Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance
Introduction: Arthropod-borne viruses (arboviruses) cause morbidity and mortality in humans and domestic animals worldwide. The percentage of population immunity or susceptibility to these viruses in Ecuador is unknown. Objectives: To investigate the proportion of Ecuadorian populations with IgG ant...
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ftdoajarticles:oai:doaj.org/article:692efe20e23f491baca33cf5194a21b5 2023-05-15T15:09:58+02:00 Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance Ernesto Gutiérrez-Vera Leandro Patiño Martha Castillo-Segovia Víctor Mora-Valencia Julio Montesdeoca-Agurto Mary Regato-Arrata 2021-06-01T00:00:00Z https://doi.org/10.7705/biomedica.5623 https://doaj.org/article/692efe20e23f491baca33cf5194a21b5 EN ES eng spa Instituto Nacional de Salud https://revistabiomedica.org/index.php/biomedica/article/view/5623 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.5623 https://doaj.org/article/692efe20e23f491baca33cf5194a21b5 Biomédica: revista del Instituto Nacional de Salud, Vol 41, Iss 2, Pp 247-259 (2021) arbovirus yellow fever virus west nile virus dengue virus encephalitis virus venezuelan equine eastern equine Medicine R Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.7705/biomedica.5623 2022-12-31T02:11:17Z Introduction: Arthropod-borne viruses (arboviruses) cause morbidity and mortality in humans and domestic animals worldwide. The percentage of population immunity or susceptibility to these viruses in Ecuador is unknown. Objectives: To investigate the proportion of Ecuadorian populations with IgG antibodies (Abs) (past exposure/immunity) and IgM Abs (current exposure) against flaviviruses and alphaviruses and to study the activity of these viruses in Ecuador. Materials and methods: During 2009-2011, we conducted a serosurvey for selected arboviruses in humans (n=1,842), equines (n=149), and sentinel hamsters (n=84) at two coastal locations and one in the Amazon basin (Eastern Ecuador) using enzyme-linked immunosorbent assay and hemagglutination inhibition test. Results: From 20.63% to 63.61% of humans showed IgG-antibodies for the flaviviruses: Dengue virus (DENV), yellow fever virus (YFV) Saint Louis encephalitis virus, and West Nile virus (WNV); from 4.67% to 8.63% showed IgG-Abs for the alphaviruses: Venezuelan equine encephalitis virus, eastern equine encephalitis virus, and western equine encephalitis virus. IgM-Abs were found for DENV and WNV. Equines and hamsters showed antibodies to alphaviruses in all locations; two hamsters seroconverted to YFV in the Amazonia. Conclusions: The results show a YFV vaccination history and suggest the activity of arboviruses not included in the current surveillance scheme. Enhanced arbovirus and mosquito surveillance, as well as continued YFV vaccination and evaluation of its coverage/effectiveness, are recommended. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 41 2 247 259 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish |
topic |
arbovirus yellow fever virus west nile virus dengue virus encephalitis virus venezuelan equine eastern equine Medicine R Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
arbovirus yellow fever virus west nile virus dengue virus encephalitis virus venezuelan equine eastern equine Medicine R Arctic medicine. Tropical medicine RC955-962 Ernesto Gutiérrez-Vera Leandro Patiño Martha Castillo-Segovia Víctor Mora-Valencia Julio Montesdeoca-Agurto Mary Regato-Arrata Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance |
topic_facet |
arbovirus yellow fever virus west nile virus dengue virus encephalitis virus venezuelan equine eastern equine Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction: Arthropod-borne viruses (arboviruses) cause morbidity and mortality in humans and domestic animals worldwide. The percentage of population immunity or susceptibility to these viruses in Ecuador is unknown. Objectives: To investigate the proportion of Ecuadorian populations with IgG antibodies (Abs) (past exposure/immunity) and IgM Abs (current exposure) against flaviviruses and alphaviruses and to study the activity of these viruses in Ecuador. Materials and methods: During 2009-2011, we conducted a serosurvey for selected arboviruses in humans (n=1,842), equines (n=149), and sentinel hamsters (n=84) at two coastal locations and one in the Amazon basin (Eastern Ecuador) using enzyme-linked immunosorbent assay and hemagglutination inhibition test. Results: From 20.63% to 63.61% of humans showed IgG-antibodies for the flaviviruses: Dengue virus (DENV), yellow fever virus (YFV) Saint Louis encephalitis virus, and West Nile virus (WNV); from 4.67% to 8.63% showed IgG-Abs for the alphaviruses: Venezuelan equine encephalitis virus, eastern equine encephalitis virus, and western equine encephalitis virus. IgM-Abs were found for DENV and WNV. Equines and hamsters showed antibodies to alphaviruses in all locations; two hamsters seroconverted to YFV in the Amazonia. Conclusions: The results show a YFV vaccination history and suggest the activity of arboviruses not included in the current surveillance scheme. Enhanced arbovirus and mosquito surveillance, as well as continued YFV vaccination and evaluation of its coverage/effectiveness, are recommended. |
format |
Article in Journal/Newspaper |
author |
Ernesto Gutiérrez-Vera Leandro Patiño Martha Castillo-Segovia Víctor Mora-Valencia Julio Montesdeoca-Agurto Mary Regato-Arrata |
author_facet |
Ernesto Gutiérrez-Vera Leandro Patiño Martha Castillo-Segovia Víctor Mora-Valencia Julio Montesdeoca-Agurto Mary Regato-Arrata |
author_sort |
Ernesto Gutiérrez-Vera |
title |
Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance |
title_short |
Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance |
title_full |
Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance |
title_fullStr |
Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance |
title_full_unstemmed |
Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance |
title_sort |
seroprevalence of arboviruses in ecuador: implications for improved surveillance |
publisher |
Instituto Nacional de Salud |
publishDate |
2021 |
url |
https://doi.org/10.7705/biomedica.5623 https://doaj.org/article/692efe20e23f491baca33cf5194a21b5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 41, Iss 2, Pp 247-259 (2021) |
op_relation |
https://revistabiomedica.org/index.php/biomedica/article/view/5623 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.5623 https://doaj.org/article/692efe20e23f491baca33cf5194a21b5 |
op_doi |
https://doi.org/10.7705/biomedica.5623 |
container_title |
Biomédica |
container_volume |
41 |
container_issue |
2 |
container_start_page |
247 |
op_container_end_page |
259 |
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1766341059210641408 |