The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids
Abstract Background The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo . From the X-ray structures a 90° difference in torsion angle between the N1-H1 and C9-O12 bonds in the two series is believed to be imp...
Published in: | Malaria Journal |
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Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2003
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Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-2-26 https://doaj.org/article/68aabdda05f9471a83371ff39d1284d5 |