The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study.
BACKGROUND: Erythema nodosum leprosum (ENL) is a debilitating multisystem disorder which complicates leprosy. It is characterised by fever, malaise and painful erythematous cutaneous nodules. ENL is often recurrent or chronic in nature and frequently severe. Patients often require prolonged treatmen...
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ftdoajarticles:oai:doaj.org/article:67335b60c243412182d0456c830f65c4 2023-05-15T15:07:47+02:00 The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study. Stephen L Walker Eglantine Lebas Shimelis N Doni Diana N J Lockwood Saba M Lambert 2014-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002690 https://doaj.org/article/67335b60c243412182d0456c830f65c4 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3953021?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002690 https://doaj.org/article/67335b60c243412182d0456c830f65c4 PLoS Neglected Tropical Diseases, Vol 8, Iss 3, p e2690 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002690 2022-12-31T13:27:19Z BACKGROUND: Erythema nodosum leprosum (ENL) is a debilitating multisystem disorder which complicates leprosy. It is characterised by fever, malaise and painful erythematous cutaneous nodules. ENL is often recurrent or chronic in nature and frequently severe. Patients often require prolonged treatment with high doses of oral corticosteroids. There are no data on the mortality associated with treated ENL. METHODOLOGY: The notes of patients who were admitted, discharged, transferred to another facility or died with a diagnosis of leprosy or a leprosy-related complication for a five year period were reviewed. RESULT/DISCUSSION: 414 individuals were identified from the ward database. 312 (75.4%) patient records were located and reviewed. Ninety-nine individuals had ENL and 145 had a Type 1 reaction. The median age of individuals with ENLwas 25 years. Eight patients with erythema nodosum leprosum died compared with two diagnosed with Type 1 reaction. This difference is statistically significant (p = 0.0168, Fisher's Exact Test). There is a significant mortality and morbidity associated with ENL in this Ethiopian cohort. The adverse outcomes seen are largely attributable to the chronic administration of oral corticosteroids used to control the inflammatory and debilitating symptoms of the condition. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 3 e2690 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Stephen L Walker Eglantine Lebas Shimelis N Doni Diana N J Lockwood Saba M Lambert The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Erythema nodosum leprosum (ENL) is a debilitating multisystem disorder which complicates leprosy. It is characterised by fever, malaise and painful erythematous cutaneous nodules. ENL is often recurrent or chronic in nature and frequently severe. Patients often require prolonged treatment with high doses of oral corticosteroids. There are no data on the mortality associated with treated ENL. METHODOLOGY: The notes of patients who were admitted, discharged, transferred to another facility or died with a diagnosis of leprosy or a leprosy-related complication for a five year period were reviewed. RESULT/DISCUSSION: 414 individuals were identified from the ward database. 312 (75.4%) patient records were located and reviewed. Ninety-nine individuals had ENL and 145 had a Type 1 reaction. The median age of individuals with ENLwas 25 years. Eight patients with erythema nodosum leprosum died compared with two diagnosed with Type 1 reaction. This difference is statistically significant (p = 0.0168, Fisher's Exact Test). There is a significant mortality and morbidity associated with ENL in this Ethiopian cohort. The adverse outcomes seen are largely attributable to the chronic administration of oral corticosteroids used to control the inflammatory and debilitating symptoms of the condition. |
format |
Article in Journal/Newspaper |
author |
Stephen L Walker Eglantine Lebas Shimelis N Doni Diana N J Lockwood Saba M Lambert |
author_facet |
Stephen L Walker Eglantine Lebas Shimelis N Doni Diana N J Lockwood Saba M Lambert |
author_sort |
Stephen L Walker |
title |
The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study. |
title_short |
The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study. |
title_full |
The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study. |
title_fullStr |
The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study. |
title_full_unstemmed |
The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study. |
title_sort |
mortality associated with erythema nodosum leprosum in ethiopia: a retrospective hospital-based study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002690 https://doaj.org/article/67335b60c243412182d0456c830f65c4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 3, p e2690 (2014) |
op_relation |
http://europepmc.org/articles/PMC3953021?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002690 https://doaj.org/article/67335b60c243412182d0456c830f65c4 |
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https://doi.org/10.1371/journal.pntd.0002690 |
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PLoS Neglected Tropical Diseases |
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e2690 |
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