Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws.
BACKGROUND:Community mass treatment with 30 mg/kg azithromycin is central to the new WHO strategy for eradicating yaws. Both yaws and trachoma--which is earmarked for elimination by 2020 using a strategy that includes mass treatment with 20 mg/kg azithromycin--are endemic in the Pacific, raising the...
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ftdoajarticles:oai:doaj.org/article:69b292f307b84adf9467c9c59c05ee23 2023-05-15T15:13:54+02:00 Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. Michael Marks Ventis Vahi Oliver Sokana Kai-Hua Chi Elliot Puiahi Georgina Kilua Allan Pillay Tenneth Dalipanda Christian Bottomley Anthony W Solomon David C Mabey 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003988 https://doaj.org/article/69b292f307b84adf9467c9c59c05ee23 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4524711?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003988 https://doaj.org/article/69b292f307b84adf9467c9c59c05ee23 PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003988 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003988 2022-12-31T08:30:42Z BACKGROUND:Community mass treatment with 30 mg/kg azithromycin is central to the new WHO strategy for eradicating yaws. Both yaws and trachoma--which is earmarked for elimination by 2020 using a strategy that includes mass treatment with 20 mg/kg azithromycin--are endemic in the Pacific, raising the possibility of an integrated approach to disease control. Community mass treatment with azithromycin for trachoma elimination was conducted in the Solomon Islands in 2014. METHODS:We conducted a study to assess the impact of mass treatment with 20 mg/kg azithromycin on yaws. We examined children aged 5-14 years and took blood and lesion samples for yaws diagnosis. RESULTS:We recruited 897 children, 6 months after mass treatment. There were no cases of active yaws. Serological evidence of current infection was found in 3.6% (95% CI= 2.5-5.0%). This differed significantly between individuals who had and had not received azithromycin (2.8% vs 6.5%, p=0.015); the prevalence of positive serology in 5-14 year-olds had been 21.7% (95% CI=14.6%-30.9%) 6 months prior to mass treatment. Not receiving azithromycin was associated with an odds of 3.9 for infection (p=0.001). National figures showed a 57% reduction in reported cases of yaws following mass treatment. DISCUSSION:Following a single round of treatment we did not identify any cases of active yaws in a previously endemic population. We found a significant reduction in latent infection. Our data support expansion of the WHO eradication strategy and suggest an integrated approach to the control of yaws and trachoma in the Pacific may be viable. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific PLOS Neglected Tropical Diseases 9 8 e0003988 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Michael Marks Ventis Vahi Oliver Sokana Kai-Hua Chi Elliot Puiahi Georgina Kilua Allan Pillay Tenneth Dalipanda Christian Bottomley Anthony W Solomon David C Mabey Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Community mass treatment with 30 mg/kg azithromycin is central to the new WHO strategy for eradicating yaws. Both yaws and trachoma--which is earmarked for elimination by 2020 using a strategy that includes mass treatment with 20 mg/kg azithromycin--are endemic in the Pacific, raising the possibility of an integrated approach to disease control. Community mass treatment with azithromycin for trachoma elimination was conducted in the Solomon Islands in 2014. METHODS:We conducted a study to assess the impact of mass treatment with 20 mg/kg azithromycin on yaws. We examined children aged 5-14 years and took blood and lesion samples for yaws diagnosis. RESULTS:We recruited 897 children, 6 months after mass treatment. There were no cases of active yaws. Serological evidence of current infection was found in 3.6% (95% CI= 2.5-5.0%). This differed significantly between individuals who had and had not received azithromycin (2.8% vs 6.5%, p=0.015); the prevalence of positive serology in 5-14 year-olds had been 21.7% (95% CI=14.6%-30.9%) 6 months prior to mass treatment. Not receiving azithromycin was associated with an odds of 3.9 for infection (p=0.001). National figures showed a 57% reduction in reported cases of yaws following mass treatment. DISCUSSION:Following a single round of treatment we did not identify any cases of active yaws in a previously endemic population. We found a significant reduction in latent infection. Our data support expansion of the WHO eradication strategy and suggest an integrated approach to the control of yaws and trachoma in the Pacific may be viable. |
format |
Article in Journal/Newspaper |
author |
Michael Marks Ventis Vahi Oliver Sokana Kai-Hua Chi Elliot Puiahi Georgina Kilua Allan Pillay Tenneth Dalipanda Christian Bottomley Anthony W Solomon David C Mabey |
author_facet |
Michael Marks Ventis Vahi Oliver Sokana Kai-Hua Chi Elliot Puiahi Georgina Kilua Allan Pillay Tenneth Dalipanda Christian Bottomley Anthony W Solomon David C Mabey |
author_sort |
Michael Marks |
title |
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. |
title_short |
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. |
title_full |
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. |
title_fullStr |
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. |
title_full_unstemmed |
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. |
title_sort |
impact of community mass treatment with azithromycin for trachoma elimination on the prevalence of yaws. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003988 https://doaj.org/article/69b292f307b84adf9467c9c59c05ee23 |
geographic |
Arctic Pacific |
geographic_facet |
Arctic Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003988 (2015) |
op_relation |
http://europepmc.org/articles/PMC4524711?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003988 https://doaj.org/article/69b292f307b84adf9467c9c59c05ee23 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003988 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
8 |
container_start_page |
e0003988 |
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1766344419852681216 |