Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.
Background Targeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little evidence to suggest...
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ftdoajarticles:oai:doaj.org/article:6a745354fac048e69f32bee0153e1f90 2023-05-15T15:16:06+02:00 Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd 2021-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009562 https://doaj.org/article/6a745354fac048e69f32bee0153e1f90 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009562 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009562 https://doaj.org/article/6a745354fac048e69f32bee0153e1f90 PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009562 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009562 2023-02-26T01:32:20Z Background Targeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little evidence to suggest how precisely targeted or how recent cases need to be, to mount an effective response. The growing interest in the development of prophylactic and therapeutic drugs for dengue has also given new relevance for CATI strategies to interrupt transmission or deliver early treatment. Methods/principal findings Here we develop a patch-based mathematical model of spatial dengue spread and fit it to spatiotemporal datasets from Singapore. Simulations from this model suggest CATI strategies could be effective, particularly if used in lower density areas. To maximise effectiveness, increasing the size of the radius around an index case should be prioritised even if it results in delays in the intervention being applied. This is partially because large intervention radii ensure individuals receive multiple and regular rounds of drug dosing or vector control, and thus boost overall coverage. Given equivalent efficacy, CATIs using prophylactic drugs are predicted to be more effective than adult mosquito-killing vector control methods and may even offer the possibility of interrupting individual chains of transmission if rapidly deployed. CATI strategies quickly lose their effectiveness if baseline transmission increases or case detection rates fall. Conclusions/significance These results suggest CATI strategies can play an important role in dengue control but are likely to be most relevant for low transmission areas where high coverage of other non-reactive interventions already exists. Controlled field trials are needed to assess the field efficacy and practical constraints of large operational CATI strategies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 8 e0009562 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Targeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little evidence to suggest how precisely targeted or how recent cases need to be, to mount an effective response. The growing interest in the development of prophylactic and therapeutic drugs for dengue has also given new relevance for CATI strategies to interrupt transmission or deliver early treatment. Methods/principal findings Here we develop a patch-based mathematical model of spatial dengue spread and fit it to spatiotemporal datasets from Singapore. Simulations from this model suggest CATI strategies could be effective, particularly if used in lower density areas. To maximise effectiveness, increasing the size of the radius around an index case should be prioritised even if it results in delays in the intervention being applied. This is partially because large intervention radii ensure individuals receive multiple and regular rounds of drug dosing or vector control, and thus boost overall coverage. Given equivalent efficacy, CATIs using prophylactic drugs are predicted to be more effective than adult mosquito-killing vector control methods and may even offer the possibility of interrupting individual chains of transmission if rapidly deployed. CATI strategies quickly lose their effectiveness if baseline transmission increases or case detection rates fall. Conclusions/significance These results suggest CATI strategies can play an important role in dengue control but are likely to be most relevant for low transmission areas where high coverage of other non-reactive interventions already exists. Controlled field trials are needed to assess the field efficacy and practical constraints of large operational CATI strategies. |
format |
Article in Journal/Newspaper |
author |
Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd |
author_facet |
Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd |
author_sort |
Oliver J Brady |
title |
Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
title_short |
Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
title_full |
Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
title_fullStr |
Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
title_full_unstemmed |
Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
title_sort |
case-area targeted interventions (cati) for reactive dengue control: modelling effectiveness of vector control and prophylactic drugs in singapore. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009562 https://doaj.org/article/6a745354fac048e69f32bee0153e1f90 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009562 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009562 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009562 https://doaj.org/article/6a745354fac048e69f32bee0153e1f90 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009562 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
8 |
container_start_page |
e0009562 |
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1766346407134887936 |