Association between TNF -308G/A polymorphism and susceptibility to pulmonary tuberculosis in the Lur population of Iran
Objective: To investigate whether tumor necrosis factor-α (TNFα) -238G/A and -308G/A polymorphisms are associated with susceptibility to pulmonary tuberculosis (TB) in the Lur ethnic population of Iran. Methods: TNF polymorphisms genotyping was performed by polymerase chain reaction-restriction frag...
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ftdoajarticles:oai:doaj.org/article:680309d4be15410188fbd82c1752d96f 2023-05-15T15:09:17+02:00 Association between TNF -308G/A polymorphism and susceptibility to pulmonary tuberculosis in the Lur population of Iran Farhad Shahsavar Ali Mohammad Varzi Alireza Azargoon 2016-01-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.09.017 https://doaj.org/article/680309d4be15410188fbd82c1752d96f EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115002373 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.09.017 https://doaj.org/article/680309d4be15410188fbd82c1752d96f Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 1, Pp 80-83 (2016) TNFα polymorphism Tuberculosis Pulmonary tuberculosis Lur population Iran Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.09.017 2022-12-31T03:12:54Z Objective: To investigate whether tumor necrosis factor-α (TNFα) -238G/A and -308G/A polymorphisms are associated with susceptibility to pulmonary tuberculosis (TB) in the Lur ethnic population of Iran. Methods: TNF polymorphisms genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism method in 100 pulmonary TB patients and 100 healthy controls from the Lur population. Results: The allelic and genotypic frequencies of TNFα -238G/A polymorphism were not significantly different between the pulmonary TB patients and the healthy controls. However, the TNFα -308G/A polymorphism showed a significantly higher frequency of genotype GG in TB subjects compared to healthy controls (94% in the patients vs. 62% in the controls, P = 0.0001, odds ratio = 0.104, confidence interval = 0.028–0.382). Moreover, in the TNFα -308G/A polymorphism, a significantly higher frequency of G allele was measured in the patient group compared with the control group (97% in the patient group vs. 81% in the control group, P = 0.0001, odds ratio = 0.132, confidence interval = 0.038–0.462). Conclusions: Our findings suggest that TNFα -308G/A polymorphism may increase the susceptibility to pulmonary TB in the Lur population of Iran. Despite TNFα polymorphisms and susceptibility to pulmonary TB, we suggest that more studies with larger sample size are needed in the future. Increasing our understanding of susceptibility risk factors may help to improve current preventive measures and treatment for TB. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 1 80 83 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
TNFα polymorphism Tuberculosis Pulmonary tuberculosis Lur population Iran Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
TNFα polymorphism Tuberculosis Pulmonary tuberculosis Lur population Iran Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Farhad Shahsavar Ali Mohammad Varzi Alireza Azargoon Association between TNF -308G/A polymorphism and susceptibility to pulmonary tuberculosis in the Lur population of Iran |
topic_facet |
TNFα polymorphism Tuberculosis Pulmonary tuberculosis Lur population Iran Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate whether tumor necrosis factor-α (TNFα) -238G/A and -308G/A polymorphisms are associated with susceptibility to pulmonary tuberculosis (TB) in the Lur ethnic population of Iran. Methods: TNF polymorphisms genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism method in 100 pulmonary TB patients and 100 healthy controls from the Lur population. Results: The allelic and genotypic frequencies of TNFα -238G/A polymorphism were not significantly different between the pulmonary TB patients and the healthy controls. However, the TNFα -308G/A polymorphism showed a significantly higher frequency of genotype GG in TB subjects compared to healthy controls (94% in the patients vs. 62% in the controls, P = 0.0001, odds ratio = 0.104, confidence interval = 0.028–0.382). Moreover, in the TNFα -308G/A polymorphism, a significantly higher frequency of G allele was measured in the patient group compared with the control group (97% in the patient group vs. 81% in the control group, P = 0.0001, odds ratio = 0.132, confidence interval = 0.038–0.462). Conclusions: Our findings suggest that TNFα -308G/A polymorphism may increase the susceptibility to pulmonary TB in the Lur population of Iran. Despite TNFα polymorphisms and susceptibility to pulmonary TB, we suggest that more studies with larger sample size are needed in the future. Increasing our understanding of susceptibility risk factors may help to improve current preventive measures and treatment for TB. |
format |
Article in Journal/Newspaper |
author |
Farhad Shahsavar Ali Mohammad Varzi Alireza Azargoon |
author_facet |
Farhad Shahsavar Ali Mohammad Varzi Alireza Azargoon |
author_sort |
Farhad Shahsavar |
title |
Association between TNF -308G/A polymorphism and susceptibility to pulmonary tuberculosis in the Lur population of Iran |
title_short |
Association between TNF -308G/A polymorphism and susceptibility to pulmonary tuberculosis in the Lur population of Iran |
title_full |
Association between TNF -308G/A polymorphism and susceptibility to pulmonary tuberculosis in the Lur population of Iran |
title_fullStr |
Association between TNF -308G/A polymorphism and susceptibility to pulmonary tuberculosis in the Lur population of Iran |
title_full_unstemmed |
Association between TNF -308G/A polymorphism and susceptibility to pulmonary tuberculosis in the Lur population of Iran |
title_sort |
association between tnf -308g/a polymorphism and susceptibility to pulmonary tuberculosis in the lur population of iran |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2015.09.017 https://doaj.org/article/680309d4be15410188fbd82c1752d96f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 1, Pp 80-83 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115002373 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.09.017 https://doaj.org/article/680309d4be15410188fbd82c1752d96f |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.09.017 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
1 |
container_start_page |
80 |
op_container_end_page |
83 |
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1766340493095993344 |