Isolation of Irkut virus from a Murina leucogaster bat in China.
BACKGROUND AND OBJECTIVES: Bats are recognized as a major reservoir of lyssaviruses; however, no bat lyssavirus has been isolated in Asia except for Aravan and Khujand virus in Central Asia. All Chinese lyssavirus isolates in previous reports have been of species rabies virus, mainly from dogs. Foll...
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ftdoajarticles:oai:doaj.org/article:6867aba9c15a4aca991d2d742bf67418 2023-05-15T15:10:57+02:00 Isolation of Irkut virus from a Murina leucogaster bat in China. Ye Liu Shoufeng Zhang Jinghui Zhao Fei Zhang Rongliang Hu 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002097 https://doaj.org/article/6867aba9c15a4aca991d2d742bf67418 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3591329?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0002097 https://doaj.org/article/6867aba9c15a4aca991d2d742bf67418 PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2097 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002097 2022-12-31T00:05:02Z BACKGROUND AND OBJECTIVES: Bats are recognized as a major reservoir of lyssaviruses; however, no bat lyssavirus has been isolated in Asia except for Aravan and Khujand virus in Central Asia. All Chinese lyssavirus isolates in previous reports have been of species rabies virus, mainly from dogs. Following at least two recent bat-associated human rabies-like cases in northeast China, we have initiated a study of the prevalence of lyssaviruses in bats in Jilin province and their public health implications. A bat lyssavirus has been isolated and its pathogenicity in mice and genomic alignment have been determined. RESULTS: We report the first isolation of a bat lyssavirus in China, from the brain of a northeastern bat, Murina leucogaster. Its nucleoprotein gene shared 92.4%/98.9% (nucleotide) and 92.2%/98.8% (amino acid) identity with the two known Irkut virus isolates from Russia, and was designated IRKV-THChina12. Following intracranial and intramuscular injection, IRKV-THChina12 produced rabies-like symptoms in adult mice with a short inoculation period and high mortality. Nucleotide sequence analysis showed that IRKV-THChina12 has the same genomic organization as other lyssaviruses and its isolation provides an independent origin for the species IRKV. CONCLUSIONS: We have identified the existence of a bat lyssavirus in a common Chinese bat species. Its high pathogenicity in adult mice suggests that public warnings and medical education regarding bat bites in China should be increased, and that surveillance be extended to provide a better understanding of Irkut virus ecology and its significance for public health. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 3 e2097 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ye Liu Shoufeng Zhang Jinghui Zhao Fei Zhang Rongliang Hu Isolation of Irkut virus from a Murina leucogaster bat in China. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND AND OBJECTIVES: Bats are recognized as a major reservoir of lyssaviruses; however, no bat lyssavirus has been isolated in Asia except for Aravan and Khujand virus in Central Asia. All Chinese lyssavirus isolates in previous reports have been of species rabies virus, mainly from dogs. Following at least two recent bat-associated human rabies-like cases in northeast China, we have initiated a study of the prevalence of lyssaviruses in bats in Jilin province and their public health implications. A bat lyssavirus has been isolated and its pathogenicity in mice and genomic alignment have been determined. RESULTS: We report the first isolation of a bat lyssavirus in China, from the brain of a northeastern bat, Murina leucogaster. Its nucleoprotein gene shared 92.4%/98.9% (nucleotide) and 92.2%/98.8% (amino acid) identity with the two known Irkut virus isolates from Russia, and was designated IRKV-THChina12. Following intracranial and intramuscular injection, IRKV-THChina12 produced rabies-like symptoms in adult mice with a short inoculation period and high mortality. Nucleotide sequence analysis showed that IRKV-THChina12 has the same genomic organization as other lyssaviruses and its isolation provides an independent origin for the species IRKV. CONCLUSIONS: We have identified the existence of a bat lyssavirus in a common Chinese bat species. Its high pathogenicity in adult mice suggests that public warnings and medical education regarding bat bites in China should be increased, and that surveillance be extended to provide a better understanding of Irkut virus ecology and its significance for public health. |
format |
Article in Journal/Newspaper |
author |
Ye Liu Shoufeng Zhang Jinghui Zhao Fei Zhang Rongliang Hu |
author_facet |
Ye Liu Shoufeng Zhang Jinghui Zhao Fei Zhang Rongliang Hu |
author_sort |
Ye Liu |
title |
Isolation of Irkut virus from a Murina leucogaster bat in China. |
title_short |
Isolation of Irkut virus from a Murina leucogaster bat in China. |
title_full |
Isolation of Irkut virus from a Murina leucogaster bat in China. |
title_fullStr |
Isolation of Irkut virus from a Murina leucogaster bat in China. |
title_full_unstemmed |
Isolation of Irkut virus from a Murina leucogaster bat in China. |
title_sort |
isolation of irkut virus from a murina leucogaster bat in china. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002097 https://doaj.org/article/6867aba9c15a4aca991d2d742bf67418 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2097 (2013) |
op_relation |
http://europepmc.org/articles/PMC3591329?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0002097 https://doaj.org/article/6867aba9c15a4aca991d2d742bf67418 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002097 |
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PLoS Neglected Tropical Diseases |
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7 |
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3 |
container_start_page |
e2097 |
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