Soulamarin isolated from Calophyllum brasiliense (Clusiaceae) induces plasma membrane permeabilization of Trypanosoma cruzi and mytochondrial dysfunction.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Alexandre Rea, Andre G Tempone, Erika G Pinto, Juliana T Mesquita, Eliana Rodrigues, Luciana Grus M Silva, Patricia Sartorelli, João Henrique G Lago
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2013
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Triton
• Online Access: https://doi.org/10.1371/journal.pntd.0002556; https://doaj.org/article/686c41552dce40098b09ea231e2cbad1

Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi. It has high mortality as well as morbidity rates and usually affects the poorer sections of the population. The development of new, less harmful and more effective drugs is a promising research target, since current standard trea...