Dynamics of anti-malarial antibodies in non-immune patients during and after a first and unique Plasmodium falciparum malaria episode
Abstract Background Malaria is a major travel medicine issue. Retrospective confirmation of a malaria episode diagnosed in an endemic area can have relevant implications in transfusional medicine in Europe, where blood donors are excluded from donation on the basis of positive malaria serology. Howe...
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ftdoajarticles:oai:doaj.org/article:669a37ff566f4c02967c6d1755727b0f 2023-05-15T15:17:33+02:00 Dynamics of anti-malarial antibodies in non-immune patients during and after a first and unique Plasmodium falciparum malaria episode Zeno Bisoffi Marco Bertoldi Ronaldo Silva Giulia Bertoli Tamara Ursini Stefania Marocco Chiara Piubelli Elena Pomari Dora Buonfrate Federico Gobbi 2020-06-01T00:00:00Z https://doi.org/10.1186/s12936-020-03300-x https://doaj.org/article/669a37ff566f4c02967c6d1755727b0f EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03300-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03300-x 1475-2875 https://doaj.org/article/669a37ff566f4c02967c6d1755727b0f Malaria Journal, Vol 19, Iss 1, Pp 1-8 (2020) Malaria Plasmodium falciparum Imported Non-immune Antibodies IFAT Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03300-x 2023-01-08T01:32:58Z Abstract Background Malaria is a major travel medicine issue. Retrospective confirmation of a malaria episode diagnosed in an endemic area can have relevant implications in transfusional medicine in Europe, where blood donors are excluded from donation on the basis of positive malaria serology. However, there is scarce evidence on the dynamics of anti-malarial antibodies after a first malaria episode in non-immune individuals. The first aim of this study was to describe the dynamics of anti-malarial antibodies in a first malaria episode in non-immune travellers. Secondary objectives were to assess the sensitivity of serology for a retrospective diagnosis in non-immune travellers diagnosed while abroad and to discuss the implications in transfusional medicine. Methods Retrospective analysis of the results of an indirect fluorescence antibody test (IFAT) for malaria available for patients with a first malaria episode by Plasmodium falciparum and admitted at the IRCCS Sacro Cuore Don Calabria hospital in a 14-year period. The antibody titres were collected at baseline and during further follow up visits. Epidemiological, demographic and laboratory test results (including full blood count and malaria parasite density) were anonymously recorded in a study specific electronic Case Report Form created with OpenClinica software. Statistical analysis was performed with SAS software version 9.4. Results Thirty-six patients were included. Among them, all but two were Europeans (one African and one American). Median length of fever before diagnosis was 2 days (IQR 1–3). Thirty-five patients had seroconversion between day 1 and day 4 from admission, and the titre showed a sharply rising titre, often to a very high level in a few days. Only a single patient remained negative in the first 5 days from admission, after which he was no more tested. Six patients were followed up for at least 2 months, and they all showed a decline in IFAT titre, tending to seroreversion (confirmed in one patient with the longest follow up, almost ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Plasmodium falciparum Imported Non-immune Antibodies IFAT Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Plasmodium falciparum Imported Non-immune Antibodies IFAT Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Zeno Bisoffi Marco Bertoldi Ronaldo Silva Giulia Bertoli Tamara Ursini Stefania Marocco Chiara Piubelli Elena Pomari Dora Buonfrate Federico Gobbi Dynamics of anti-malarial antibodies in non-immune patients during and after a first and unique Plasmodium falciparum malaria episode |
topic_facet |
Malaria Plasmodium falciparum Imported Non-immune Antibodies IFAT Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria is a major travel medicine issue. Retrospective confirmation of a malaria episode diagnosed in an endemic area can have relevant implications in transfusional medicine in Europe, where blood donors are excluded from donation on the basis of positive malaria serology. However, there is scarce evidence on the dynamics of anti-malarial antibodies after a first malaria episode in non-immune individuals. The first aim of this study was to describe the dynamics of anti-malarial antibodies in a first malaria episode in non-immune travellers. Secondary objectives were to assess the sensitivity of serology for a retrospective diagnosis in non-immune travellers diagnosed while abroad and to discuss the implications in transfusional medicine. Methods Retrospective analysis of the results of an indirect fluorescence antibody test (IFAT) for malaria available for patients with a first malaria episode by Plasmodium falciparum and admitted at the IRCCS Sacro Cuore Don Calabria hospital in a 14-year period. The antibody titres were collected at baseline and during further follow up visits. Epidemiological, demographic and laboratory test results (including full blood count and malaria parasite density) were anonymously recorded in a study specific electronic Case Report Form created with OpenClinica software. Statistical analysis was performed with SAS software version 9.4. Results Thirty-six patients were included. Among them, all but two were Europeans (one African and one American). Median length of fever before diagnosis was 2 days (IQR 1–3). Thirty-five patients had seroconversion between day 1 and day 4 from admission, and the titre showed a sharply rising titre, often to a very high level in a few days. Only a single patient remained negative in the first 5 days from admission, after which he was no more tested. Six patients were followed up for at least 2 months, and they all showed a decline in IFAT titre, tending to seroreversion (confirmed in one patient with the longest follow up, almost ... |
format |
Article in Journal/Newspaper |
author |
Zeno Bisoffi Marco Bertoldi Ronaldo Silva Giulia Bertoli Tamara Ursini Stefania Marocco Chiara Piubelli Elena Pomari Dora Buonfrate Federico Gobbi |
author_facet |
Zeno Bisoffi Marco Bertoldi Ronaldo Silva Giulia Bertoli Tamara Ursini Stefania Marocco Chiara Piubelli Elena Pomari Dora Buonfrate Federico Gobbi |
author_sort |
Zeno Bisoffi |
title |
Dynamics of anti-malarial antibodies in non-immune patients during and after a first and unique Plasmodium falciparum malaria episode |
title_short |
Dynamics of anti-malarial antibodies in non-immune patients during and after a first and unique Plasmodium falciparum malaria episode |
title_full |
Dynamics of anti-malarial antibodies in non-immune patients during and after a first and unique Plasmodium falciparum malaria episode |
title_fullStr |
Dynamics of anti-malarial antibodies in non-immune patients during and after a first and unique Plasmodium falciparum malaria episode |
title_full_unstemmed |
Dynamics of anti-malarial antibodies in non-immune patients during and after a first and unique Plasmodium falciparum malaria episode |
title_sort |
dynamics of anti-malarial antibodies in non-immune patients during and after a first and unique plasmodium falciparum malaria episode |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03300-x https://doaj.org/article/669a37ff566f4c02967c6d1755727b0f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-8 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03300-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03300-x 1475-2875 https://doaj.org/article/669a37ff566f4c02967c6d1755727b0f |
op_doi |
https://doi.org/10.1186/s12936-020-03300-x |
container_title |
Malaria Journal |
container_volume |
19 |
container_issue |
1 |
_version_ |
1766347797940928512 |