Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking
Abstract Background The success of insecticide treated bed nets (ITNs) for malaria vector control in Africa relies on the behaviour of various species of Anopheles. Previous research has described mosquito behavioural alterations resulting from widespread ITN coverage, which could result in a decrea...
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ftdoajarticles:oai:doaj.org/article:6945d099a1bd4a7b9d61432fbf625776 2023-06-11T04:10:01+02:00 Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking Katherine Gleave Amy Guy Frank Mechan Mischa Emery Annabel Murphy Vitaly Voloshin Catherine E. Towers David Towers Hilary Ranson Geraldine M. Foster Philip J. McCall 2023-04-01T00:00:00Z https://doi.org/10.1186/s12936-023-04548-9 https://doaj.org/article/6945d099a1bd4a7b9d61432fbf625776 EN eng BMC https://doi.org/10.1186/s12936-023-04548-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04548-9 1475-2875 https://doaj.org/article/6945d099a1bd4a7b9d61432fbf625776 Malaria Journal, Vol 22, Iss 1, Pp 1-16 (2023) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-023-04548-9 2023-05-07T00:36:06Z Abstract Background The success of insecticide treated bed nets (ITNs) for malaria vector control in Africa relies on the behaviour of various species of Anopheles. Previous research has described mosquito behavioural alterations resulting from widespread ITN coverage, which could result in a decrease in net efficacy. Here, behaviours were compared including timings of net contact, willingness to refeed and longevity post-exposure to two next-generation nets, PermaNet® 3.0 (P3 net) and Interceptor® G2 (IG2 net) in comparison with a standard pyrethroid-only net (Olyset Net™ (OL net)) and an untreated net. Methods Susceptible and resistant Anopheles gambiae mosquitoes were exposed to the nets with a human volunteer host in a room-scale assay. Mosquito movements were tracked for 2 h using an infrared video system, collecting flight trajectory, spatial position and net contact data. Post-assay, mosquitoes were monitored for a range of sublethal insecticide effects. Results Mosquito net contact was focused predominantly on the roof for all four bed nets. A steep decay in activity was observed for both susceptible strains when P3 net and OL net were present and with IG2 net for one of the two susceptible strains. Total mosquito activity was higher around untreated nets than ITNs. There was no difference in total activity, the number, or duration, of net contact, between any mosquito strain, with similar behaviours recorded in susceptible and resistant strains at all ITNs. OL net, P3 net and IG2 net all killed over 90% of susceptible mosquitoes 24 h after exposure, but this effect was not seen with resistant mosquitoes where mortality ranged from 16 to 72%. All treated nets reduced the willingness of resistant strains to re-feed when offered blood 1-h post-exposure, with a more pronounced effect seen with P3 net and OL net than IG2 net. Conclusion These are the first results to provide an in-depth description of the behaviour of susceptible and resistant Anopheles gambiae strains around next-generation bed nets using a ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 22 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Katherine Gleave Amy Guy Frank Mechan Mischa Emery Annabel Murphy Vitaly Voloshin Catherine E. Towers David Towers Hilary Ranson Geraldine M. Foster Philip J. McCall Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The success of insecticide treated bed nets (ITNs) for malaria vector control in Africa relies on the behaviour of various species of Anopheles. Previous research has described mosquito behavioural alterations resulting from widespread ITN coverage, which could result in a decrease in net efficacy. Here, behaviours were compared including timings of net contact, willingness to refeed and longevity post-exposure to two next-generation nets, PermaNet® 3.0 (P3 net) and Interceptor® G2 (IG2 net) in comparison with a standard pyrethroid-only net (Olyset Net™ (OL net)) and an untreated net. Methods Susceptible and resistant Anopheles gambiae mosquitoes were exposed to the nets with a human volunteer host in a room-scale assay. Mosquito movements were tracked for 2 h using an infrared video system, collecting flight trajectory, spatial position and net contact data. Post-assay, mosquitoes were monitored for a range of sublethal insecticide effects. Results Mosquito net contact was focused predominantly on the roof for all four bed nets. A steep decay in activity was observed for both susceptible strains when P3 net and OL net were present and with IG2 net for one of the two susceptible strains. Total mosquito activity was higher around untreated nets than ITNs. There was no difference in total activity, the number, or duration, of net contact, between any mosquito strain, with similar behaviours recorded in susceptible and resistant strains at all ITNs. OL net, P3 net and IG2 net all killed over 90% of susceptible mosquitoes 24 h after exposure, but this effect was not seen with resistant mosquitoes where mortality ranged from 16 to 72%. All treated nets reduced the willingness of resistant strains to re-feed when offered blood 1-h post-exposure, with a more pronounced effect seen with P3 net and OL net than IG2 net. Conclusion These are the first results to provide an in-depth description of the behaviour of susceptible and resistant Anopheles gambiae strains around next-generation bed nets using a ... |
format |
Article in Journal/Newspaper |
author |
Katherine Gleave Amy Guy Frank Mechan Mischa Emery Annabel Murphy Vitaly Voloshin Catherine E. Towers David Towers Hilary Ranson Geraldine M. Foster Philip J. McCall |
author_facet |
Katherine Gleave Amy Guy Frank Mechan Mischa Emery Annabel Murphy Vitaly Voloshin Catherine E. Towers David Towers Hilary Ranson Geraldine M. Foster Philip J. McCall |
author_sort |
Katherine Gleave |
title |
Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking |
title_short |
Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking |
title_full |
Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking |
title_fullStr |
Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking |
title_full_unstemmed |
Impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant Anopheles gambiae determined by room-scale infrared video tracking |
title_sort |
impacts of dual active-ingredient bed nets on the behavioural responses of pyrethroid resistant anopheles gambiae determined by room-scale infrared video tracking |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-023-04548-9 https://doaj.org/article/6945d099a1bd4a7b9d61432fbf625776 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-16 (2023) |
op_relation |
https://doi.org/10.1186/s12936-023-04548-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04548-9 1475-2875 https://doaj.org/article/6945d099a1bd4a7b9d61432fbf625776 |
op_doi |
https://doi.org/10.1186/s12936-023-04548-9 |
container_title |
Malaria Journal |
container_volume |
22 |
container_issue |
1 |
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1768384087239688192 |