Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour
Abstract Background Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many...
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ftdoajarticles:oai:doaj.org/article:6a54fddbe0f244958aa250c547830a75 2023-05-15T15:11:25+02:00 Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour Veronika Kuznetsova Alexander Tyakht Lyudmila Akhmadishina Vera Odintsova Natalia Klimenko Elena Kostryukova Maria Vakhitova Tatyana Grigoryeva Sergey Malanin Vsevolod Vladimirtsev Raisa Nikitina Viktor Volok Vladimir Osakovskiy Tatiana Sivtseva Fyodor Platonov Dmitry Alexeev Galina Karganova 2020-11-01T00:00:00Z https://doi.org/10.1186/s13023-020-01612-4 https://doaj.org/article/6a54fddbe0f244958aa250c547830a75 EN eng BMC http://link.springer.com/article/10.1186/s13023-020-01612-4 https://doaj.org/toc/1750-1172 doi:10.1186/s13023-020-01612-4 1750-1172 https://doaj.org/article/6a54fddbe0f244958aa250c547830a75 Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-11 (2020) Gut microbiome Viliuisk encephalomyelitis Yakuts 16S rRNA sequencing Methanobrevibacter Microbiome-gut-brain axis Medicine R article 2020 ftdoajarticles https://doi.org/10.1186/s13023-020-01612-4 2022-12-31T02:00:36Z Abstract Background Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many hypotheses have been proposed regarding its etiology, including infectious agents, genetics, environmental factors, and immunopathology. Each of these hypotheses has been supported to some extent by epidemiological and experimental data. Nevertheless, none of them has been decisively proven. Gut microbiome is one of the factors that might be involved in VE pathogenesis. Results Here we performed a pilot survey of the stool microbiomes of Yakut subjects with VE (n = 6) and without VE (n = 11). 16S rRNA sequencing showed that in comparison with the control group, the Yakuts with VE had increased proportions of Methanobrevibacter and Christensenella, which are reported to be linked to body mass index, metabolism, dietary habits and potentially to neurodegenerative disorders. The identified associations suggest that the microbiome may be involved in VE. Overall, the Yakut microbiome was quite specific in comparison with other populations, such as metropolitan Russians and native inhabitants of the Canadian Arctic. Conclusions Describing the gut microbiome of indigenous human populations will help to elucidate the impact of dietary and environmental factors on microbial community structure and identify risks linked to the lifestyles of such groups as well as endemic diseases. Article in Journal/Newspaper Arctic Yakut Yakuts Siberia Directory of Open Access Journals: DOAJ Articles Arctic Orphanet Journal of Rare Diseases 15 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Gut microbiome Viliuisk encephalomyelitis Yakuts 16S rRNA sequencing Methanobrevibacter Microbiome-gut-brain axis Medicine R |
spellingShingle |
Gut microbiome Viliuisk encephalomyelitis Yakuts 16S rRNA sequencing Methanobrevibacter Microbiome-gut-brain axis Medicine R Veronika Kuznetsova Alexander Tyakht Lyudmila Akhmadishina Vera Odintsova Natalia Klimenko Elena Kostryukova Maria Vakhitova Tatyana Grigoryeva Sergey Malanin Vsevolod Vladimirtsev Raisa Nikitina Viktor Volok Vladimir Osakovskiy Tatiana Sivtseva Fyodor Platonov Dmitry Alexeev Galina Karganova Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
topic_facet |
Gut microbiome Viliuisk encephalomyelitis Yakuts 16S rRNA sequencing Methanobrevibacter Microbiome-gut-brain axis Medicine R |
description |
Abstract Background Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many hypotheses have been proposed regarding its etiology, including infectious agents, genetics, environmental factors, and immunopathology. Each of these hypotheses has been supported to some extent by epidemiological and experimental data. Nevertheless, none of them has been decisively proven. Gut microbiome is one of the factors that might be involved in VE pathogenesis. Results Here we performed a pilot survey of the stool microbiomes of Yakut subjects with VE (n = 6) and without VE (n = 11). 16S rRNA sequencing showed that in comparison with the control group, the Yakuts with VE had increased proportions of Methanobrevibacter and Christensenella, which are reported to be linked to body mass index, metabolism, dietary habits and potentially to neurodegenerative disorders. The identified associations suggest that the microbiome may be involved in VE. Overall, the Yakut microbiome was quite specific in comparison with other populations, such as metropolitan Russians and native inhabitants of the Canadian Arctic. Conclusions Describing the gut microbiome of indigenous human populations will help to elucidate the impact of dietary and environmental factors on microbial community structure and identify risks linked to the lifestyles of such groups as well as endemic diseases. |
format |
Article in Journal/Newspaper |
author |
Veronika Kuznetsova Alexander Tyakht Lyudmila Akhmadishina Vera Odintsova Natalia Klimenko Elena Kostryukova Maria Vakhitova Tatyana Grigoryeva Sergey Malanin Vsevolod Vladimirtsev Raisa Nikitina Viktor Volok Vladimir Osakovskiy Tatiana Sivtseva Fyodor Platonov Dmitry Alexeev Galina Karganova |
author_facet |
Veronika Kuznetsova Alexander Tyakht Lyudmila Akhmadishina Vera Odintsova Natalia Klimenko Elena Kostryukova Maria Vakhitova Tatyana Grigoryeva Sergey Malanin Vsevolod Vladimirtsev Raisa Nikitina Viktor Volok Vladimir Osakovskiy Tatiana Sivtseva Fyodor Platonov Dmitry Alexeev Galina Karganova |
author_sort |
Veronika Kuznetsova |
title |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_short |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_full |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_fullStr |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_full_unstemmed |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_sort |
gut microbiome signature of viliuisk encephalomyelitis in yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s13023-020-01612-4 https://doaj.org/article/6a54fddbe0f244958aa250c547830a75 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Yakut Yakuts Siberia |
genre_facet |
Arctic Yakut Yakuts Siberia |
op_source |
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-11 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s13023-020-01612-4 https://doaj.org/toc/1750-1172 doi:10.1186/s13023-020-01612-4 1750-1172 https://doaj.org/article/6a54fddbe0f244958aa250c547830a75 |
op_doi |
https://doi.org/10.1186/s13023-020-01612-4 |
container_title |
Orphanet Journal of Rare Diseases |
container_volume |
15 |
container_issue |
1 |
_version_ |
1766342271714721792 |