Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study.
Background Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nond...
| Published in: | PLOS ONE |
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| Main Author: | |
| Format: | Article in Journal/Newspaper |
| Language: | English |
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Public Library of Science (PLoS)
2023
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| Subjects: | |
| Online Access: | https://doi.org/10.1371/journal.pone.0281239 https://doaj.org/article/6ab4c30db0a64183be50fbe64ae60af8 |
| Summary: | Background Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population. Methods Associations between CK and the outcome variable HbA1C (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA1C (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. Results Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA1C (%) in the "high CK" group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the "normal CK" group, P <0.001. CK increased significantly and linearly with higher levels of HbA1C (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA1C (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA1C (%). Conclusion These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population. |
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