Therapeutic efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium vivax malaria in Seacha area, Arbaminch Zuria District, South West Ethiopia
Abstract Background Declining efficacy of chloroquine against Plasmodium vivax malaria has been documented in Ethiopia. Thus, there is a need to assess the efficacy of alternative schizontocidal anti-malarials such as dihydroartemisinin–piperaquine (DHA–PPQ) in P. vivax malaria-infected patients. Th...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2022
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-022-04380-7 https://doaj.org/article/699e1c4584214151a6a4c0f966c44638 |
id |
ftdoajarticles:oai:doaj.org/article:699e1c4584214151a6a4c0f966c44638 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:699e1c4584214151a6a4c0f966c44638 2023-05-15T15:15:50+02:00 Therapeutic efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium vivax malaria in Seacha area, Arbaminch Zuria District, South West Ethiopia Hussein Mohammed Heven Sime Henok Hailgiorgis Kale Gubae Mebrahtom Haile Hiwot Solomon Kebede Etana Samuel Girma Worku Bekele Melkie Chernet Getachew Tollera Geremew Tasew Bokretsion Gidey Robert J. Commons Ashenafi Assefa 2022-11-01T00:00:00Z https://doi.org/10.1186/s12936-022-04380-7 https://doaj.org/article/699e1c4584214151a6a4c0f966c44638 EN eng BMC https://doi.org/10.1186/s12936-022-04380-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04380-7 1475-2875 https://doaj.org/article/699e1c4584214151a6a4c0f966c44638 Malaria Journal, Vol 21, Iss 1, Pp 1-8 (2022) Chloroquine Dihydro-artemisinin–piperaquine Efficacy Ethiopia P. vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2022 ftdoajarticles https://doi.org/10.1186/s12936-022-04380-7 2022-12-30T22:35:29Z Abstract Background Declining efficacy of chloroquine against Plasmodium vivax malaria has been documented in Ethiopia. Thus, there is a need to assess the efficacy of alternative schizontocidal anti-malarials such as dihydroartemisinin–piperaquine (DHA–PPQ) in P. vivax malaria-infected patients. This study was conducted to evaluate the therapeutic efficacy of DHA–PPQ drug in South West Ethiopia. Methods This is a single-arm, prospective therapeutic efficacy study in patients with uncomplicated P. vivax malaria. The study was conducted from May 2021 to August 2021, based on the standard World Health Organization study protocol for surveillance of anti-malarial therapeutic efficacy. The study endpoint was adequate clinical and parasitological response on day 42. Results A total of 86 patients with uncomplicated vivax malaria were enrolled. Of these, 79 patients completed the scheduled follow up; all showing adequate clinical and parasitological responses to day 42, with a successful cure rate of 100% (95% CI 96–100). Parasitaemias were cleared rapidly (86% by day 1 and 100% by day 3), as were clinical symptoms (100% by day 1). Gametocyte carriage decreased from 44% on Day 0 to 1% on day 1 and 0% on Day 2. Mean haemoglobin concentrations increased between day 0 (mean 12.2 g/dL) and day 42 (mean 13.3 g/dL). Treatment was well tolerated and no severe adverse events were observed. Conclusion In summary, treatment with DHA–PPQ demonstrated excellent efficacy for uncomplicated P. vivax, with no recurrences to day 42, and no safety concerns. This treatment, which is also effective against P. falciparum, appears to be an ideal alternative for P. vivax as part of the malaria elimination programme. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 21 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chloroquine Dihydro-artemisinin–piperaquine Efficacy Ethiopia P. vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Chloroquine Dihydro-artemisinin–piperaquine Efficacy Ethiopia P. vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Hussein Mohammed Heven Sime Henok Hailgiorgis Kale Gubae Mebrahtom Haile Hiwot Solomon Kebede Etana Samuel Girma Worku Bekele Melkie Chernet Getachew Tollera Geremew Tasew Bokretsion Gidey Robert J. Commons Ashenafi Assefa Therapeutic efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium vivax malaria in Seacha area, Arbaminch Zuria District, South West Ethiopia |
topic_facet |
Chloroquine Dihydro-artemisinin–piperaquine Efficacy Ethiopia P. vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Declining efficacy of chloroquine against Plasmodium vivax malaria has been documented in Ethiopia. Thus, there is a need to assess the efficacy of alternative schizontocidal anti-malarials such as dihydroartemisinin–piperaquine (DHA–PPQ) in P. vivax malaria-infected patients. This study was conducted to evaluate the therapeutic efficacy of DHA–PPQ drug in South West Ethiopia. Methods This is a single-arm, prospective therapeutic efficacy study in patients with uncomplicated P. vivax malaria. The study was conducted from May 2021 to August 2021, based on the standard World Health Organization study protocol for surveillance of anti-malarial therapeutic efficacy. The study endpoint was adequate clinical and parasitological response on day 42. Results A total of 86 patients with uncomplicated vivax malaria were enrolled. Of these, 79 patients completed the scheduled follow up; all showing adequate clinical and parasitological responses to day 42, with a successful cure rate of 100% (95% CI 96–100). Parasitaemias were cleared rapidly (86% by day 1 and 100% by day 3), as were clinical symptoms (100% by day 1). Gametocyte carriage decreased from 44% on Day 0 to 1% on day 1 and 0% on Day 2. Mean haemoglobin concentrations increased between day 0 (mean 12.2 g/dL) and day 42 (mean 13.3 g/dL). Treatment was well tolerated and no severe adverse events were observed. Conclusion In summary, treatment with DHA–PPQ demonstrated excellent efficacy for uncomplicated P. vivax, with no recurrences to day 42, and no safety concerns. This treatment, which is also effective against P. falciparum, appears to be an ideal alternative for P. vivax as part of the malaria elimination programme. |
format |
Article in Journal/Newspaper |
author |
Hussein Mohammed Heven Sime Henok Hailgiorgis Kale Gubae Mebrahtom Haile Hiwot Solomon Kebede Etana Samuel Girma Worku Bekele Melkie Chernet Getachew Tollera Geremew Tasew Bokretsion Gidey Robert J. Commons Ashenafi Assefa |
author_facet |
Hussein Mohammed Heven Sime Henok Hailgiorgis Kale Gubae Mebrahtom Haile Hiwot Solomon Kebede Etana Samuel Girma Worku Bekele Melkie Chernet Getachew Tollera Geremew Tasew Bokretsion Gidey Robert J. Commons Ashenafi Assefa |
author_sort |
Hussein Mohammed |
title |
Therapeutic efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium vivax malaria in Seacha area, Arbaminch Zuria District, South West Ethiopia |
title_short |
Therapeutic efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium vivax malaria in Seacha area, Arbaminch Zuria District, South West Ethiopia |
title_full |
Therapeutic efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium vivax malaria in Seacha area, Arbaminch Zuria District, South West Ethiopia |
title_fullStr |
Therapeutic efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium vivax malaria in Seacha area, Arbaminch Zuria District, South West Ethiopia |
title_full_unstemmed |
Therapeutic efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium vivax malaria in Seacha area, Arbaminch Zuria District, South West Ethiopia |
title_sort |
therapeutic efficacy of dihydroartemisinin–piperaquine for the treatment of uncomplicated plasmodium vivax malaria in seacha area, arbaminch zuria district, south west ethiopia |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s12936-022-04380-7 https://doaj.org/article/699e1c4584214151a6a4c0f966c44638 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 21, Iss 1, Pp 1-8 (2022) |
op_relation |
https://doi.org/10.1186/s12936-022-04380-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04380-7 1475-2875 https://doaj.org/article/699e1c4584214151a6a4c0f966c44638 |
op_doi |
https://doi.org/10.1186/s12936-022-04380-7 |
container_title |
Malaria Journal |
container_volume |
21 |
container_issue |
1 |
_version_ |
1766346173762764800 |