Cardiomyopathy Associated With Coronary Arteriosclerosis in Free-Ranging Eurasian Lynx (Lynx lynx carpathicus)
The Eurasian lynx (subspecies Lynx lynx carpathicus) was reintroduced to Switzerland in the 1970's. Health monitoring of the reintroduced population started in the late 1980's. Since then, six lynx have been found affected by a myocardial disease. The earliest case was an animal that died...
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ftdoajarticles:oai:doaj.org/article:684b268fd2f34b98a054f46c3ea50b44 2023-05-15T18:50:23+02:00 Cardiomyopathy Associated With Coronary Arteriosclerosis in Free-Ranging Eurasian Lynx (Lynx lynx carpathicus) Marie-Pierre Ryser-Degiorgis Nadia Robert Roman Kaspar Meier Samoa Zürcher-Giovannini Mirjam Pewsner Andreas Ryser Urs Breitenmoser Alan Kovacevic Francesco C. Origgi 2020-12-01T00:00:00Z https://doi.org/10.3389/fvets.2020.594952 https://doaj.org/article/684b268fd2f34b98a054f46c3ea50b44 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fvets.2020.594952/full https://doaj.org/toc/2297-1769 2297-1769 doi:10.3389/fvets.2020.594952 https://doaj.org/article/684b268fd2f34b98a054f46c3ea50b44 Frontiers in Veterinary Science, Vol 7 (2020) cardiomegaly heart failure heart murmur lung edema myocardial fibrosis pathology Veterinary medicine SF600-1100 article 2020 ftdoajarticles https://doi.org/10.3389/fvets.2020.594952 2022-12-31T04:57:22Z The Eurasian lynx (subspecies Lynx lynx carpathicus) was reintroduced to Switzerland in the 1970's. Health monitoring of the reintroduced population started in the late 1980's. Since then, six lynx have been found affected by a myocardial disease. The earliest case was an animal that died after a field anesthesia. Two lynx were found dead, two were euthanized/culled because of disease signs, and one was hit by car. Two had a heart murmur at clinical examination. At necropsy, the first animal showed only lung edema but the other five had cardiomegaly associated with myocardial fibrosis. Three had multisystemic effusions. Histological examination of all six lynx showed mild to severe, multifocal, myocardial interstitial and perivascular fibrosis along with multifocal myocyte degeneration and loss, and replacement fibrosis. Moderate to severe multifocal arteriosclerosis with associated luminal stenosis of the small and medium-sized intramural coronary arteries and the presence of Anitschkow cells was also observed. The heart lesions may have led to sudden death in the first case and to a chronic right-sided heart failure in the remaining. None of the lynx showed lesions or signs suggestive of an acute or subacute infection. Given the common geographic origin of these animals and the severe loss of heterozygocity in this population, a genetic origin of the disease is hypothesized. Article in Journal/Newspaper Lynx Lynx lynx lynx Directory of Open Access Journals: DOAJ Articles Frontiers in Veterinary Science 7 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
cardiomegaly heart failure heart murmur lung edema myocardial fibrosis pathology Veterinary medicine SF600-1100 |
spellingShingle |
cardiomegaly heart failure heart murmur lung edema myocardial fibrosis pathology Veterinary medicine SF600-1100 Marie-Pierre Ryser-Degiorgis Nadia Robert Roman Kaspar Meier Samoa Zürcher-Giovannini Mirjam Pewsner Andreas Ryser Urs Breitenmoser Alan Kovacevic Francesco C. Origgi Cardiomyopathy Associated With Coronary Arteriosclerosis in Free-Ranging Eurasian Lynx (Lynx lynx carpathicus) |
topic_facet |
cardiomegaly heart failure heart murmur lung edema myocardial fibrosis pathology Veterinary medicine SF600-1100 |
description |
The Eurasian lynx (subspecies Lynx lynx carpathicus) was reintroduced to Switzerland in the 1970's. Health monitoring of the reintroduced population started in the late 1980's. Since then, six lynx have been found affected by a myocardial disease. The earliest case was an animal that died after a field anesthesia. Two lynx were found dead, two were euthanized/culled because of disease signs, and one was hit by car. Two had a heart murmur at clinical examination. At necropsy, the first animal showed only lung edema but the other five had cardiomegaly associated with myocardial fibrosis. Three had multisystemic effusions. Histological examination of all six lynx showed mild to severe, multifocal, myocardial interstitial and perivascular fibrosis along with multifocal myocyte degeneration and loss, and replacement fibrosis. Moderate to severe multifocal arteriosclerosis with associated luminal stenosis of the small and medium-sized intramural coronary arteries and the presence of Anitschkow cells was also observed. The heart lesions may have led to sudden death in the first case and to a chronic right-sided heart failure in the remaining. None of the lynx showed lesions or signs suggestive of an acute or subacute infection. Given the common geographic origin of these animals and the severe loss of heterozygocity in this population, a genetic origin of the disease is hypothesized. |
format |
Article in Journal/Newspaper |
author |
Marie-Pierre Ryser-Degiorgis Nadia Robert Roman Kaspar Meier Samoa Zürcher-Giovannini Mirjam Pewsner Andreas Ryser Urs Breitenmoser Alan Kovacevic Francesco C. Origgi |
author_facet |
Marie-Pierre Ryser-Degiorgis Nadia Robert Roman Kaspar Meier Samoa Zürcher-Giovannini Mirjam Pewsner Andreas Ryser Urs Breitenmoser Alan Kovacevic Francesco C. Origgi |
author_sort |
Marie-Pierre Ryser-Degiorgis |
title |
Cardiomyopathy Associated With Coronary Arteriosclerosis in Free-Ranging Eurasian Lynx (Lynx lynx carpathicus) |
title_short |
Cardiomyopathy Associated With Coronary Arteriosclerosis in Free-Ranging Eurasian Lynx (Lynx lynx carpathicus) |
title_full |
Cardiomyopathy Associated With Coronary Arteriosclerosis in Free-Ranging Eurasian Lynx (Lynx lynx carpathicus) |
title_fullStr |
Cardiomyopathy Associated With Coronary Arteriosclerosis in Free-Ranging Eurasian Lynx (Lynx lynx carpathicus) |
title_full_unstemmed |
Cardiomyopathy Associated With Coronary Arteriosclerosis in Free-Ranging Eurasian Lynx (Lynx lynx carpathicus) |
title_sort |
cardiomyopathy associated with coronary arteriosclerosis in free-ranging eurasian lynx (lynx lynx carpathicus) |
publisher |
Frontiers Media S.A. |
publishDate |
2020 |
url |
https://doi.org/10.3389/fvets.2020.594952 https://doaj.org/article/684b268fd2f34b98a054f46c3ea50b44 |
genre |
Lynx Lynx lynx lynx |
genre_facet |
Lynx Lynx lynx lynx |
op_source |
Frontiers in Veterinary Science, Vol 7 (2020) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fvets.2020.594952/full https://doaj.org/toc/2297-1769 2297-1769 doi:10.3389/fvets.2020.594952 https://doaj.org/article/684b268fd2f34b98a054f46c3ea50b44 |
op_doi |
https://doi.org/10.3389/fvets.2020.594952 |
container_title |
Frontiers in Veterinary Science |
container_volume |
7 |
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1766244105217638400 |