Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study
Abstract Background Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Natio...
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ftdoajarticles:oai:doaj.org/article:683cd05cebc64ae2b4671822071161ec 2023-05-15T16:17:08+02:00 Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study Zacharias James Young T Riediger Natalie D Roulette Joanne Bruce Sharon G 2012-04-01T00:00:00Z https://doi.org/10.1186/1471-2458-12-290 https://doaj.org/article/683cd05cebc64ae2b4671822071161ec EN eng BMC http://www.biomedcentral.com/1471-2458/12/290 https://doaj.org/toc/1471-2458 doi:10.1186/1471-2458-12-290 1471-2458 https://doaj.org/article/683cd05cebc64ae2b4671822071161ec BMC Public Health, Vol 12, Iss 1, p 290 (2012) Canada First Nation Albuminuria End-stage renal disease Kidney Diabetes Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1186/1471-2458-12-290 2022-12-31T08:35:03Z Abstract Background Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Nation population at high risk for ESRD and dialysis. Methods Data from a community-based screening study of 483 residents of a Plains Ojibway First Nation in Manitoba was used. Participants provided random urine samples. Proteinuria was defined as any dipstick positive for protein (≥1 g/L) or those with ACR in the macroalbuminuric range (≥30 mg/mmol) on at least one sample. Microalbuminuria was defined as ACR ≥2 mg/mmol for males and ≥2.8 mg/mmol for females. Other measures included fasting glucose, haemoglobin A 1c , triglycerides, cholesterol, blood pressure, height, weight and waist and hip circumferences. Results Twenty percent of study participants had albuminuria, (5% proteinuria and 15% microalbuminuria). Of participants with diabetes, 42% (56/132) had albuminuria compared to 26% (7/27) among those with impaired fasting glucose and 10% (30/303) among those with normal glucose tolerance. Only 5.3% of those with albuminuria were aware of any degree of renal disease. In a multivariate logistic regression, independent associations with albuminuria were male gender [p = 0.002], increasing fasting glucose [p <0.0001], years diagnosed with diabetes [p = 0.03], increasing systolic blood pressure [p = 0.009], and increasing body mass index (BMI) [p = 0.04]. Conclusions The independent association between BMI and albuminuria has not been previously reported among indigenous populations. There is a high prevalence of albuminuria in this Canadian First Nation population; the high proportion of patients with diabetes and undiagnosed kidney disease demonstrates the need for screening, education and intervention to halt the progression and development of albuminuria and ultimately ESRD and CVD. Article in Journal/Newspaper First Nations Directory of Open Access Journals: DOAJ Articles Canada BMC Public Health 12 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Canada First Nation Albuminuria End-stage renal disease Kidney Diabetes Public aspects of medicine RA1-1270 |
spellingShingle |
Canada First Nation Albuminuria End-stage renal disease Kidney Diabetes Public aspects of medicine RA1-1270 Zacharias James Young T Riediger Natalie D Roulette Joanne Bruce Sharon G Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
topic_facet |
Canada First Nation Albuminuria End-stage renal disease Kidney Diabetes Public aspects of medicine RA1-1270 |
description |
Abstract Background Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Nation population at high risk for ESRD and dialysis. Methods Data from a community-based screening study of 483 residents of a Plains Ojibway First Nation in Manitoba was used. Participants provided random urine samples. Proteinuria was defined as any dipstick positive for protein (≥1 g/L) or those with ACR in the macroalbuminuric range (≥30 mg/mmol) on at least one sample. Microalbuminuria was defined as ACR ≥2 mg/mmol for males and ≥2.8 mg/mmol for females. Other measures included fasting glucose, haemoglobin A 1c , triglycerides, cholesterol, blood pressure, height, weight and waist and hip circumferences. Results Twenty percent of study participants had albuminuria, (5% proteinuria and 15% microalbuminuria). Of participants with diabetes, 42% (56/132) had albuminuria compared to 26% (7/27) among those with impaired fasting glucose and 10% (30/303) among those with normal glucose tolerance. Only 5.3% of those with albuminuria were aware of any degree of renal disease. In a multivariate logistic regression, independent associations with albuminuria were male gender [p = 0.002], increasing fasting glucose [p <0.0001], years diagnosed with diabetes [p = 0.03], increasing systolic blood pressure [p = 0.009], and increasing body mass index (BMI) [p = 0.04]. Conclusions The independent association between BMI and albuminuria has not been previously reported among indigenous populations. There is a high prevalence of albuminuria in this Canadian First Nation population; the high proportion of patients with diabetes and undiagnosed kidney disease demonstrates the need for screening, education and intervention to halt the progression and development of albuminuria and ultimately ESRD and CVD. |
format |
Article in Journal/Newspaper |
author |
Zacharias James Young T Riediger Natalie D Roulette Joanne Bruce Sharon G |
author_facet |
Zacharias James Young T Riediger Natalie D Roulette Joanne Bruce Sharon G |
author_sort |
Zacharias James |
title |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_short |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_full |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_fullStr |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_full_unstemmed |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_sort |
prevalence, risk factors and awareness of albuminuria on a canadian first nation: a community-based screening study |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1471-2458-12-290 https://doaj.org/article/683cd05cebc64ae2b4671822071161ec |
geographic |
Canada |
geographic_facet |
Canada |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
BMC Public Health, Vol 12, Iss 1, p 290 (2012) |
op_relation |
http://www.biomedcentral.com/1471-2458/12/290 https://doaj.org/toc/1471-2458 doi:10.1186/1471-2458-12-290 1471-2458 https://doaj.org/article/683cd05cebc64ae2b4671822071161ec |
op_doi |
https://doi.org/10.1186/1471-2458-12-290 |
container_title |
BMC Public Health |
container_volume |
12 |
container_issue |
1 |
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1766002972101181440 |