Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases.
Public-private partnerships (PPPs) for neglected tropical diseases (NTDs) are often studied as an organizational form that facilitates the management and control of the huge costs of drug research and development. Especially the later stages of drug development, including clinical trials, become ver...
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ftdoajarticles:oai:doaj.org/article:6b5172a183fb4f789fdf0ef7d5689648 2024-01-14T10:04:41+01:00 Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases. Zhongxuan Ma Kevin Augustijn Iwan De Esch Bart Bossink 2023-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011760 https://doaj.org/article/6b5172a183fb4f789fdf0ef7d5689648 EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011760&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011760 https://doaj.org/article/6b5172a183fb4f789fdf0ef7d5689648 PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011760 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011760 2023-12-17T01:44:39Z Public-private partnerships (PPPs) for neglected tropical diseases (NTDs) are often studied as an organizational form that facilitates the management and control of the huge costs of drug research and development. Especially the later stages of drug development, including clinical trials, become very expensive. This present study investigates whether and how the type of PPPs influences the initiation and duration of NTD clinical trials. Using the ClinicalTrials.gov database, a dataset of 1175 NTD clinical studies that started between 2000 and 2021 is analyzed based on affiliation information and project duration. For the NTD clinical trials that resulted from PPPs, the collaborating types were determined and analyzed, including the public sector-, private sector-, governmental sector-, and nongovernmental organization-led collaborations. The determinants for the discontinuation of all stopped clinical trials were categorized into scientific-, funding-, political-, and logistic dimensions. The results reveal that public sector-led PPPs were the most common collaborative types, and logistic and scientific issues were the most frequent determinants of stopped clinical trials. Trial registration: ClinicalTrials.gov. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 11 e0011760 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Zhongxuan Ma Kevin Augustijn Iwan De Esch Bart Bossink Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Public-private partnerships (PPPs) for neglected tropical diseases (NTDs) are often studied as an organizational form that facilitates the management and control of the huge costs of drug research and development. Especially the later stages of drug development, including clinical trials, become very expensive. This present study investigates whether and how the type of PPPs influences the initiation and duration of NTD clinical trials. Using the ClinicalTrials.gov database, a dataset of 1175 NTD clinical studies that started between 2000 and 2021 is analyzed based on affiliation information and project duration. For the NTD clinical trials that resulted from PPPs, the collaborating types were determined and analyzed, including the public sector-, private sector-, governmental sector-, and nongovernmental organization-led collaborations. The determinants for the discontinuation of all stopped clinical trials were categorized into scientific-, funding-, political-, and logistic dimensions. The results reveal that public sector-led PPPs were the most common collaborative types, and logistic and scientific issues were the most frequent determinants of stopped clinical trials. Trial registration: ClinicalTrials.gov. |
format |
Article in Journal/Newspaper |
author |
Zhongxuan Ma Kevin Augustijn Iwan De Esch Bart Bossink |
author_facet |
Zhongxuan Ma Kevin Augustijn Iwan De Esch Bart Bossink |
author_sort |
Zhongxuan Ma |
title |
Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases. |
title_short |
Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases. |
title_full |
Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases. |
title_fullStr |
Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases. |
title_full_unstemmed |
Public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases. |
title_sort |
public-private partnerships influencing the initiation and duration of clinical trials for neglected tropical diseases. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011760 https://doaj.org/article/6b5172a183fb4f789fdf0ef7d5689648 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011760 (2023) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011760&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011760 https://doaj.org/article/6b5172a183fb4f789fdf0ef7d5689648 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011760 |
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PLOS Neglected Tropical Diseases |
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17 |
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11 |
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e0011760 |
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