Examining the relationship between urogenital schistosomiasis and HIV infection.
Urogenital schistosomiasis, caused by infection with Schistosoma haematobium, is widespread and causes substantial morbidity on the African continent. The infection has been suggested as an unrecognized risk factor for incident HIV infection. Current guidelines recommend preventive chemotherapy, usi...
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ftdoajarticles:oai:doaj.org/article:6a0e67b68b3b4d9a89b115f1efdfcbfe 2023-05-15T15:11:44+02:00 Examining the relationship between urogenital schistosomiasis and HIV infection. Pamela Sabina Mbabazi Olivia Andan Daniel W Fitzgerald Lester Chitsulo Dirk Engels Jennifer A Downs 2011-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001396 https://doaj.org/article/6a0e67b68b3b4d9a89b115f1efdfcbfe EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3232194?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001396 https://doaj.org/article/6a0e67b68b3b4d9a89b115f1efdfcbfe PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1396 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001396 2022-12-30T20:49:43Z Urogenital schistosomiasis, caused by infection with Schistosoma haematobium, is widespread and causes substantial morbidity on the African continent. The infection has been suggested as an unrecognized risk factor for incident HIV infection. Current guidelines recommend preventive chemotherapy, using praziquantel as a public health tool, to avert morbidity due to schistosomiasis. In individuals of reproductive age, urogenital schistosomiasis remains highly prevalent and, likely, underdiagnosed. This comprehensive literature review was undertaken to examine the evidence for a cause-effect relationship between urogenital schistosomiasis and HIV/AIDS. The review aims to support discussions of urogenital schistosomiasis as a neglected yet urgent public health challenge.We conducted a systematic search of the literature including online databases, clinical guidelines, and current medical textbooks. We describe plausible local and systemic mechanisms by which Schistosoma haematobium infection could increase the risk of HIV acquisition in both women and men. We also detail the effects of S. haematobium infection on the progression and transmissibility of HIV in co-infected individuals. We briefly summarize available evidence on the immunomodulatory effects of chronic schistosomiasis and the implications this might have for populations at high risk of both schistosomiasis and HIV.Studies support the hypothesis that urogenital schistosomiasis in women and men constitutes a significant risk factor for HIV acquisition due both to local genital tract and global immunological effects. In those who become HIV-infected, schistosomal co-infection may accelerate HIV disease progression and facilitate viral transmission to sexual partners. Establishing effective prevention strategies using praziquantel, including better definition of treatment age, duration, and frequency of treatment for urogenital schistosomiasis, is an important public health priority. Our findings call attention to this pressing yet neglected public health ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 12 e1396 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Pamela Sabina Mbabazi Olivia Andan Daniel W Fitzgerald Lester Chitsulo Dirk Engels Jennifer A Downs Examining the relationship between urogenital schistosomiasis and HIV infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Urogenital schistosomiasis, caused by infection with Schistosoma haematobium, is widespread and causes substantial morbidity on the African continent. The infection has been suggested as an unrecognized risk factor for incident HIV infection. Current guidelines recommend preventive chemotherapy, using praziquantel as a public health tool, to avert morbidity due to schistosomiasis. In individuals of reproductive age, urogenital schistosomiasis remains highly prevalent and, likely, underdiagnosed. This comprehensive literature review was undertaken to examine the evidence for a cause-effect relationship between urogenital schistosomiasis and HIV/AIDS. The review aims to support discussions of urogenital schistosomiasis as a neglected yet urgent public health challenge.We conducted a systematic search of the literature including online databases, clinical guidelines, and current medical textbooks. We describe plausible local and systemic mechanisms by which Schistosoma haematobium infection could increase the risk of HIV acquisition in both women and men. We also detail the effects of S. haematobium infection on the progression and transmissibility of HIV in co-infected individuals. We briefly summarize available evidence on the immunomodulatory effects of chronic schistosomiasis and the implications this might have for populations at high risk of both schistosomiasis and HIV.Studies support the hypothesis that urogenital schistosomiasis in women and men constitutes a significant risk factor for HIV acquisition due both to local genital tract and global immunological effects. In those who become HIV-infected, schistosomal co-infection may accelerate HIV disease progression and facilitate viral transmission to sexual partners. Establishing effective prevention strategies using praziquantel, including better definition of treatment age, duration, and frequency of treatment for urogenital schistosomiasis, is an important public health priority. Our findings call attention to this pressing yet neglected public health ... |
format |
Article in Journal/Newspaper |
author |
Pamela Sabina Mbabazi Olivia Andan Daniel W Fitzgerald Lester Chitsulo Dirk Engels Jennifer A Downs |
author_facet |
Pamela Sabina Mbabazi Olivia Andan Daniel W Fitzgerald Lester Chitsulo Dirk Engels Jennifer A Downs |
author_sort |
Pamela Sabina Mbabazi |
title |
Examining the relationship between urogenital schistosomiasis and HIV infection. |
title_short |
Examining the relationship between urogenital schistosomiasis and HIV infection. |
title_full |
Examining the relationship between urogenital schistosomiasis and HIV infection. |
title_fullStr |
Examining the relationship between urogenital schistosomiasis and HIV infection. |
title_full_unstemmed |
Examining the relationship between urogenital schistosomiasis and HIV infection. |
title_sort |
examining the relationship between urogenital schistosomiasis and hiv infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001396 https://doaj.org/article/6a0e67b68b3b4d9a89b115f1efdfcbfe |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
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PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1396 (2011) |
op_relation |
http://europepmc.org/articles/PMC3232194?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001396 https://doaj.org/article/6a0e67b68b3b4d9a89b115f1efdfcbfe |
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https://doi.org/10.1371/journal.pntd.0001396 |
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PLoS Neglected Tropical Diseases |
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