The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids

• Published in: Malaria Journal
• Main Authors: Meyer David J, Adagu Ipemida S, Craig John C, Warhurst David C, Lee Sylvia Y
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2003
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Gauche
• Online Access: https://doi.org/10.1186/1475-2875-2-26; https://doaj.org/article/68aabdda05f9471a83371ff39d1284d5

Abstract Background The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo . From the X-ray structures a 90° difference in torsion angle between the N1-H1 and C9-O12 bonds in the two series is believed to be imp...