Molecular genetic association of rs8099917 and rs1800795 polymorphisms in the progression of hepatitis Delta virus liver disease

• Published in: Journal of Venomous Animals and Toxins including Tropical Diseases
• Main Authors: Ana Maísa Passos-Silva, Eugênia de Castro e Silva, Lourdes Maria Pinheiro Borzacov, Adrhyan Araújo, Anita Sperandio Porto, Juan Miguel Villalobos Salcedo, Deusilene Vieira
• Format: Article in Journal/Newspaper
• Language: English
• Published: SciELO 2024
• Subjects: Polymorphisms; Chronic liver disease; Hepatitis Delta Virus; Arctic medicine. Tropical medicine; RC955-962; Toxicology. Poisons; RA1190-1270; Zoology; QL1-991; Arctic; Lambda
• Online Access: https://doi.org/10.1590/1678-9199-jvatitd-2023-0025; https://doaj.org/article/6ac7df2ccf1b4030bac0a7d12bc41651

Abstract Background: The relationship between viral infections and host factors holds high hopes for identifying the role of Interferon Lambda 3 (IFNL3) and Interleukin 6 (IL-6) polymorphisms in the development of Chronic Liver Disease (CLD) in patients infected with hepatitis Delta virus (HDV) in the Western Brazilian Amazon. Methods: Cross-sectional study conducted with a cohort of 40 chronic HDV patients, 27 with CLD and 13 without evident liver damage. Biological samples from the participants were analyzed using the polymerase chain reaction (PCR) technique, followed by sequencing by the automated Sanger method. Results: The rs8099917 T allele, from the IFNL3 gene, showed a higher frequency in both groups; however, it was not possible to establish an association with HDV infection [OR = 1.42 (0.42 - 4.75; p = 0.556 (95% CI). For IL-6, the rs1800795 G allele was superior to rs1800795 C. Analyzing both distributions in the studied groups, any association with HDV was absent (p > 0.05). Conclusion: The results suggest that the rs8099917 T/G (IFNL3) and rs1800795 G/C (IL-6) polymorphisms are not associated with the evolution of HDV in the studied population.