Early-life obesity and adulthood colorectal cancer risk: a meta-analysis
Objective. This meta-analysis examines the relationship between early-life obesity and risk of colorectal cancer (CRC) in adulthood. Methods. A systematic search of Google Scholar, PubMed, and reference data was conducted. Fifteen relevant studies were identified and meta-analyzed, for men and women...
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ftdoajarticles:oai:doaj.org/article:6ac138e48e02491a9cd9000b8106a50c 2023-05-15T15:12:54+02:00 Early-life obesity and adulthood colorectal cancer risk: a meta-analysis Harrison Garcia Mingyang Song 2019-01-01T00:00:00Z https://doi.org/10.26633/RPSP.2019.3 https://doaj.org/article/6ac138e48e02491a9cd9000b8106a50c EN ES PT eng spa por Pan American Health Organization http://iris.paho.org/xmlui/handle/123456789/49674 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2019.3 https://doaj.org/article/6ac138e48e02491a9cd9000b8106a50c Revista Panamericana de Salud Pública, Vol 43, Pp 1-8 (2019) Colorectal neoplasms rectal neoplasms obesity body mass index meta-analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.26633/RPSP.2019.3 2022-12-31T13:09:02Z Objective. This meta-analysis examines the relationship between early-life obesity and risk of colorectal cancer (CRC) in adulthood. Methods. A systematic search of Google Scholar, PubMed, and reference data was conducted. Fifteen relevant studies were identified and meta-analyzed, for men and women separately. A random-effects model was used to compare the multivariable-adjusted relative risks (RR) of overall and subsite-specific CRC to the highest versus lowest categories of body mass index (BMI) in early life. Meta-regression was performed on factors that may have contributed to between-study heterogeneity. Results. High early-life BMI was associated with a 39% increased risk of CRC in adult men (RR = 1.39, 95%CI = 1.20 – 1.62, P < 0.0001) and a 19% increased risk of CRC in adult women (RR = 1.19, 95%CI = 1.06 – 1.35, P = 0.004). No statistically significant heterogeneity was identified in meta-regression according to tumor subsite (RR = 1.06, 95%CI = 0.97 – 1.17, RR = 1.08, 95%CI = 0.99 – 1.18 for male and female proximal colon cancer; RR = 1.51, 95%CI = 1.22 – 1.87, RR = 1.08, 95%CI = 0.98 – 1.19 for male and female distal colon cancer; and RR = 1.39, 95%CI = 1.1 – 1.77, RR = 1.51, 95%CI = 0.94 – 2.03 for male and female rectal cancer) or other factors, including age of BMI assessment, self-reported or measured BMI, and adjustment for smoking. Conclusions. The results suggest that high early-life BMI is associated with increased risk of CRC in adulthood. Further studies should investigate adult CRC risk in early-life obese individuals from non-Western countries and the underlying mechanisms by which early-life adiposity may influence CRC pathogenesis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista Panamericana de Salud Pública 43 1 8 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Colorectal neoplasms rectal neoplasms obesity body mass index meta-analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Colorectal neoplasms rectal neoplasms obesity body mass index meta-analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Harrison Garcia Mingyang Song Early-life obesity and adulthood colorectal cancer risk: a meta-analysis |
topic_facet |
Colorectal neoplasms rectal neoplasms obesity body mass index meta-analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Objective. This meta-analysis examines the relationship between early-life obesity and risk of colorectal cancer (CRC) in adulthood. Methods. A systematic search of Google Scholar, PubMed, and reference data was conducted. Fifteen relevant studies were identified and meta-analyzed, for men and women separately. A random-effects model was used to compare the multivariable-adjusted relative risks (RR) of overall and subsite-specific CRC to the highest versus lowest categories of body mass index (BMI) in early life. Meta-regression was performed on factors that may have contributed to between-study heterogeneity. Results. High early-life BMI was associated with a 39% increased risk of CRC in adult men (RR = 1.39, 95%CI = 1.20 – 1.62, P < 0.0001) and a 19% increased risk of CRC in adult women (RR = 1.19, 95%CI = 1.06 – 1.35, P = 0.004). No statistically significant heterogeneity was identified in meta-regression according to tumor subsite (RR = 1.06, 95%CI = 0.97 – 1.17, RR = 1.08, 95%CI = 0.99 – 1.18 for male and female proximal colon cancer; RR = 1.51, 95%CI = 1.22 – 1.87, RR = 1.08, 95%CI = 0.98 – 1.19 for male and female distal colon cancer; and RR = 1.39, 95%CI = 1.1 – 1.77, RR = 1.51, 95%CI = 0.94 – 2.03 for male and female rectal cancer) or other factors, including age of BMI assessment, self-reported or measured BMI, and adjustment for smoking. Conclusions. The results suggest that high early-life BMI is associated with increased risk of CRC in adulthood. Further studies should investigate adult CRC risk in early-life obese individuals from non-Western countries and the underlying mechanisms by which early-life adiposity may influence CRC pathogenesis. |
format |
Article in Journal/Newspaper |
author |
Harrison Garcia Mingyang Song |
author_facet |
Harrison Garcia Mingyang Song |
author_sort |
Harrison Garcia |
title |
Early-life obesity and adulthood colorectal cancer risk: a meta-analysis |
title_short |
Early-life obesity and adulthood colorectal cancer risk: a meta-analysis |
title_full |
Early-life obesity and adulthood colorectal cancer risk: a meta-analysis |
title_fullStr |
Early-life obesity and adulthood colorectal cancer risk: a meta-analysis |
title_full_unstemmed |
Early-life obesity and adulthood colorectal cancer risk: a meta-analysis |
title_sort |
early-life obesity and adulthood colorectal cancer risk: a meta-analysis |
publisher |
Pan American Health Organization |
publishDate |
2019 |
url |
https://doi.org/10.26633/RPSP.2019.3 https://doaj.org/article/6ac138e48e02491a9cd9000b8106a50c |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 43, Pp 1-8 (2019) |
op_relation |
http://iris.paho.org/xmlui/handle/123456789/49674 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2019.3 https://doaj.org/article/6ac138e48e02491a9cd9000b8106a50c |
op_doi |
https://doi.org/10.26633/RPSP.2019.3 |
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Revista Panamericana de Salud Pública |
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43 |
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1 |
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8 |
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1766343528577761280 |