Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific.
The human malaria parasite Plasmodium vivax is more resistant to malaria control strategies than Plasmodium falciparum, and maintains high genetic diversity even when transmission is low. To investigate whether declining P. vivax transmission leads to increasing population structure that would facil...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0006146 https://doaj.org/article/6ac36d9013ad4fb1bc6e9f45d6ae2ea8 |
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ftdoajarticles:oai:doaj.org/article:6ac36d9013ad4fb1bc6e9f45d6ae2ea8 2023-05-15T15:07:05+02:00 Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. Andreea Waltmann Cristian Koepfli Natacha Tessier Stephan Karl Abebe Fola Andrew W Darcy Lyndes Wini G L Abby Harrison Céline Barnadas Charlie Jennison Harin Karunajeewa Sarah Boyd Maxine Whittaker James Kazura Melanie Bahlo Ivo Mueller Alyssa E Barry 2018-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006146 https://doaj.org/article/6ac36d9013ad4fb1bc6e9f45d6ae2ea8 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5802943?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006146 https://doaj.org/article/6ac36d9013ad4fb1bc6e9f45d6ae2ea8 PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006146 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006146 2022-12-31T03:53:58Z The human malaria parasite Plasmodium vivax is more resistant to malaria control strategies than Plasmodium falciparum, and maintains high genetic diversity even when transmission is low. To investigate whether declining P. vivax transmission leads to increasing population structure that would facilitate elimination, we genotyped samples from across the Southwest Pacific region, which experiences an eastward decline in malaria transmission, as well as samples from two time points at one site (Tetere, Solomon Islands) during intensified malaria control. Analysis of 887 P. vivax microsatellite haplotypes from hyperendemic Papua New Guinea (PNG, n = 443), meso-hyperendemic Solomon Islands (n = 420), and hypoendemic Vanuatu (n = 24) revealed increasing population structure and multilocus linkage disequilibrium yet a modest decline in diversity as transmission decreases over space and time. In Solomon Islands, which has had sustained control efforts for 20 years, and Vanuatu, which has experienced sustained low transmission for many years, significant population structure was observed at different spatial scales. We conclude that control efforts will eventually impact P. vivax population structure and with sustained pressure, populations may eventually fragment into a limited number of clustered foci that could be targeted for elimination. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific PLOS Neglected Tropical Diseases 12 1 e0006146 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Andreea Waltmann Cristian Koepfli Natacha Tessier Stephan Karl Abebe Fola Andrew W Darcy Lyndes Wini G L Abby Harrison Céline Barnadas Charlie Jennison Harin Karunajeewa Sarah Boyd Maxine Whittaker James Kazura Melanie Bahlo Ivo Mueller Alyssa E Barry Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The human malaria parasite Plasmodium vivax is more resistant to malaria control strategies than Plasmodium falciparum, and maintains high genetic diversity even when transmission is low. To investigate whether declining P. vivax transmission leads to increasing population structure that would facilitate elimination, we genotyped samples from across the Southwest Pacific region, which experiences an eastward decline in malaria transmission, as well as samples from two time points at one site (Tetere, Solomon Islands) during intensified malaria control. Analysis of 887 P. vivax microsatellite haplotypes from hyperendemic Papua New Guinea (PNG, n = 443), meso-hyperendemic Solomon Islands (n = 420), and hypoendemic Vanuatu (n = 24) revealed increasing population structure and multilocus linkage disequilibrium yet a modest decline in diversity as transmission decreases over space and time. In Solomon Islands, which has had sustained control efforts for 20 years, and Vanuatu, which has experienced sustained low transmission for many years, significant population structure was observed at different spatial scales. We conclude that control efforts will eventually impact P. vivax population structure and with sustained pressure, populations may eventually fragment into a limited number of clustered foci that could be targeted for elimination. |
format |
Article in Journal/Newspaper |
author |
Andreea Waltmann Cristian Koepfli Natacha Tessier Stephan Karl Abebe Fola Andrew W Darcy Lyndes Wini G L Abby Harrison Céline Barnadas Charlie Jennison Harin Karunajeewa Sarah Boyd Maxine Whittaker James Kazura Melanie Bahlo Ivo Mueller Alyssa E Barry |
author_facet |
Andreea Waltmann Cristian Koepfli Natacha Tessier Stephan Karl Abebe Fola Andrew W Darcy Lyndes Wini G L Abby Harrison Céline Barnadas Charlie Jennison Harin Karunajeewa Sarah Boyd Maxine Whittaker James Kazura Melanie Bahlo Ivo Mueller Alyssa E Barry |
author_sort |
Andreea Waltmann |
title |
Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. |
title_short |
Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. |
title_full |
Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. |
title_fullStr |
Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. |
title_full_unstemmed |
Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. |
title_sort |
increasingly inbred and fragmented populations of plasmodium vivax associated with the eastward decline in malaria transmission across the southwest pacific. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006146 https://doaj.org/article/6ac36d9013ad4fb1bc6e9f45d6ae2ea8 |
geographic |
Arctic Pacific |
geographic_facet |
Arctic Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006146 (2018) |
op_relation |
http://europepmc.org/articles/PMC5802943?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006146 https://doaj.org/article/6ac36d9013ad4fb1bc6e9f45d6ae2ea8 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006146 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
1 |
container_start_page |
e0006146 |
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1766338649502253056 |