Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations.
Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the pr...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0007859 https://doaj.org/article/6abf07e1a57f42f29f31d7336730e2c8 |
id |
ftdoajarticles:oai:doaj.org/article:6abf07e1a57f42f29f31d7336730e2c8 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:6abf07e1a57f42f29f31d7336730e2c8 2023-05-15T15:11:27+02:00 Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations. Mariana Strauss Marialbert Acosta-Herrera Alexia Alcaraz Desiré Casares-Marfil Pau Bosch-Nicolau María Silvina Lo Presti Israel Molina Clara Isabel González Chagas Genetics CYTED Network Javier Martín 2019-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007859 https://doaj.org/article/6abf07e1a57f42f29f31d7336730e2c8 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007859 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007859 https://doaj.org/article/6abf07e1a57f42f29f31d7336730e2c8 PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007859 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007859 2022-12-31T04:33:59Z Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentina PLOS Neglected Tropical Diseases 13 11 e0007859 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Mariana Strauss Marialbert Acosta-Herrera Alexia Alcaraz Desiré Casares-Marfil Pau Bosch-Nicolau María Silvina Lo Presti Israel Molina Clara Isabel González Chagas Genetics CYTED Network Javier Martín Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied. |
format |
Article in Journal/Newspaper |
author |
Mariana Strauss Marialbert Acosta-Herrera Alexia Alcaraz Desiré Casares-Marfil Pau Bosch-Nicolau María Silvina Lo Presti Israel Molina Clara Isabel González Chagas Genetics CYTED Network Javier Martín |
author_facet |
Mariana Strauss Marialbert Acosta-Herrera Alexia Alcaraz Desiré Casares-Marfil Pau Bosch-Nicolau María Silvina Lo Presti Israel Molina Clara Isabel González Chagas Genetics CYTED Network Javier Martín |
author_sort |
Mariana Strauss |
title |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations. |
title_short |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations. |
title_full |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations. |
title_fullStr |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations. |
title_full_unstemmed |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations. |
title_sort |
association of il18 genetic polymorphisms with chagas disease in latin american populations. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007859 https://doaj.org/article/6abf07e1a57f42f29f31d7336730e2c8 |
geographic |
Arctic Argentina |
geographic_facet |
Arctic Argentina |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007859 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007859 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007859 https://doaj.org/article/6abf07e1a57f42f29f31d7336730e2c8 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007859 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
11 |
container_start_page |
e0007859 |
_version_ |
1766342293230452736 |