Insecticidal action of synthetic girgensohnine analogues and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae)
Introduction: The alkaloid girgensohnine has been used as a natural model in the synthesis of new alkaloid-like alpha-aminonitriles with insecticidal effect against disease vectors. Objective: To evaluate the biocide activity of girgensohnine analogues and essential oils of Cymbopogon flexuosus, Cit...
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Instituto Nacional de Salud
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ftdoajarticles:oai:doaj.org/article:677425a7939948fcb96b1699b3899986 2023-05-15T15:12:40+02:00 Insecticidal action of synthetic girgensohnine analogues and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae) Juliana Cuadros Aurora L. Carreño Vladimir V. Kouznetsov Jonny E. Duque 2017-03-01T00:00:00Z https://doi.org/10.7705/biomedica.v37i0.3379 https://doaj.org/article/677425a7939948fcb96b1699b3899986 EN ES eng spa Instituto Nacional de Salud https://www.revistabiomedica.org/index.php/biomedica/article/view/3379 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v37i0.3379 https://doaj.org/article/677425a7939948fcb96b1699b3899986 Biomédica: revista del Instituto Nacional de Salud, Vol 37, Iss 0, Pp 50-58 (2017) Triatominae Chagas disease insecticides oils volatile Medicine R Arctic medicine. Tropical medicine RC955-962 article 2017 ftdoajarticles https://doi.org/10.7705/biomedica.v37i0.3379 2022-12-31T02:07:48Z Introduction: The alkaloid girgensohnine has been used as a natural model in the synthesis of new alkaloid-like alpha-aminonitriles with insecticidal effect against disease vectors. Objective: To evaluate the biocide activity of girgensohnine analogues and essential oils of Cymbopogon flexuosus, Citrus sinensis and Eucalyptus citriodora in stage I and stage V Rhodnius prolixus nymphs. Materials and methods: We used a topical application model in tergites and sternites, as well as exposure to treated surfaces with different exploratory doses of each of the molecules and essential oils to determine the lethal doses (LD50 and LD95). Results: Analogue 3 showed the highest insecticidal activity with 83.3±16.7% of mortality when applied on tergites, 38.9±4.8% on sternites and 16.7±0% on treated surfaces in stage I nymphs at 72 hours (h) and 500 mg.L-1. In stage V nymphs, the compounds induced mortality only in sternums (11.1±9.6% for analogue 6 and 5.5±4.7% for analogues 3 and 7 at 72 h and 1500 mg.L-1). The lethal doses for molecule 3 on tergites in stage I nymphs were LD50 225.60 mg.L-1 and LD95 955.90 mg.L-1. The insecticidal effect of essential oils was observed only in stage I nymphs, with 11.1±4.8% for C. flexuosus when applied in sternites, while using exposure to surfaces treated it was 5.6±4.8% for C. sinensis applied on tergites and 8.3±0% on sternites at 72 h and 1000 mg.L-1. Conclusion: Synthetic girgensohnine analogues, and C. flexuosus and C. sinensis essential oils showed insecticidal activity in R. prolixus. Analogue 3 showed the greatest insecticidal activity among all molecules and oils evaluated under our laboratory conditions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 37 50 |
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English Spanish |
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Triatominae Chagas disease insecticides oils volatile Medicine R Arctic medicine. Tropical medicine RC955-962 |
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Triatominae Chagas disease insecticides oils volatile Medicine R Arctic medicine. Tropical medicine RC955-962 Juliana Cuadros Aurora L. Carreño Vladimir V. Kouznetsov Jonny E. Duque Insecticidal action of synthetic girgensohnine analogues and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae) |
topic_facet |
Triatominae Chagas disease insecticides oils volatile Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction: The alkaloid girgensohnine has been used as a natural model in the synthesis of new alkaloid-like alpha-aminonitriles with insecticidal effect against disease vectors. Objective: To evaluate the biocide activity of girgensohnine analogues and essential oils of Cymbopogon flexuosus, Citrus sinensis and Eucalyptus citriodora in stage I and stage V Rhodnius prolixus nymphs. Materials and methods: We used a topical application model in tergites and sternites, as well as exposure to treated surfaces with different exploratory doses of each of the molecules and essential oils to determine the lethal doses (LD50 and LD95). Results: Analogue 3 showed the highest insecticidal activity with 83.3±16.7% of mortality when applied on tergites, 38.9±4.8% on sternites and 16.7±0% on treated surfaces in stage I nymphs at 72 hours (h) and 500 mg.L-1. In stage V nymphs, the compounds induced mortality only in sternums (11.1±9.6% for analogue 6 and 5.5±4.7% for analogues 3 and 7 at 72 h and 1500 mg.L-1). The lethal doses for molecule 3 on tergites in stage I nymphs were LD50 225.60 mg.L-1 and LD95 955.90 mg.L-1. The insecticidal effect of essential oils was observed only in stage I nymphs, with 11.1±4.8% for C. flexuosus when applied in sternites, while using exposure to surfaces treated it was 5.6±4.8% for C. sinensis applied on tergites and 8.3±0% on sternites at 72 h and 1000 mg.L-1. Conclusion: Synthetic girgensohnine analogues, and C. flexuosus and C. sinensis essential oils showed insecticidal activity in R. prolixus. Analogue 3 showed the greatest insecticidal activity among all molecules and oils evaluated under our laboratory conditions. |
format |
Article in Journal/Newspaper |
author |
Juliana Cuadros Aurora L. Carreño Vladimir V. Kouznetsov Jonny E. Duque |
author_facet |
Juliana Cuadros Aurora L. Carreño Vladimir V. Kouznetsov Jonny E. Duque |
author_sort |
Juliana Cuadros |
title |
Insecticidal action of synthetic girgensohnine analogues and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae) |
title_short |
Insecticidal action of synthetic girgensohnine analogues and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae) |
title_full |
Insecticidal action of synthetic girgensohnine analogues and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae) |
title_fullStr |
Insecticidal action of synthetic girgensohnine analogues and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae) |
title_full_unstemmed |
Insecticidal action of synthetic girgensohnine analogues and essential oils on Rhodnius prolixus (Hemiptera: Reduviidae) |
title_sort |
insecticidal action of synthetic girgensohnine analogues and essential oils on rhodnius prolixus (hemiptera: reduviidae) |
publisher |
Instituto Nacional de Salud |
publishDate |
2017 |
url |
https://doi.org/10.7705/biomedica.v37i0.3379 https://doaj.org/article/677425a7939948fcb96b1699b3899986 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 37, Iss 0, Pp 50-58 (2017) |
op_relation |
https://www.revistabiomedica.org/index.php/biomedica/article/view/3379 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v37i0.3379 https://doaj.org/article/677425a7939948fcb96b1699b3899986 |
op_doi |
https://doi.org/10.7705/biomedica.v37i0.3379 |
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Biomédica |
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37 |
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50 |
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1766343321304694784 |