Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon
Abstract Background Schistosomiasis remains a parasitic infection of public health importance especially in Africa south of the Sahara including Cameroon. Chemotherapy using praziquantel has been the most effective and widespread control measure used. However, there are reports of reduced efficacy o...
Published in: | Tropical Medicine and Health |
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Format: | Article in Journal/Newspaper |
Language: | English |
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BMC
2017
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Online Access: | https://doi.org/10.1186/s41182-017-0071-8 https://doaj.org/article/6621548669ef43589b892230d441c2a5 |
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author | Calvin Bisong Ebai Helen Kuokuo Kimbi Irene Ule Ngole Sumbele Jude Ebah Yunga Leopold Gustave Lehman |
author_facet | Calvin Bisong Ebai Helen Kuokuo Kimbi Irene Ule Ngole Sumbele Jude Ebah Yunga Leopold Gustave Lehman |
author_sort | Calvin Bisong Ebai |
collection | Directory of Open Access Journals: DOAJ Articles |
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container_title | Tropical Medicine and Health |
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description | Abstract Background Schistosomiasis remains a parasitic infection of public health importance especially in Africa south of the Sahara including Cameroon. Chemotherapy using praziquantel has been the most effective and widespread control measure used. However, there are reports of reduced efficacy of the drug. The aim of this study was to assess the efficacy and safety of praziquantel against Schistosoma haematobium among infected individuals in the Ikata-Likoko area of southwest Cameroon. Following a baseline study, S. haematobium egg load was determined using the urine filtration technique and microscopy. Participants were treated with a unique dose of praziquantel of 40 mg/Kg body weight. A control test was carried out on the 42nd day post-treatment to determine the proportion of positive participants with viable eggs (cure rate) and the egg loads. The egg loads obtained during the control and at baseline were used to calculate the egg reduction rate (ERR) used as the main indicator of praziquantel efficacy according to the WHO, 2013 protocol. Results At baseline, the prevalence of S. haematobium was 34.3% (177/516). Out of these a total of 174 participants aged between 4 and 76 years were recruited into the study. A total of 130 participants came for follow up on day 42. Among them, 22.3% (29) were positive for eggs of S. haematobium but none of the eggs were viable giving a cure rate of 100%. The overall mean egg load per 10 mL (MEL/10 mL) of urine reduced from 31 (1–400) at baseline to 6.0 (1–35) on day 42. The overall ERR was reduced (80.3%). However, the efficacy was satisfactory (ERR ≥ 90%) in females, children ˂ 5 years, and some localities and for individuals with heavy infection intensity. Fifteen (8.6%) of the participants presented minor adverse events including abdominal disorders, headache and vomiting but did not last for more than 24 h. Conclusions Treatment with praziquantel was efficacious and safe showing reduction in prevalence as well as mean egg load in some individuals with few adverse ... |
format | Article in Journal/Newspaper |
genre | Arctic |
genre_facet | Arctic |
geographic | Arctic |
geographic_facet | Arctic |
id | ftdoajarticles:oai:doaj.org/article:6621548669ef43589b892230d441c2a5 |
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language | English |
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op_doi | https://doi.org/10.1186/s41182-017-0071-8 |
op_relation | http://link.springer.com/article/10.1186/s41182-017-0071-8 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-017-0071-8 1349-4147 https://doaj.org/article/6621548669ef43589b892230d441c2a5 |
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spelling | ftdoajarticles:oai:doaj.org/article:6621548669ef43589b892230d441c2a5 2025-01-16T20:49:49+00:00 Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon Calvin Bisong Ebai Helen Kuokuo Kimbi Irene Ule Ngole Sumbele Jude Ebah Yunga Leopold Gustave Lehman 2017-12-01T00:00:00Z https://doi.org/10.1186/s41182-017-0071-8 https://doaj.org/article/6621548669ef43589b892230d441c2a5 EN eng BMC http://link.springer.com/article/10.1186/s41182-017-0071-8 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-017-0071-8 1349-4147 https://doaj.org/article/6621548669ef43589b892230d441c2a5 Tropical Medicine and Health, Vol 45, Iss 1, Pp 1-8 (2017) Cameroon Efficacy Egg reduction rate Praziquantel Safety Schistosoma haematobium Arctic medicine. Tropical medicine RC955-962 article 2017 ftdoajarticles https://doi.org/10.1186/s41182-017-0071-8 2022-12-31T06:21:11Z Abstract Background Schistosomiasis remains a parasitic infection of public health importance especially in Africa south of the Sahara including Cameroon. Chemotherapy using praziquantel has been the most effective and widespread control measure used. However, there are reports of reduced efficacy of the drug. The aim of this study was to assess the efficacy and safety of praziquantel against Schistosoma haematobium among infected individuals in the Ikata-Likoko area of southwest Cameroon. Following a baseline study, S. haematobium egg load was determined using the urine filtration technique and microscopy. Participants were treated with a unique dose of praziquantel of 40 mg/Kg body weight. A control test was carried out on the 42nd day post-treatment to determine the proportion of positive participants with viable eggs (cure rate) and the egg loads. The egg loads obtained during the control and at baseline were used to calculate the egg reduction rate (ERR) used as the main indicator of praziquantel efficacy according to the WHO, 2013 protocol. Results At baseline, the prevalence of S. haematobium was 34.3% (177/516). Out of these a total of 174 participants aged between 4 and 76 years were recruited into the study. A total of 130 participants came for follow up on day 42. Among them, 22.3% (29) were positive for eggs of S. haematobium but none of the eggs were viable giving a cure rate of 100%. The overall mean egg load per 10 mL (MEL/10 mL) of urine reduced from 31 (1–400) at baseline to 6.0 (1–35) on day 42. The overall ERR was reduced (80.3%). However, the efficacy was satisfactory (ERR ≥ 90%) in females, children ˂ 5 years, and some localities and for individuals with heavy infection intensity. Fifteen (8.6%) of the participants presented minor adverse events including abdominal disorders, headache and vomiting but did not last for more than 24 h. Conclusions Treatment with praziquantel was efficacious and safe showing reduction in prevalence as well as mean egg load in some individuals with few adverse ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 45 1 |
spellingShingle | Cameroon Efficacy Egg reduction rate Praziquantel Safety Schistosoma haematobium Arctic medicine. Tropical medicine RC955-962 Calvin Bisong Ebai Helen Kuokuo Kimbi Irene Ule Ngole Sumbele Jude Ebah Yunga Leopold Gustave Lehman Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon |
title | Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon |
title_full | Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon |
title_fullStr | Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon |
title_full_unstemmed | Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon |
title_short | Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon |
title_sort | efficacy and safety of praziquantel against schistosoma haematobium in the ikata-likoko area of southwest cameroon |
topic | Cameroon Efficacy Egg reduction rate Praziquantel Safety Schistosoma haematobium Arctic medicine. Tropical medicine RC955-962 |
topic_facet | Cameroon Efficacy Egg reduction rate Praziquantel Safety Schistosoma haematobium Arctic medicine. Tropical medicine RC955-962 |
url | https://doi.org/10.1186/s41182-017-0071-8 https://doaj.org/article/6621548669ef43589b892230d441c2a5 |