K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: a systematic review of prevalence and risk factors

• Published in: Malaria Journal
• Main Authors: Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere, Ekwaro Obuku
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2019
• Subjects: Artemisinin; K13-propeller gene polymorphism; Malaria; Africa; Plasmodium falciparum; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Prisma
• Online Access: https://doi.org/10.1186/s12936-019-2701-6; https://doaj.org/article/6b47e1317619404099c50cc439d0a719

Abstract Background Efficacy of artemisinin (ART) agents, a critical element of current malaria control efforts is threatened by emergence and spread of resistance. Mutations in pfkelch13 gene associated with ART-resistance evolved in Southeast Asia (SEA). k13 mutations whose role in ART-resistance...