Kaempferol and its derivatives: Biological activities and therapeutic potential

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Shazia Parveen, Irshad Ul Haq Bhat, Rajeev Bhat
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2023
• Subjects: kaempferol; therapeutic effects; bioactivities; fruits and vegetable wastes; sustainable alternative sources; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic; Pillar
• Online Access: https://doi.org/10.4103/2221-1691.387747; https://doaj.org/article/681b206a69b445348553cadf6775abf7

Kaempferol, a natural plant-origin flavonoid, exhibits therapeutic anti-inflammatory, antioxidant, anticancer, antidiabetic, and neuroprotective properties. Kaempferol acts within several distinct mechanisms like apoptotic induction in cancer cells, enzymatic inhibition, signalling pathway inhibition, and downregulation in cell viability during the G2/M phase of cell division. This review summarizes the therapeutic effects of kaempferol against several health ailments. The recent progress on kaempferol obtained from fruits and vegetables as an antioxidant, anti-inflammatory, anticancer, antidiabetic, and neuroprotective agent and its mechanisms of action are also discussed. In addition, kaempferol has been reported to be present in wastes and byproducts from post-fruit and vegetable processing. Thus, a paradigm shift towards valorizing fruits and vegetable industrial wastes/byproducts to obtain bioactive kaempferol can support the circular economy pillar for generating wealth from waste and for finding a sustainable alternative source.