Nitric Oxide Production and Regulation in the Teleost Cardiovascular System
Nitric Oxide (NO) is a free radical with numerous critical signaling roles in vertebrate physiology. Similar to mammals, in the teleost system the generation of sufficient amounts of NO is critical for the physiological function of the cardiovascular system. At the same time, NO amounts are strictly...
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MDPI AG
2022
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ftdoajarticles:oai:doaj.org/article:69f5fb0b860a4890b93fc1839f30fffe 2023-10-01T03:50:31+02:00 Nitric Oxide Production and Regulation in the Teleost Cardiovascular System Daniela Giordano Cinzia Verde Paola Corti 2022-05-01T00:00:00Z https://doi.org/10.3390/antiox11050957 https://doaj.org/article/69f5fb0b860a4890b93fc1839f30fffe EN eng MDPI AG https://www.mdpi.com/2076-3921/11/5/957 https://doaj.org/toc/2076-3921 doi:10.3390/antiox11050957 2076-3921 https://doaj.org/article/69f5fb0b860a4890b93fc1839f30fffe Antioxidants, Vol 11, Iss 957, p 957 (2022) nitric oxide synthase Antarctic fish hemoglobin myoglobin neuroglobin cytoglobin Therapeutics. Pharmacology RM1-950 article 2022 ftdoajarticles https://doi.org/10.3390/antiox11050957 2023-09-03T00:40:04Z Nitric Oxide (NO) is a free radical with numerous critical signaling roles in vertebrate physiology. Similar to mammals, in the teleost system the generation of sufficient amounts of NO is critical for the physiological function of the cardiovascular system. At the same time, NO amounts are strictly controlled and kept within basal levels to protect cells from NO toxicity. Changes in oxygen tension highly influence NO bioavailability and can modulate the mechanisms involved in maintaining the NO balance. While NO production and signaling appears to have general similarities with mammalian systems, the wide range of environmental adaptations made by fish, particularly with regards to differing oxygen availabilities in aquatic habitats, creates a foundation for a variety of in vivo models characterized by different implications of NO production and signaling. In this review, we present the biology of NO in the teleost cardiovascular system and summarize the mechanisms of NO production and signaling with a special emphasis on the role of globin proteins in NO metabolism. Article in Journal/Newspaper Antarc* Antarctic Directory of Open Access Journals: DOAJ Articles Antarctic Antioxidants 11 5 957 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
nitric oxide synthase Antarctic fish hemoglobin myoglobin neuroglobin cytoglobin Therapeutics. Pharmacology RM1-950 |
spellingShingle |
nitric oxide synthase Antarctic fish hemoglobin myoglobin neuroglobin cytoglobin Therapeutics. Pharmacology RM1-950 Daniela Giordano Cinzia Verde Paola Corti Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
topic_facet |
nitric oxide synthase Antarctic fish hemoglobin myoglobin neuroglobin cytoglobin Therapeutics. Pharmacology RM1-950 |
description |
Nitric Oxide (NO) is a free radical with numerous critical signaling roles in vertebrate physiology. Similar to mammals, in the teleost system the generation of sufficient amounts of NO is critical for the physiological function of the cardiovascular system. At the same time, NO amounts are strictly controlled and kept within basal levels to protect cells from NO toxicity. Changes in oxygen tension highly influence NO bioavailability and can modulate the mechanisms involved in maintaining the NO balance. While NO production and signaling appears to have general similarities with mammalian systems, the wide range of environmental adaptations made by fish, particularly with regards to differing oxygen availabilities in aquatic habitats, creates a foundation for a variety of in vivo models characterized by different implications of NO production and signaling. In this review, we present the biology of NO in the teleost cardiovascular system and summarize the mechanisms of NO production and signaling with a special emphasis on the role of globin proteins in NO metabolism. |
format |
Article in Journal/Newspaper |
author |
Daniela Giordano Cinzia Verde Paola Corti |
author_facet |
Daniela Giordano Cinzia Verde Paola Corti |
author_sort |
Daniela Giordano |
title |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_short |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_full |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_fullStr |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_full_unstemmed |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_sort |
nitric oxide production and regulation in the teleost cardiovascular system |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/antiox11050957 https://doaj.org/article/69f5fb0b860a4890b93fc1839f30fffe |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Antioxidants, Vol 11, Iss 957, p 957 (2022) |
op_relation |
https://www.mdpi.com/2076-3921/11/5/957 https://doaj.org/toc/2076-3921 doi:10.3390/antiox11050957 2076-3921 https://doaj.org/article/69f5fb0b860a4890b93fc1839f30fffe |
op_doi |
https://doi.org/10.3390/antiox11050957 |
container_title |
Antioxidants |
container_volume |
11 |
container_issue |
5 |
container_start_page |
957 |
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1778524236694945792 |