Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers.
The aim of this study was to identify potential mucin genes in the Atlantic salmon genome and evaluate tissue-specific distribution and transcriptional regulation in response to aquaculture-relevant stress conditions in post-smolts. Seven secreted gel-forming mucin genes were identified based on sev...
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ftdoajarticles:oai:doaj.org/article:6a431ef6404e41328c64c1f56328b1bc 2023-05-15T15:31:08+02:00 Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers. Lene Rydal Sveen Fabian Thomas Grammes Elisabeth Ytteborg Harald Takle Sven Martin Jørgensen 2017-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0189103 https://doaj.org/article/6a431ef6404e41328c64c1f56328b1bc EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5728529?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0189103 https://doaj.org/article/6a431ef6404e41328c64c1f56328b1bc PLoS ONE, Vol 12, Iss 12, p e0189103 (2017) Medicine R Science Q article 2017 ftdoajarticles https://doi.org/10.1371/journal.pone.0189103 2022-12-30T22:13:32Z The aim of this study was to identify potential mucin genes in the Atlantic salmon genome and evaluate tissue-specific distribution and transcriptional regulation in response to aquaculture-relevant stress conditions in post-smolts. Seven secreted gel-forming mucin genes were identified based on several layers of evidence; annotation, transcription, phylogeny and domain structure. Two genes were annotated as muc2 and five genes as muc5. The muc2 genes were predominantly transcribed in the intestinal region while the different genes in the muc5 family were mainly transcribed in either skin, gill or pyloric caeca. In order to investigate transcriptional regulation of mucins during stress conditions, two controlled experiments were conducted. In the first experiment, handling stress induced mucin transcription in the gill, while transcription decreased in the skin and intestine. In the second experiment, long term intensive rearing conditions (fish biomass ~125 kg/m3) interrupted by additional confinement led to increased transcription of mucin genes in the skin at one, seven and fourteen days post-confinement. Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles PLOS ONE 12 12 e0189103 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Lene Rydal Sveen Fabian Thomas Grammes Elisabeth Ytteborg Harald Takle Sven Martin Jørgensen Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers. |
topic_facet |
Medicine R Science Q |
description |
The aim of this study was to identify potential mucin genes in the Atlantic salmon genome and evaluate tissue-specific distribution and transcriptional regulation in response to aquaculture-relevant stress conditions in post-smolts. Seven secreted gel-forming mucin genes were identified based on several layers of evidence; annotation, transcription, phylogeny and domain structure. Two genes were annotated as muc2 and five genes as muc5. The muc2 genes were predominantly transcribed in the intestinal region while the different genes in the muc5 family were mainly transcribed in either skin, gill or pyloric caeca. In order to investigate transcriptional regulation of mucins during stress conditions, two controlled experiments were conducted. In the first experiment, handling stress induced mucin transcription in the gill, while transcription decreased in the skin and intestine. In the second experiment, long term intensive rearing conditions (fish biomass ~125 kg/m3) interrupted by additional confinement led to increased transcription of mucin genes in the skin at one, seven and fourteen days post-confinement. |
format |
Article in Journal/Newspaper |
author |
Lene Rydal Sveen Fabian Thomas Grammes Elisabeth Ytteborg Harald Takle Sven Martin Jørgensen |
author_facet |
Lene Rydal Sveen Fabian Thomas Grammes Elisabeth Ytteborg Harald Takle Sven Martin Jørgensen |
author_sort |
Lene Rydal Sveen |
title |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers. |
title_short |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers. |
title_full |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers. |
title_fullStr |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers. |
title_full_unstemmed |
Genome-wide analysis of Atlantic salmon (Salmo salar) mucin genes and their role as biomarkers. |
title_sort |
genome-wide analysis of atlantic salmon (salmo salar) mucin genes and their role as biomarkers. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pone.0189103 https://doaj.org/article/6a431ef6404e41328c64c1f56328b1bc |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
PLoS ONE, Vol 12, Iss 12, p e0189103 (2017) |
op_relation |
http://europepmc.org/articles/PMC5728529?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0189103 https://doaj.org/article/6a431ef6404e41328c64c1f56328b1bc |
op_doi |
https://doi.org/10.1371/journal.pone.0189103 |
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PLOS ONE |
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12 |
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12 |
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e0189103 |
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1766361633987231744 |