Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal
Abstract Background There are no data on the long term use of an artemisinin combination treatment in moderate or high transmission areas of Africa. Methods and findings Artesunate plus amodiaquine (AS+AQ) was used to treat slide-proven Plasmodium falciparum -infected patients of all ages in the Ous...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2007
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-6-150 https://doaj.org/article/69ea899a669745aab1281007c334493c |
id |
ftdoajarticles:oai:doaj.org/article:69ea899a669745aab1281007c334493c |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:69ea899a669745aab1281007c334493c 2023-05-15T15:10:15+02:00 Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal Vaillant Michel Gaye Oumar Agnamey Patrice Brasseur Philippe Taylor Walter RJ Olliaro Piero L 2007-11-01T00:00:00Z https://doi.org/10.1186/1475-2875-6-150 https://doaj.org/article/69ea899a669745aab1281007c334493c EN eng BMC http://www.malariajournal.com/content/6/1/150 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-150 1475-2875 https://doaj.org/article/69ea899a669745aab1281007c334493c Malaria Journal, Vol 6, Iss 1, p 150 (2007) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1186/1475-2875-6-150 2022-12-31T14:00:31Z Abstract Background There are no data on the long term use of an artemisinin combination treatment in moderate or high transmission areas of Africa. Methods and findings Artesunate plus amodiaquine (AS+AQ) was used to treat slide-proven Plasmodium falciparum -infected patients of all ages in the Oussouye district, Casamance, Senegal, over a period of six years (2000 to 2005). Efficacy, by Kaplan Meier survival analysis (n = 966), and safety (adverse event rates, n = 752) were determined over 28 days. A weight-based dosing regimen was used for the loose tablets during 2000–2003 (n = 731) and a commercially available co-blister was used during 2004–2005 (n = 235). Annual crude (non PCR corrected) rates remained stable over the study period [range 88.5–96.7%; overall 94.6 (95% CI 92.9–95.9)]. Nine co-blister treated patients (0.9%) withdrew because of drug-related adverse events; seven had gastrointestinal complaints of whom two were hospitalized for vomiting. By Day 28, the mean total bilirubin (n = 72), AST (n = 94) and ALT (n = 95) values decreased. Three patients had Day 28 AST/ALT values > 40 < 200 IU/L. Changes in white cell counts were unremarkable (n = 87). Conclusion AS+AQ in combination was highly efficacious and well-tolerated in this area and justifies the decision to use it as first line treatment. Long-term monitoring of safety and efficacy should continue. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) Malaria Journal 6 1 150 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Vaillant Michel Gaye Oumar Agnamey Patrice Brasseur Philippe Taylor Walter RJ Olliaro Piero L Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background There are no data on the long term use of an artemisinin combination treatment in moderate or high transmission areas of Africa. Methods and findings Artesunate plus amodiaquine (AS+AQ) was used to treat slide-proven Plasmodium falciparum -infected patients of all ages in the Oussouye district, Casamance, Senegal, over a period of six years (2000 to 2005). Efficacy, by Kaplan Meier survival analysis (n = 966), and safety (adverse event rates, n = 752) were determined over 28 days. A weight-based dosing regimen was used for the loose tablets during 2000–2003 (n = 731) and a commercially available co-blister was used during 2004–2005 (n = 235). Annual crude (non PCR corrected) rates remained stable over the study period [range 88.5–96.7%; overall 94.6 (95% CI 92.9–95.9)]. Nine co-blister treated patients (0.9%) withdrew because of drug-related adverse events; seven had gastrointestinal complaints of whom two were hospitalized for vomiting. By Day 28, the mean total bilirubin (n = 72), AST (n = 94) and ALT (n = 95) values decreased. Three patients had Day 28 AST/ALT values > 40 < 200 IU/L. Changes in white cell counts were unremarkable (n = 87). Conclusion AS+AQ in combination was highly efficacious and well-tolerated in this area and justifies the decision to use it as first line treatment. Long-term monitoring of safety and efficacy should continue. |
format |
Article in Journal/Newspaper |
author |
Vaillant Michel Gaye Oumar Agnamey Patrice Brasseur Philippe Taylor Walter RJ Olliaro Piero L |
author_facet |
Vaillant Michel Gaye Oumar Agnamey Patrice Brasseur Philippe Taylor Walter RJ Olliaro Piero L |
author_sort |
Vaillant Michel |
title |
Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal |
title_short |
Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal |
title_full |
Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal |
title_fullStr |
Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal |
title_full_unstemmed |
Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal |
title_sort |
efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in casamance, southern sénégal |
publisher |
BMC |
publishDate |
2007 |
url |
https://doi.org/10.1186/1475-2875-6-150 https://doaj.org/article/69ea899a669745aab1281007c334493c |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) |
geographic |
Arctic Meier |
geographic_facet |
Arctic Meier |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 6, Iss 1, p 150 (2007) |
op_relation |
http://www.malariajournal.com/content/6/1/150 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-150 1475-2875 https://doaj.org/article/69ea899a669745aab1281007c334493c |
op_doi |
https://doi.org/10.1186/1475-2875-6-150 |
container_title |
Malaria Journal |
container_volume |
6 |
container_issue |
1 |
container_start_page |
150 |
_version_ |
1766341298248220672 |