Open source drug discovery in practice: a case study.
BACKGROUND: Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical in...
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ftdoajarticles:oai:doaj.org/article:6a53313391394ae8811ff0eeef03d513 2023-05-15T15:16:05+02:00 Open source drug discovery in practice: a case study. Christine Årdal John-Arne Røttingen 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001827 https://doaj.org/article/6a53313391394ae8811ff0eeef03d513 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3447952?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001827 1935-2727 1935-2735 https://doaj.org/article/6a53313391394ae8811ff0eeef03d513 PLoS Neglected Tropical Diseases, Vol 6, Iss 9, p e1827 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001827 2022-12-30T23:31:35Z BACKGROUND: Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. METHODOLOGY/PRINCIPAL FINDINGS: A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. CONCLUSIONS/SIGNIFICANCE: Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality research at low cost. The critical success ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Indian PLoS Neglected Tropical Diseases 6 9 e1827 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Christine Årdal John-Arne Røttingen Open source drug discovery in practice: a case study. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Open source drug discovery offers potential for developing new and inexpensive drugs to combat diseases that disproportionally affect the poor. The concept borrows two principle aspects from open source computing (i.e., collaboration and open access) and applies them to pharmaceutical innovation. By opening a project to external contributors, its research capacity may increase significantly. To date there are only a handful of open source R&D projects focusing on neglected diseases. We wanted to learn from these first movers, their successes and failures, in order to generate a better understanding of how a much-discussed theoretical concept works in practice and may be implemented. METHODOLOGY/PRINCIPAL FINDINGS: A descriptive case study was performed, evaluating two specific R&D projects focused on neglected diseases. CSIR Team India Consortium's Open Source Drug Discovery project (CSIR OSDD) and The Synaptic Leap's Schistosomiasis project (TSLS). Data were gathered from four sources: interviews of participating members (n = 14), a survey of potential members (n = 61), an analysis of the websites and a literature review. Both cases have made significant achievements; however, they have done so in very different ways. CSIR OSDD encourages international collaboration, but its process facilitates contributions from mostly Indian researchers and students. Its processes are formal with each task being reviewed by a mentor (almost always offline) before a result is made public. TSLS, on the other hand, has attracted contributors internationally, albeit significantly fewer than CSIR OSDD. Both have obtained funding used to pay for access to facilities, physical resources and, at times, labor costs. TSLS releases its results into the public domain, whereas CSIR OSDD asserts ownership over its results. CONCLUSIONS/SIGNIFICANCE: Technically TSLS is an open source project, whereas CSIR OSDD is a crowdsourced project. However, both have enabled high quality research at low cost. The critical success ... |
format |
Article in Journal/Newspaper |
author |
Christine Årdal John-Arne Røttingen |
author_facet |
Christine Årdal John-Arne Røttingen |
author_sort |
Christine Årdal |
title |
Open source drug discovery in practice: a case study. |
title_short |
Open source drug discovery in practice: a case study. |
title_full |
Open source drug discovery in practice: a case study. |
title_fullStr |
Open source drug discovery in practice: a case study. |
title_full_unstemmed |
Open source drug discovery in practice: a case study. |
title_sort |
open source drug discovery in practice: a case study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001827 https://doaj.org/article/6a53313391394ae8811ff0eeef03d513 |
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Arctic Indian |
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Arctic Indian |
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Arctic |
genre_facet |
Arctic |
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PLoS Neglected Tropical Diseases, Vol 6, Iss 9, p e1827 (2012) |
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http://europepmc.org/articles/PMC3447952?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001827 1935-2727 1935-2735 https://doaj.org/article/6a53313391394ae8811ff0eeef03d513 |
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https://doi.org/10.1371/journal.pntd.0001827 |
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PLoS Neglected Tropical Diseases |
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