A preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia
Abstract Background Malaria is an annual killer of over one million people globally and its essential co-morbidity is anaemia. Cord blood, because of its rich mix of foetal and adult haemoglobin, high platelet and WBC counts, hypo-antigenic nature, altered metabolic profile and high affinity for oxy...
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ftdoajarticles:oai:doaj.org/article:674aaf5a704a422ba65b3962eb81fdfe 2023-05-15T15:18:13+02:00 A preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia Bhattacharya Niranjan 2006-03-01T00:00:00Z https://doi.org/10.1186/1475-2875-5-20 https://doaj.org/article/674aaf5a704a422ba65b3962eb81fdfe EN eng BMC http://www.malariajournal.com/content/5/1/20 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-5-20 1475-2875 https://doaj.org/article/674aaf5a704a422ba65b3962eb81fdfe Malaria Journal, Vol 5, Iss 1, p 20 (2006) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2006 ftdoajarticles https://doi.org/10.1186/1475-2875-5-20 2022-12-30T22:25:41Z Abstract Background Malaria is an annual killer of over one million people globally and its essential co-morbidity is anaemia. Cord blood, because of its rich mix of foetal and adult haemoglobin, high platelet and WBC counts, hypo-antigenic nature, altered metabolic profile and high affinity for oxygen as well as its anti-malarial effect, is an ideal choice in malaria with anaemia, necessitating blood transfusion. Methods This paper presents an alternative protocol for fresh whole blood/packed cell transfusion from the hospital's biological waste resources, i.e., the placenta, after the birth of a healthy baby from a healthy mother. This collected blood was routinely transfused to patients admitted in our hospital with severe anaemia in the background of confirmed malaria. 94 units of placental umbilical cord whole blood were collected after lower uterine caesarean section (LUCS) from consenting mothers (from 1 st April 1999 to April 2005), and safely transfused to 39 informed, consenting patients (age varying from 8 to 72 years). The collected volume of cord blood from each placenta (Unit) varied from 52 ml to 143 ml, with a mean packed cell volume of 48.9 ± 4.1 SD and a mean haemoglobin concentration of 16.4 Gm percent ± 1.6 Gm percent SD. The blood was immediately transfused after following the standard adult blood transfusion protocol of screening and cross-matching between the donor and the recipient. On occasion, the collected cord blood was preserved in the refrigerator, if no volunteer was readily available, and transfused within 72 hours of collection. Results Cord blood transfusion was tested on twenty two patients infected with Plasmodium falciparum and 17 patients with Plasmodium vivax . For inclusion in this study, the patient's plasma haemoglobin had to be 8 gm percent or less (the pre-transfusion haemoglobin in the malaria-infected patients in this series varied from 5.4 gm/dl to 7.9 gm/dl). The rise of haemoglobin within 72 hours of two units of freshly collected cord blood transfusion was 0.5 ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 5 1 20 |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Bhattacharya Niranjan A preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria is an annual killer of over one million people globally and its essential co-morbidity is anaemia. Cord blood, because of its rich mix of foetal and adult haemoglobin, high platelet and WBC counts, hypo-antigenic nature, altered metabolic profile and high affinity for oxygen as well as its anti-malarial effect, is an ideal choice in malaria with anaemia, necessitating blood transfusion. Methods This paper presents an alternative protocol for fresh whole blood/packed cell transfusion from the hospital's biological waste resources, i.e., the placenta, after the birth of a healthy baby from a healthy mother. This collected blood was routinely transfused to patients admitted in our hospital with severe anaemia in the background of confirmed malaria. 94 units of placental umbilical cord whole blood were collected after lower uterine caesarean section (LUCS) from consenting mothers (from 1 st April 1999 to April 2005), and safely transfused to 39 informed, consenting patients (age varying from 8 to 72 years). The collected volume of cord blood from each placenta (Unit) varied from 52 ml to 143 ml, with a mean packed cell volume of 48.9 ± 4.1 SD and a mean haemoglobin concentration of 16.4 Gm percent ± 1.6 Gm percent SD. The blood was immediately transfused after following the standard adult blood transfusion protocol of screening and cross-matching between the donor and the recipient. On occasion, the collected cord blood was preserved in the refrigerator, if no volunteer was readily available, and transfused within 72 hours of collection. Results Cord blood transfusion was tested on twenty two patients infected with Plasmodium falciparum and 17 patients with Plasmodium vivax . For inclusion in this study, the patient's plasma haemoglobin had to be 8 gm percent or less (the pre-transfusion haemoglobin in the malaria-infected patients in this series varied from 5.4 gm/dl to 7.9 gm/dl). The rise of haemoglobin within 72 hours of two units of freshly collected cord blood transfusion was 0.5 ... |
format |
Article in Journal/Newspaper |
author |
Bhattacharya Niranjan |
author_facet |
Bhattacharya Niranjan |
author_sort |
Bhattacharya Niranjan |
title |
A preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia |
title_short |
A preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia |
title_full |
A preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia |
title_fullStr |
A preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia |
title_full_unstemmed |
A preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia |
title_sort |
preliminary study of placental umbilical cord whole blood transfusion in under resourced patients with malaria in the background of anaemia |
publisher |
BMC |
publishDate |
2006 |
url |
https://doi.org/10.1186/1475-2875-5-20 https://doaj.org/article/674aaf5a704a422ba65b3962eb81fdfe |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 5, Iss 1, p 20 (2006) |
op_relation |
http://www.malariajournal.com/content/5/1/20 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-5-20 1475-2875 https://doaj.org/article/674aaf5a704a422ba65b3962eb81fdfe |
op_doi |
https://doi.org/10.1186/1475-2875-5-20 |
container_title |
Malaria Journal |
container_volume |
5 |
container_issue |
1 |
container_start_page |
20 |
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1766348438842114048 |