Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites
Objective: To assess the role of Th9 and Th17 cells in malignant ascites (MA). Methods: MA from 30 hepatic carcinoma patients and benign ascites from 30 cirrhotic patients were collected. Corresponding peripheral blood samples from these hepatic carcinoma and cirrhotic patients as well as 30 healthy...
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ftdoajarticles:oai:doaj.org/article:66629e1a19a5444e822bf706af7d70ad 2023-05-15T15:10:03+02:00 Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites Xian-Wen Yang Hai-Xing Jiang Xiao-Li Huang Shi-Jia Ma Shan-Yu Qin 2015-10-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.07.013 https://doaj.org/article/66629e1a19a5444e822bf706af7d70ad EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115001525 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.07.013 https://doaj.org/article/66629e1a19a5444e822bf706af7d70ad Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 10, Pp 806-811 (2015) Th9 cells Th17 cells Malignant ascites Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.07.013 2022-12-31T13:51:07Z Objective: To assess the role of Th9 and Th17 cells in malignant ascites (MA). Methods: MA from 30 hepatic carcinoma patients and benign ascites from 30 cirrhotic patients were collected. Corresponding peripheral blood samples from these hepatic carcinoma and cirrhotic patients as well as 30 healthy subjects were collected. The frequency of Th9 and Th17 cells was tested by flow cytometry. Serum levels of interleukin (IL)-9 and IL-17 were examined by ELISA. Results: The observed frequency of Th9 and Th17 cells, and the IL-9 and IL-17 serum levels were significantly higher in MA patients than those in cirrhotic patients and healthy control samples (P<0.05). Moreover, the Th9 cells demonstrated positive correlation with Th17 cells as well as IL-9 in MA patients; however, this positive correlation was not observed in the cirrhotic patients or healthy control samples. The frequency of Th9 and Th17 cells was distinctly higher in MA patients presenting with stage III or IV malignancy and with lymph node or distant metastasis than those in patients in stage I or II and without distant metastasis (P<0.05). Conclusions: The increased frequency of Th9 and Th17 cells in MA patients suggests that these two T cell subsets play a synergistic role in MA pathogenesis. This study also demonstrated that Th9 and Th17 cells may perform their biological functions in conjunction with IL-9 production. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 10 806 811 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Th9 cells Th17 cells Malignant ascites Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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Th9 cells Th17 cells Malignant ascites Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Xian-Wen Yang Hai-Xing Jiang Xiao-Li Huang Shi-Jia Ma Shan-Yu Qin Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites |
topic_facet |
Th9 cells Th17 cells Malignant ascites Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To assess the role of Th9 and Th17 cells in malignant ascites (MA). Methods: MA from 30 hepatic carcinoma patients and benign ascites from 30 cirrhotic patients were collected. Corresponding peripheral blood samples from these hepatic carcinoma and cirrhotic patients as well as 30 healthy subjects were collected. The frequency of Th9 and Th17 cells was tested by flow cytometry. Serum levels of interleukin (IL)-9 and IL-17 were examined by ELISA. Results: The observed frequency of Th9 and Th17 cells, and the IL-9 and IL-17 serum levels were significantly higher in MA patients than those in cirrhotic patients and healthy control samples (P<0.05). Moreover, the Th9 cells demonstrated positive correlation with Th17 cells as well as IL-9 in MA patients; however, this positive correlation was not observed in the cirrhotic patients or healthy control samples. The frequency of Th9 and Th17 cells was distinctly higher in MA patients presenting with stage III or IV malignancy and with lymph node or distant metastasis than those in patients in stage I or II and without distant metastasis (P<0.05). Conclusions: The increased frequency of Th9 and Th17 cells in MA patients suggests that these two T cell subsets play a synergistic role in MA pathogenesis. This study also demonstrated that Th9 and Th17 cells may perform their biological functions in conjunction with IL-9 production. |
format |
Article in Journal/Newspaper |
author |
Xian-Wen Yang Hai-Xing Jiang Xiao-Li Huang Shi-Jia Ma Shan-Yu Qin |
author_facet |
Xian-Wen Yang Hai-Xing Jiang Xiao-Li Huang Shi-Jia Ma Shan-Yu Qin |
author_sort |
Xian-Wen Yang |
title |
Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites |
title_short |
Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites |
title_full |
Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites |
title_fullStr |
Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites |
title_full_unstemmed |
Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites |
title_sort |
role of th9 cells and th17 cells in the pathogenesis of malignant ascites |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/j.apjtb.2015.07.013 https://doaj.org/article/66629e1a19a5444e822bf706af7d70ad |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 10, Pp 806-811 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115001525 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.07.013 https://doaj.org/article/66629e1a19a5444e822bf706af7d70ad |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.07.013 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
10 |
container_start_page |
806 |
op_container_end_page |
811 |
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