Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study.
Background Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nond...
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ftdoajarticles:oai:doaj.org/article:6ab4c30db0a64183be50fbe64ae60af8 2023-05-15T18:34:18+02:00 Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. Svein Ivar Bekkelund 2023-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0281239 https://doaj.org/article/6ab4c30db0a64183be50fbe64ae60af8 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pone.0281239 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0281239 https://doaj.org/article/6ab4c30db0a64183be50fbe64ae60af8 PLoS ONE, Vol 18, Iss 2, p e0281239 (2023) Medicine R Science Q article 2023 ftdoajarticles https://doi.org/10.1371/journal.pone.0281239 2023-02-12T01:30:39Z Background Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population. Methods Associations between CK and the outcome variable HbA1C (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA1C (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. Results Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA1C (%) in the "high CK" group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the "normal CK" group, P <0.001. CK increased significantly and linearly with higher levels of HbA1C (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA1C (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA1C (%). Conclusion These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Norway Tromsø PLOS ONE 18 2 e0281239 |
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Medicine R Science Q Svein Ivar Bekkelund Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. |
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Medicine R Science Q |
description |
Background Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population. Methods Associations between CK and the outcome variable HbA1C (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA1C (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. Results Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA1C (%) in the "high CK" group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the "normal CK" group, P <0.001. CK increased significantly and linearly with higher levels of HbA1C (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA1C (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA1C (%). Conclusion These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population. |
format |
Article in Journal/Newspaper |
author |
Svein Ivar Bekkelund |
author_facet |
Svein Ivar Bekkelund |
author_sort |
Svein Ivar Bekkelund |
title |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. |
title_short |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. |
title_full |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. |
title_fullStr |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. |
title_full_unstemmed |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study. |
title_sort |
creatine kinase is associated with glycated haemoglobin in a nondiabetic population. the tromsø study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pone.0281239 https://doaj.org/article/6ab4c30db0a64183be50fbe64ae60af8 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
PLoS ONE, Vol 18, Iss 2, p e0281239 (2023) |
op_relation |
https://doi.org/10.1371/journal.pone.0281239 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0281239 https://doaj.org/article/6ab4c30db0a64183be50fbe64ae60af8 |
op_doi |
https://doi.org/10.1371/journal.pone.0281239 |
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PLOS ONE |
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18 |
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2 |
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e0281239 |
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