboratory Medicine, Norwegian National Unit for Platelet Immunology, University Hospital of North Norway, Tromsø, Norway Abstract: Differences in platelet type between the fetus and the mother can lead to maternal immunization and destruction of the fetal platelets, a condition named fetal and neonatal alloimmune thrombocytopenia (FNAIT). FNAIT is reported to occur in ~1 per 1,000 live born neonates. The major risk is intracranial hemorrhage in the fetus or newborn, which is associated with severe neurological complications or death. Since no countries have yet implemented a screening program to detect pregnancies at risk, the diagnosis is typically established after the birth of a child with symptoms. Reports on broader clinical impact have increased clinical concern and awareness. Along with new treatment options for FNAIT, the debate around antenatal screening to detect pregnancies at risk of FNAIT has been revitalized. Keywords: antibodies, screening, alloimmunization, platelets, newborn, pregnancy Article in Journal/Newspaper North Norway Tromsø Arctic University of Norway UiT The Arctic University of Norway Directory of Open Access Journals: DOAJ Articles Arctic Norway Tromsø Bjørn ENVELOPE(12.585,12.585,66.082,66.082) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Thrombocytopenia antibodies screening alloimmunization platelets Gynecology and obstetrics RG1-991 |
spellingShingle |
Thrombocytopenia antibodies screening alloimmunization platelets Gynecology and obstetrics RG1-991 Tiller H Husebekk A Ahlen MT Stuge TB Skogen B Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities |
topic_facet |
Thrombocytopenia antibodies screening alloimmunization platelets Gynecology and obstetrics RG1-991 |
description |
Heidi Tiller,1 Anne Husebekk,1 Maria Therese Ahlen,2 Tor B Stuge,1 Bjørn Skogen3 1Immunology Research Group, Faculty of Health Sciences, UiT, The Arctic University of Norway, 2Division of Diagnostic Services, Department of Laboratory Medicine, 3Department of Laboratory Medicine, Norwegian National Unit for Platelet Immunology, University Hospital of North Norway, Tromsø, Norway Abstract: Differences in platelet type between the fetus and the mother can lead to maternal immunization and destruction of the fetal platelets, a condition named fetal and neonatal alloimmune thrombocytopenia (FNAIT). FNAIT is reported to occur in ~1 per 1,000 live born neonates. The major risk is intracranial hemorrhage in the fetus or newborn, which is associated with severe neurological complications or death. Since no countries have yet implemented a screening program to detect pregnancies at risk, the diagnosis is typically established after the birth of a child with symptoms. Reports on broader clinical impact have increased clinical concern and awareness. Along with new treatment options for FNAIT, the debate around antenatal screening to detect pregnancies at risk of FNAIT has been revitalized. Keywords: antibodies, screening, alloimmunization, platelets, newborn, pregnancy |
format |
Article in Journal/Newspaper |
author |
Tiller H Husebekk A Ahlen MT Stuge TB Skogen B |
author_facet |
Tiller H Husebekk A Ahlen MT Stuge TB Skogen B |
author_sort |
Tiller H |
title |
Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities |
title_short |
Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities |
title_full |
Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities |
title_fullStr |
Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities |
title_full_unstemmed |
Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities |
title_sort |
current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities |
publisher |
Dove Medical Press |
publishDate |
2017 |
url |
https://doaj.org/article/6b684ec7033f4fd6a0b3fa40bacc2666 |
long_lat |
ENVELOPE(12.585,12.585,66.082,66.082) |
geographic |
Arctic Norway Tromsø Bjørn |
geographic_facet |
Arctic Norway Tromsø Bjørn |
genre |
North Norway Tromsø Arctic University of Norway UiT The Arctic University of Norway |
genre_facet |
North Norway Tromsø Arctic University of Norway UiT The Arctic University of Norway |
op_source |
International Journal of Women's Health, Vol Volume 9, Pp 223-234 (2017) |
op_relation |
https://www.dovepress.com/current-perspectives-on-fetal-and-neonatal-alloimmune-thrombocytopenia-peer-reviewed-article-IJWH https://doaj.org/toc/1179-1411 1179-1411 https://doaj.org/article/6b684ec7033f4fd6a0b3fa40bacc2666 |
_version_ |
1766140129135558656 |